1. Genes and Genomic Entities
  2. TRPM4

TRPM4

transient receptor potential cation channel subfamily M member 4
OMIM: 606936, Gene2Phenotype

4 panels

Panel Reviews Mode of inheritance Details
4 panels
Amber TRPM4 in Progressive cardiac conduction disease


Version 2.8
Latest signed off version: v2.7 (1 May 2024)

Component of the following Super Panels:

  • Sudden unexplained death or survivors of a cardiac event
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • South West GLH
    • London South GLH
    • Expert Review Amber
    • Wessex and West Midlands GLH
    Phenotypes
    • Progressive familial heart block, type IB, OMIM:604559
    Red TRPM4 in Short QT syndrome


    Version 3.12
    Latest signed off version: v3.11 (1 May 2024)

    Component of the following Super Panels:

  • Cardiac arrhythmias
  • Sudden unexplained death or survivors of a cardiac event
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • North West GLH
    • Brugada syndrome (Version 1.7)
    Phenotypes
    • Progressive familial heart block, type IB (604559)
    Red TRPM4 in Brugada syndrome and cardiac sodium channel disease

    Level 3: Cardiac arrhythmia
    Level 2: Cardiovascular disorders
    Version 3.10
    Latest signed off version: v3.9 (1 May 2024)

    Component of the following Super Panels:

  • Cardiac arrhythmias
  • Sudden unexplained death or survivors of a cardiac event
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • South West GLH
    • North West GLH
    • Oxford Medical Genetics Laboratory
    Phenotypes
    • Brugada syndrome, MONDO:0015263
    Green TRPM4 in Severe Paediatric Disorders


    Version 1.184

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Next Generation Children Project
    • Expert Review Green
    • Expert list
    Phenotypes
    • Erythrokeratodermia veriabilis et progressiva 6, 618531
    • Progressive familial heart block, type IB, 604559