TP53

tumor protein p53
OMIM: 191170, Gene2Phenotype

25 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 25 panels
Green TP53 in Familial breast cancer Level 3: Breast and endocrine Level 2: Tumour syndromes Version 1.20	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Expert list Emory Genetics Laboratory Radboud University Medical Center, Nijmegen Phenotypes Colorectal cancer, 114500 Li-Fraumeni syndrome, 151623 Hepatocellular carcinoma, 114550 Osteosarcoma, 259500 Choroid plexus papilloma, 260500 Nasopharyngeal carcinoma, 607107 Pancreatic cancer, 260350 Adrenal cortical carcinoma, 202300 Breast cancer, 114480 {Basal cell carcinoma 7}, 614740 {Glioma susceptibility 1}, 137800 High Risk Breast Cancer Breast and Ovarian Cancer
Green TP53 in Haematological malignancies for rare disease Level 3: Tumour syndromes Level 2: Tumour syndromes Version 1.18	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Curated sources Phenotypes Class: Familial cancer syndrome Li-Fraumeni syndrome ALL, AML, MDS Adrenal, breast, brain, and lung sarcoma, gastrointestinal cancers, Breast cancer, osteosarcoma, soft tissue sarcomas, brain tumors, adrenocortical carcinoma
Green TP53 in Brain cancer pertinent cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.4 Latest signed off version: v1.0 (29 Sep 2021)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Expert list Phenotypes Adult Glioma
Green TP53 in Breast cancer pertinent cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 2.12 Latest signed off version: v2.0 (22 Mar 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Expert list Phenotypes Breast cancer
Green TP53 in Familial Tumours Syndromes of the central & peripheral Nervous system Level 3: Muscle and nerve Level 2: Tumour syndromes Version 1.14	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Emory Genetics Laboratory Phenotypes Brain, CNS, and PNS Cancer
Green TP53 in Adult solid tumours for rare disease Level 3: Tumour syndromes Level 2: Tumour syndromes Version 1.40	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert list Expert Review Green Phenotypes Li Fraumeni Syndrome
Green TP53 in COVID-19 research Level 2: Viral research Version 1.142	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources OMIM IUIS Classification December 2019 Expert Review Green Phenotypes Bone marrow failure syndrome 5, 618165
Green TP53 in Familial rhabdomyosarcoma Level 3: Muscle and nerve Level 2: Tumour syndromes Version 1.5	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Eligibility statement prior genetic testing Expert list Phenotypes Li-Fraumeni syndrome, 151623
Red TP53 in Inherited ovarian cancer (without breast cancer) Level 3: Breast and endocrine Level 2: Tumour syndromes Version 4.3 Latest signed off version: v4.0 (22 Mar 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Red Radboud University Medical Center, Nijmegen Expert list Emory Genetics Laboratory Phenotypes Colorectal cancer, 114500 Li-Fraumeni syndrome, 151623 Hepatocellular carcinoma, 114550 Osteosarcoma, 259500 Choroid plexus papilloma, 260500 Nasopharyngeal carcinoma, 607107 Pancreatic cancer, 260350 Adrenal cortical carcinoma, 202300 Breast cancer, 114480 {Basal cell carcinoma 7}, 614740 {Glioma susceptibility 1}, 137800 High Risk Breast Cancer Breast and Ovarian Cancer
Red TP53 in GI tract tumours Level 3: GI tract Level 2: Tumour syndromes Version 1.22	review	Not set	Sources Emory Genetics Laboratory Phenotypes Gastrointestinal and Colorectal Cancer High Risk Colorectal Cancer
Green TP53 in Childhood solid tumours Level 3: Childhood Tumours Level 2: Tumour syndromes Version 4.18 Latest signed off version: v4.0 (22 Mar 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert List Expert Review Green Eligibility statement prior genetic testing Phenotypes Adrenocortical carcinoma Li Fraumeni Syndrome
Green TP53 in Multiple endocrine tumours Level 3: Breast and endocrine Level 2: Tumour syndromes Version 1.14	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Emory Genetics Laboratory Phenotypes Endocrine Cancer Paragangliomas 1, with or without deafness, 168000 Pheochromocytoma, 171300 Carcinoid tumors, intestinal, 114900 Merkel cell carcinoma, somatic Paraganglioma and gastric stromal sarcoma, 606864 Cowden syndrome 3, 615106
Red TP53 in Inherited phaeochromocytoma and paraganglioma Level 3: Breast and endocrine Level 2: Tumour syndromes Version 1.11	review	Not set	Sources Expert Review Red Emory Genetics Laboratory
Amber TP53 in Endocrine neoplasia Version 3.3 Latest signed off version: v3.0 (22 Mar 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Amber Expert Review Phenotypes Endocrine Cancer Paragangliomas 1, with or without deafness, 168000 Pheochromocytoma, 171300 Carcinoid tumors, intestinal, 114900 Merkel cell carcinoma, somatic Paraganglioma and gastric stromal sarcoma, 606864 Cowden syndrome 3, 615106
Green TP53 in Inherited predisposition to acute myeloid leukaemia (AML) Version 3.3 Latest signed off version: v3.0 (22 Mar 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green North West GLH Yorkshire and North East GLH NHS GMS Wessex and West Midlands GLH Phenotypes Li-Fraumeni syndrome, OMIM:151623 Li-Fraumeni syndrome 1, MONDO:0007903
Red TP53 in Cytopenias and congenital anaemias Level 3: Anaemias and red cell disorders Level 2: Haematological disorders Version 1.118	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Red BRIDGE consortium (NIHRBR-RD) Phenotypes Myelodysplastic syndrome (MDS), Paediatric
Green TP53 in Sarcoma cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.25	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Expert list Phenotypes Sarcoma
Green TP53 in Childhood solid tumours cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.27	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Expert list Phenotypes Li Fraumeni Syndrome
Green TP53 in Adult solid tumours cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 2.29 Latest signed off version: v2.2 (18 Feb 2020)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert Review Green Expert list Phenotypes Li Fraumeni Syndrome
Green TP53 in Haematological malignancies cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 4.5 Latest signed off version: v4.0 (22 Mar 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Curated sources Phenotypes Class: Familial cancer syndrome Li-Fraumeni syndrome ALL, AML, MDS Adrenal, breast, brain, and lung sarcoma, gastrointestinal cancers, Breast cancer, osteosarcoma, soft tissue sarcomas, brain tumors, adrenocortical carcinoma
Red TP53 in Skeletal dysplasia Level 3: Skeletal dysplasias Level 2: Skeletal disorders Version 5.3 Latest signed off version: v5.0 (1 May 2024) Component of the following Super Panels: Paediatric disorders	review	Other	Sources Expert Review Red Literature Phenotypes Central conventional chondrosrcoma Tags somatic
Red TP53 in Cytopenia - NOT Fanconi anaemia Version 3.34 Latest signed off version: v3.0 (22 Mar 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Red NHS GMS Yorkshire and North East GLH Phenotypes 618165 Bone marrow failure syndrome 5
Green TP53 in Sarcoma susceptibility Version 1.81 Latest signed off version: v1.2 (18 Feb 2020)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green NHS GMS Phenotypes Li-Fraumeni syndrome, OMIM:151623 Solitary Fibrous Tumour Sarcoma, MONDO:0005089
Green TP53 in Severe Paediatric Disorders Version 1.184	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Next Generation Children Project Expert Review Green Expert list Phenotypes Bone marrow failure syndrome 5, 618165 Li-Fraumeni syndrome, 151623
Green TP53 in Li Fraumeni Syndrome Version 1.3 Latest signed off version: v1.0 (22 Mar 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert Review Green

