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Kleine-Levin syndrome v1.7 CRY1 Eleanor Williams Classified gene: CRY1 as Red List (low evidence)
Kleine-Levin syndrome v1.7 CRY1 Eleanor Williams Added comment: Comment on list classification: Adding this gene as red to the panel after consultation with the Genomics England clinical team. There are sufficient cases to rate higher, but the phenotype, although sleep related, is not relevant to the panel scope which targets hypersomnolence, so keeping red for now.
Kleine-Levin syndrome v1.7 CRY1 Eleanor Williams Gene: cry1 has been classified as Red List (Low Evidence).
Kleine-Levin syndrome v1.6 CRY1 Eleanor Williams gene: CRY1 was added
gene: CRY1 was added to Kleine-Levin syndrome. Sources: Literature
Mode of inheritance for gene: CRY1 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Publications for gene: CRY1 were set to 32538895; 28388406
Phenotypes for gene: CRY1 were set to Attention deficit/hyperactivity disorder (ADHD); Delayed sleep phase disorder (DSPD)
Review for gene: CRY1 was set to RED
Added comment: Reviewed by Ee Ming Wong (Victorian Clinical Genetics Services) in PanelApp Australia https://panelapp.agha.umccr.org/panels/137/gene/CRY1/.

PMID: 32538895 - Onat et al 2020- heterozygous variants in 15 families with ADHD/insomnia. 
PMID: 28388406 - Patke et al 2017 - identify the CRY1 Δ11 GOF allele in an initial family and then additional families with Delayed Sleep Phase Disorder.
Sources: Literature
Kleine-Levin syndrome v1.5 DNMT1 Eleanor Williams Publications for gene: DNMT1 were set to 22328086; 24709307; 23904686
Kleine-Levin syndrome v1.4 DNMT1 Eleanor Williams reviewed gene: DNMT1: Rating: ; Mode of pathogenicity: None; Publications: 31984424; Phenotypes: ; Mode of inheritance: None
Kleine-Levin syndrome Sarah Leigh promoted panel to version 1
Kleine-Levin syndrome TRPV4 Sarah Leigh marked TRPV4 as ready
Kleine-Levin syndrome TRPV4 Sarah Leigh commented on TRPV4
Kleine-Levin syndrome TRPV4 Rosa Peraita-Adrados edited their review of TRPV4
Kleine-Levin syndrome TRPV4 Rosa Peraita-Adrados edited their review of TRPV4
Kleine-Levin syndrome HLA-DQB1 Sarah Leigh commented on HLA-DQB1
Kleine-Levin syndrome HLA-DQB1 Sarah Leigh added HLA-DQB1 to panel
Kleine-Levin syndrome HLA-DQB1 Sarah Leigh reviewed HLA-DQB1
Kleine-Levin syndrome TRPV4 Sarah Leigh classified TRPV4 as red
Kleine-Levin syndrome EXT1 Sarah Leigh marked EXT1 as ready
Kleine-Levin syndrome EXT1 Sarah Leigh classified EXT1 as red
Kleine-Levin syndrome EXT1 Sarah Leigh commented on EXT1
Kleine-Levin syndrome EXT1 Sarah Leigh classified EXT1 as amber
Kleine-Levin syndrome SLC6A4 Sarah Leigh marked SLC6A4 as ready
Kleine-Levin syndrome SLC6A4 Sarah Leigh commented on SLC6A4
Kleine-Levin syndrome PER2 Sarah Leigh marked PER2 as ready
Kleine-Levin syndrome PER2 Sarah Leigh commented on PER2
Kleine-Levin syndrome NTRK2 Sarah Leigh marked NTRK2 as ready
Kleine-Levin syndrome NTRK2 Sarah Leigh commented on NTRK2
Kleine-Levin syndrome MOG Sarah Leigh marked MOG as ready
Kleine-Levin syndrome MOG Sarah Leigh classified MOG as amber
Kleine-Levin syndrome MOG Sarah Leigh commented on MOG
Kleine-Levin syndrome MOG Sarah Leigh classified MOG as amber
Kleine-Levin syndrome HCRT Sarah Leigh marked HCRT as ready
Kleine-Levin syndrome HCRT Sarah Leigh commented on HCRT
Kleine-Levin syndrome CSNK1D Sarah Leigh marked CSNK1D as ready
Kleine-Levin syndrome CSNK1D Sarah Leigh commented on CSNK1D
Kleine-Levin syndrome CSNK1D Sarah Leigh classified CSNK1D as amber
Kleine-Levin syndrome AKR1C2 Sarah Leigh marked AKR1C2 as ready
Kleine-Levin syndrome AKR1C2 Sarah Leigh commented on AKR1C2
Kleine-Levin syndrome DNMT1 Sarah Leigh marked DNMT1 as ready
Kleine-Levin syndrome DNMT1 Sarah Leigh commented on DNMT1
Kleine-Levin syndrome EIF3G Sarah Leigh added EIF3G to panel
Kleine-Levin syndrome EIF3G Sarah Leigh reviewed EIF3G
Kleine-Levin syndrome EXT1 Rosa Peraita-Adrados commented on EXT1
Kleine-Levin syndrome EXT1 Rosa Peraita-Adrados added EXT1 to panel
Kleine-Levin syndrome EXT1 Rosa Peraita-Adrados reviewed EXT1
Kleine-Levin syndrome TRPV4 Rosa Peraita-Adrados edited their review of TRPV4
Kleine-Levin syndrome TRPV4 Rosa Peraita-Adrados added TRPV4 to panel
Kleine-Levin syndrome TRPV4 Rosa Peraita-Adrados reviewed TRPV4
Kleine-Levin syndrome MOG Rosa Peraita-Adrados reviewed MOG