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{
    "count": 170292,
    "next": "https://panelapp.genomicsengland.co.uk/api/v1/activities/?page=2",
    "previous": null,
    "results": [
        {
            "created": "2021-05-14T13:47:24.104693Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.43",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Classified gene: FANCM as Green List (high evidence)",
            "entity_name": "FANCM",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T13:47:24.101411Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.43",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: New gene added by Zornitza Stark (Australian Genomics). This gene is associated with a phenotype in OMIM and Gene2Phenotype. There is enough evidence for this gene to be rated Green.",
            "entity_name": "FANCM",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T13:47:24.072288Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.43",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Gene: fancm has been classified as Green List (High Evidence).",
            "entity_name": "FANCM",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T13:45:28.632003Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.42",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Phenotypes for gene: FANCM were changed from Premature ovarian failure to ?Premature ovarian failure 15, OMIM:618096",
            "entity_name": "FANCM",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T13:43:32.712488Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.41",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Tag watchlist tag was added to gene: EIF4ENIF1.",
            "entity_name": "EIF4ENIF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T13:43:22.565553Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.41",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Classified gene: EIF4ENIF1 as Amber List (moderate evidence)",
            "entity_name": "EIF4ENIF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T13:43:22.562250Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.41",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: Gene is not assiciated with a phenotype in OMIM or Gene2Phenotype. Gene will be kept as Amber until more evidence is available.",
            "entity_name": "EIF4ENIF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T13:43:22.536041Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.41",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Gene: eif4enif1 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "EIF4ENIF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T13:42:40.933172Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.40",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Deleted their review",
            "entity_name": "EIF4ENIF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T13:38:05.467104Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.40",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Added comment: Comment on publications: Added new publication.",
            "entity_name": "NANOS3",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T13:38:05.444084Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.40",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Publications for gene: NANOS3 were set to 24091668; 25054146; 28076512",
            "entity_name": "NANOS3",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T12:15:53.328815Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.39",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Publications for gene: NANOS3 were set to 24091668; 25054146",
            "entity_name": "NANOS3",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T12:07:37.519675Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.38",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Publications for gene: NANOS3 were set to 24091668",
            "entity_name": "NANOS3",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T12:06:06.028057Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.37",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Classified gene: MSH4 as Green List (high evidence)",
            "entity_name": "MSH4",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T12:06:06.020753Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.37",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Gene: msh4 has been classified as Green List (High Evidence).",
            "entity_name": "MSH4",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T12:05:50.538077Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.36",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "gene: MSH4 was added\ngene: MSH4 was added to Primary ovarian insufficiency. Sources: Literature\nMode of inheritance for gene: MSH4 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: MSH4 were set to 28541421; 10809667; 33437391; 33448284\nPhenotypes for gene: MSH4 were set to Primary ovarian insufficiency; primary ovarian failure, MONDO:0005387; non-obstructive azoospermia\nAdded comment: This gene is not associated with a phenotype in OMIM or Gene2Phenotype. \r\n\r\nPMID:28541421. 1 family affected by POI (NM_002440.3: c.2355+1G>A). Parents are heterozygous for the variant and 2 daughters (3 daughters and 2 sons in total) are homozygous for variant and diagnosed with POI. Variant causes exon skipping. \r\n\r\nPMID:10809667. Msh4 knockout mouse model. Mice were viable except for low testicular weight. -/- males were infertile. -/- females, most oocytes were lost from ovaries shortly after birth. \r\n\r\nPMID:33437391. Han Chinese patient with non-obstructive azoospermia (NOA) from a consanguineous family. Patient had homozygous variant in MSH4 (c.1552C>T:p.Q518X) and parents are heterozygous carriers.\r\n\r\nPMID:33448284. Consanguineous family with 14 children. 2 women have been diagnosed with POI, 3 men with NOA and 1 man with oligozoospermia. All affected individuals are homozygous for variant in MSH4 (S754L).\r\n\r\nThere is enough evidence to support a gene-disease association. This gene has been given a Green rating. \nSources: Literature",
