ITGB2

Green ITGB2 in Infantile enterocolitis & monogenic inflammatory bowel disease

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.44

Sources

• UKGTN
• Radboud University Medical Center, Nijmegen
• Illumina TruGenome Clinical Sequencing Services
• Expert list

Phenotypes

• Leukocyte adhesion deficiency 116920

Amber ITGB2 in Gastrointestinal epithelial barrier disorders

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.75

Sources

• Expert Review Amber
• Expert list

Green ITGB2 in COVID-19 research

Level 2: Viral research
Version 1.142

Sources

• IUIS Classification February 2018
• London North GLH
• GOSH PID v.8.0
• NHS GMS
• GRID V2.0
• Victorian Clinical Genetics Services
• North West GLH
• ESID Registry 20171117
• Expert Review Green
• NHS GMS
• North West GLH
• London North GLH
• Expert Review Green
• IUIS Classification February 2018
• Victorian Clinical Genetics Services
• ESID Registry 20171117
• GRID V2.0
• GOSH PID v.8.0

Phenotypes

• Delayed cord separation, skin ulcers, periodontitis, leukocytosis
• Leukocyte adhesion deficiency type I
• Congenital defects of phagocyte number or function
• LAD
• Leukocyte adhesion deficiency, 116920

Green ITGB2 in Primary immunodeficiency or monogenic inflammatory bowel disease

Version 5.3
Latest signed off version: v5.0 (1 May 2024)

Sources

• NHS GMS
• North West GLH
• London North GLH
• Expert Review Green
• IUIS Classification February 2018
• Victorian Clinical Genetics Services
• ESID Registry 20171117
• GRID V2.0
• GOSH PID v.8.0

Phenotypes

• Leukocyte adhesion deficiency, 116920
• LAD
• Leukocyte adhesion deficiency type I
• Delayed cord separation, skin ulcers, periodontitis, leukocytosis
• Congenital defects of phagocyte number or function

Green ITGB2 in Severe Paediatric Disorders

Version 1.184

Sources

• Next Generation Children Project
• Expert Review Green
• Expert list

Phenotypes

• Leukocyte adhesion deficiency, 116920