TP53

25 panels

Green TP53 in Familial breast cancer

Sources

Phenotypes

Green TP53 in Haematological malignancies for rare disease

Sources

Phenotypes

Green TP53 in Brain cancer pertinent cancer susceptibility

Sources

Phenotypes

Green TP53 in Breast cancer pertinent cancer susceptibility

Sources

Phenotypes

Green TP53 in Familial Tumours Syndromes of the central & peripheral Nervous system

Sources

Phenotypes

Green TP53 in Adult solid tumours for rare disease

Sources

Phenotypes

Green TP53 in COVID-19 research

Sources

Phenotypes

Green TP53 in Familial rhabdomyosarcoma

Sources

Phenotypes

Red TP53 in Inherited ovarian cancer (without breast cancer)

Sources

Phenotypes

Red TP53 in GI tract tumours

Sources

Phenotypes

Green TP53 in Childhood solid tumours

Sources

Phenotypes

Green TP53 in Multiple endocrine tumours

Sources

Phenotypes

Red TP53 in Inherited phaeochromocytoma and paraganglioma

Sources

Amber TP53 in Endocrine neoplasia

Sources

Phenotypes

Green TP53 in Inherited predisposition to acute myeloid leukaemia (AML)

Sources

Phenotypes

Red TP53 in Cytopenias and congenital anaemias

Sources

Phenotypes

Green TP53 in Sarcoma cancer susceptibility

Sources

Phenotypes

Green TP53 in Childhood solid tumours cancer susceptibility

Sources

Phenotypes

Green TP53 in Adult solid tumours cancer susceptibility

Sources

Phenotypes

Green TP53 in Haematological malignancies cancer susceptibility

Sources

Phenotypes

Red TP53 in Skeletal dysplasia

Sources

Phenotypes

Tags

Red TP53 in Cytopenia - NOT Fanconi anaemia

Sources

Phenotypes

Green TP53 in Sarcoma susceptibility

Sources

Phenotypes

Green TP53 in Severe Paediatric Disorders

Sources

Phenotypes

Green TP53 in Li Fraumeni Syndrome

Sources