            "entity_name": "MSH4",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T10:33:32.656092Z",
            "panel_name": "Clefting",
            "panel_id": 81,
            "panel_version": "2.30",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Publications for gene: TRAPPC9 were set to 20004764",
            "entity_name": "TRAPPC9",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T10:30:27.754451Z",
            "panel_name": "Intellectual disability",
            "panel_id": 285,
            "panel_version": "3.1080",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Publications for gene: TRAPPC9 were set to ",
            "entity_name": "TRAPPC9",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T10:30:00.154755Z",
            "panel_name": "Severe microcephaly",
            "panel_id": 162,
            "panel_version": "2.155",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Publications for gene: TRAPPC9 were set to 22549410; 20004765; 20004763; 30853973",
            "entity_name": "TRAPPC9",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T10:27:47.715709Z",
            "panel_name": "Severe microcephaly",
            "panel_id": 162,
            "panel_version": "2.154",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Tag Q2_21_rating tag was added to gene: TRAPPC9.",
            "entity_name": "TRAPPC9",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T10:27:39.651309Z",
            "panel_name": "Severe microcephaly",
            "panel_id": 162,
            "panel_version": "2.154",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Classified gene: TRAPPC9 as Amber List (moderate evidence)",
            "entity_name": "TRAPPC9",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T10:27:39.647954Z",
            "panel_name": "Severe microcephaly",
            "panel_id": 162,
            "panel_version": "2.154",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: There is sufficient evidence to promote this gene to Green at the next GMS panel update - at least 32 affected individuals from 9 families have been reported worldwide. Variable degrees of microcephaly are reported in almost all subjects and there are enough unrelated cases with sufficiently severe microcephaly to include as diagnostic-grade on this panel.",
            "entity_name": "TRAPPC9",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T10:27:39.621851Z",
            "panel_name": "Severe microcephaly",
            "panel_id": 162,
            "panel_version": "2.154",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Gene: trappc9 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "TRAPPC9",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T10:19:22.284529Z",
            "panel_name": "Neurodegenerative disorders - adult onset",
            "panel_id": 474,
            "panel_version": "2.174",
            "user_name": "Ian Berry",
            "item_type": "entity",
            "text": "reviewed gene: FIG4: Rating: RED; Mode of pathogenicity: None; Publications: PMID: 19118816; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
            "entity_name": "FIG4",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T09:42:51.809953Z",
            "panel_name": "Ectodermal dysplasia",
            "panel_id": 553,
            "panel_version": "1.19",
            "user_name": "Gavin Ryan",
            "item_type": "entity",
            "text": "reviewed gene: SNRPE: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
            "entity_name": "SNRPE",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T09:07:46.237118Z",
            "panel_name": "Severe microcephaly",
            "panel_id": 162,
            "panel_version": "2.153",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Phenotypes for gene: TRAPPC9 were changed from Mental retardation, autosomal recessive 13, MIM# 613192 to Mental retardation, autosomal recessive 13, OMIM:613192",
            "entity_name": "TRAPPC9",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T09:07:08.571225Z",
            "panel_name": "Intellectual disability",
            "panel_id": 285,
            "panel_version": "3.1079",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Phenotypes for gene: TRAPPC9 were changed from Mental retardation, autosomal recessive 13, 613192; Mental Retardation, Recessive; MENTAL RETARDATION AUTOSOMAL RECESSIVE TYPE 13 (MRT13) to Mental retardation, autosomal recessive 13, OMIM:613192",
            "entity_name": "TRAPPC9",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T09:06:29.250227Z",
            "panel_name": "Clefting",
            "panel_id": 81,
            "panel_version": "2.29",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Phenotypes for gene: TRAPPC9 were changed from MENTAL RETARDATION, AUTOSOMAL RECESSIVE 13;  MRT13 to Mental retardation, autosomal recessive 13, OMIM:613192",
            "entity_name": "TRAPPC9",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T09:03:30.351631Z",
            "panel_name": "Severe microcephaly",
            "panel_id": 162,
            "panel_version": "2.152",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Tag Q2_21_rating tag was added to gene: TRAPPC6B.",
            "entity_name": "TRAPPC6B",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T09:03:16.874407Z",
            "panel_name": "Severe microcephaly",
            "panel_id": 162,
            "panel_version": "2.152",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Phenotypes for gene: TRAPPC6B were changed from Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy, MIM# 617862 to Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy, OMIM:617862",
            "entity_name": "TRAPPC6B",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T09:03:15.998068Z",
            "panel_name": "Intellectual disability",
            "panel_id": 285,
            "panel_version": "3.1078",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Phenotypes for gene: TRAPPC6B were changed from Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy, 617862 to Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy, OMIM:617862",
            "entity_name": "TRAPPC6B",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T09:02:52.843422Z",
            "panel_name": "Genetic epilepsy syndromes",
            "panel_id": 402,
            "panel_version": "2.354",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Phenotypes for gene: TRAPPC6B were changed from Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy, 617862 to Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy, OMIM:617862",
            "entity_name": "TRAPPC6B",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T09:02:20.788822Z",
            "panel_name": "Genetic epilepsy syndromes",
            "panel_id": 402,
            "panel_version": "2.353",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Publications for gene: TRAPPC6B were set to 28626029; 28397838; DOI 10.1055/s-0039-1693664",
            "entity_name": "TRAPPC6B",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T09:02:19.509534Z",
            "panel_name": "Intellectual disability",
            "panel_id": 285,
            "panel_version": "3.1077",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Publications for gene: TRAPPC6B were set to 28626029; 28397838",
            "entity_name": "TRAPPC6B",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T09:01:44.654772Z",
            "panel_name": "Severe microcephaly",
            "panel_id": 162,
            "panel_version": "2.151",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Classified gene: TRAPPC6B as Amber List (moderate evidence)",
            "entity_name": "TRAPPC6B",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T09:01:44.652260Z",
            "panel_name": "Severe microcephaly",
            "panel_id": 162,
            "panel_version": "2.151",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: There is sufficient evidence to promote this gene to Green at the next GMS panel update - 9 individuals from 5 families have been reported, all harbouring loss-of-function variants in homozygous state. Progressive microcephaly of relevant severity to this panel (HC ≤ -3 SD) was reported in 7/7 cases (clinical details limited for one family). \r\n\r\nTRAPPC6B is associated with a relevant phenotype in OMIM (MIM# 617862)",
            "entity_name": "TRAPPC6B",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T09:01:44.630500Z",
            "panel_name": "Severe microcephaly",
            "panel_id": 162,
            "panel_version": "2.151",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Gene: trappc6b has been classified as Amber List (Moderate Evidence).",
            "entity_name": "TRAPPC6B",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T08:31:12.767321Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.35",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Tag watchlist tag was added to gene: MSH5.",
            "entity_name": "MSH5",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T08:30:57.343391Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.35",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Classified gene: MSH5 as Amber List (moderate evidence)",
            "entity_name": "MSH5",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T08:30:57.340199Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.35",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: Promoted from Red to Amber. This gene is associated with a phenotype in OMIM but not Gene2Phenotype. There is currently not enough evidence to support a gene-disease association. This gene has been given an Amber rating.",
            "entity_name": "MSH5",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T08:30:57.312334Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.35",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Gene: msh5 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "MSH5",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T08:21:28.120078Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.34",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Phenotypes for gene: MSH5 were changed from ?Premature ovarian failure 13 617442 to ?Premature ovarian failure 13, OMIM:617442",
            "entity_name": "MSH5",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T08:20:50.081503Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.33",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Publications for gene: MSH5 were set to 28175301",
            "entity_name": "MSH5",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T08:20:06.298951Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.32",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Classified gene: EIF4ENIF1 as Green List (high evidence)",
            "entity_name": "EIF4ENIF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T08:20:06.295637Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.32",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: Promoted from Amber to Green. This gene is not associated with a phenotype in OMIM or Gene2Phenotype. There is 3 unrelated cases associated with this gene, therefore there is enough evidence to support a gene-disease association.",
            "entity_name": "EIF4ENIF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-14T08:20:06.266825Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.32",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Gene: eif4enif1 has been classified as Green List (High Evidence).",
            "entity_name": "EIF4ENIF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T20:21:20.393582Z",
            "panel_name": "Clefting",
            "panel_id": 81,
            "panel_version": "2.28",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "reviewed gene: SEPT9: Rating: AMBER; Mode of pathogenicity: None; Publications: 18492087; Phenotypes: Amyotrophy, hereditary neuralgic, MIM# 162100; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
            "entity_name": "SEPT9",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:35:02.488735Z",
            "panel_name": "Childhood onset dystonia or chorea or related movement disorder",
            "panel_id": 847,
            "panel_version": "1.105",
            "user_name": "Sarah Leigh",
            "item_type": "entity",
            "text": "changed review comment from: The FXN expansion has a well recognized association with Friedreich ataxia OMIM:229300; to: The FXN expansion has a well recognized association with Friedreich ataxia OMIM:229300\r\n\r\nComment from Zornitza Stark for FXN:\r\nPrimarily an ataxia, and also commonly caused by a GAA trinucleotide repeat expansion in intron 1 of the FXN gene.",
            "entity_name": "FXN_GAA",
            "entity_type": "str"
        },
        {
            "created": "2021-05-13T14:23:30.732150Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.31",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Publications for gene: EIF4ENIF1 were set to 23902945",
            "entity_name": "EIF4ENIF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:22:05.071228Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.30",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Classified gene: DIAPH2 as Red List (low evidence)",
            "entity_name": "DIAPH2",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:22:05.067080Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.30",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: Demoted from Amber to Red based on expert review.",
            "entity_name": "DIAPH2",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:22:05.030797Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.30",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Gene: diaph2 has been classified as Red List (Low Evidence).",
            "entity_name": "DIAPH2",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:21:04.929237Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.29",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Phenotypes for gene: DIAPH2 were changed from Premature ovarian failure,300511 to ?Premature ovarian failure 2A, OMIM:300511",
            "entity_name": "DIAPH2",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:20:42.977548Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.28",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Publications for gene: DIAPH2 were set to 9497258",
            "entity_name": "DIAPH2",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:18:50.979884Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.27",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Classified gene: HSF2BP as Red List (low evidence)",
            "entity_name": "HSF2BP",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:18:50.976470Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.27",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: New gene added by Zornitza Stark (Australian Genomics). This gene is associated with a phenotype in OMIM but not in Gene2Phenotype. There is currently not enough evidence to support gene-disease association. This gene has been given a Red rating.",
            "entity_name": "HSF2BP",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:18:50.947659Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.27",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Gene: hsf2bp has been classified as Red List (Low Evidence).",
            "entity_name": "HSF2BP",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:17:36.184087Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.26",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Phenotypes for gene: HSF2BP were changed from Premature ovarian failure, OMIM#619245 to Premature ovarian failure 19, OMIM:619245",
            "entity_name": "HSF2BP",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:16:15.419458Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.25",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Classified gene: C14orf39 as Amber List (moderate evidence)",
            "entity_name": "C14orf39",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:16:15.416161Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.25",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: New gene added by Zornitza Stark (Australian Genomics). This gene is associated with a phenotype in OMIM but not in Gene2Phenotype. There is currently not enough evidence to support a gene-disease association. This gene has been given an Amber rating.",
            "entity_name": "C14orf39",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:16:15.390259Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.25",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Gene: c14orf39 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "C14orf39",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:15:02.613675Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.24",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Phenotypes for gene: C14orf39 were changed from Premature ovarian insufficiency to ?Premature ovarian failure 18, OMIM:619203",
            "entity_name": "C14orf39",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:13:26.315951Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.23",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Classified gene: BUB1B as Amber List (moderate evidence)",
            "entity_name": "BUB1B",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:13:26.313047Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.23",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: New gene added by Zornitza Stark (Australian Genomics). There is currently not enough evidence to support a gene-disease association. This gene has been given an Amber rating.",
            "entity_name": "BUB1B",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T14:13:26.291331Z",
            "panel_name": "Primary ovarian insufficiency",
            "panel_id": 155,
            "panel_version": "1.23",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Gene: bub1b has been classified as Amber List (Moderate Evidence).",
            "entity_name": "BUB1B",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T12:25:45.152219Z",
            "panel_name": "Thoracic aortic aneurysm or dissection",
            "panel_id": 1,
            "panel_version": "1.114",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Classified gene: PKD2 as Red List (low evidence)",
            "entity_name": "PKD2",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T12:25:45.148415Z",
            "panel_name": "Thoracic aortic aneurysm or dissection",
            "panel_id": 1,
            "panel_version": "1.114",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: Demoted from Amber to Red based on expert reviews. This gene is also Red on the Thoracic aortic aneurysm and dissection (Version 1.7) panel.",
            "entity_name": "PKD2",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T12:25:45.118627Z",
            "panel_name": "Thoracic aortic aneurysm or dissection",
            "panel_id": 1,
            "panel_version": "1.114",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Gene: pkd2 has been classified as Red List (Low Evidence).",
            "entity_name": "PKD2",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T12:25:08.699472Z",
            "panel_name": "Thoracic aortic aneurysm or dissection",
            "panel_id": 1,
            "panel_version": "1.113",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Classified gene: PKD1 as Red List (low evidence)",
            "entity_name": "PKD1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T12:25:08.696756Z",
            "panel_name": "Thoracic aortic aneurysm or dissection",
            "panel_id": 1,
            "panel_version": "1.113",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: Demoted from Amber to Red based on expert reviews. This gene is also Red on the Thoracic aortic aneurysm and dissection (Version 1.7) panel.",
            "entity_name": "PKD1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T12:25:08.675023Z",
            "panel_name": "Thoracic aortic aneurysm or dissection",
            "panel_id": 1,
            "panel_version": "1.113",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Gene: pkd1 has been classified as Red List (Low Evidence).",
            "entity_name": "PKD1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T12:16:11.675739Z",
            "panel_name": "White matter disorders and cerebral calcification - narrow panel",
            "panel_id": 476,
            "panel_version": "1.94",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Classified gene: ACER3 as Amber List (moderate evidence)",
            "entity_name": "ACER3",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T12:16:11.673150Z",
            "panel_name": "White matter disorders and cerebral calcification - narrow panel",
            "panel_id": 476,
            "panel_version": "1.94",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: New gene added by Zornitza Stark (Australian Genomics). This gene is associated with a relevant phenotype in OMIM but not in Gene2Phenotype. Currently, there is not enough evidence to support a gene-disease association. This gene has been given an Amber rating.",
            "entity_name": "ACER3",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T12:16:11.653754Z",
            "panel_name": "White matter disorders and cerebral calcification - narrow panel",
            "panel_id": 476,
            "panel_version": "1.94",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Gene: acer3 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "ACER3",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T12:15:07.543941Z",
            "panel_name": "White matter disorders and cerebral calcification - narrow panel",
            "panel_id": 476,
            "panel_version": "1.93",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Tag watchlist tag was added to gene: ACER3.",
            "entity_name": "ACER3",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T12:05:35.010961Z",
            "panel_name": "White matter disorders and cerebral calcification - narrow panel",
            "panel_id": 476,
            "panel_version": "1.93",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Phenotypes for gene: ACER3 were changed from Leukodystrophy to ?Leukodystrophy, progressive, early childhood-onset, OMIM:617762",
            "entity_name": "ACER3",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T11:51:24.254275Z",
            "panel_name": "Childhood onset dystonia or chorea or related movement disorder",
            "panel_id": 847,
            "panel_version": "1.105",
            "user_name": "Sarah Leigh",
            "item_type": "entity",
            "text": "Tag Q2_21_rating tag was added to STR: FXN_GAA.",
            "entity_name": "FXN_GAA",
            "entity_type": "str"
        },
        {
            "created": "2021-05-13T11:50:56.179482Z",
            "panel_name": "Childhood onset dystonia or chorea or related movement disorder",
            "panel_id": 847,
            "panel_version": "1.105",
            "user_name": "Sarah Leigh",
            "item_type": "entity",
            "text": "edited their review of STR: FXN_GAA: Added comment: The FXN expansion has a well recognized association with Friedreich ataxia OMIM:229300; Changed rating: GREEN; Changed publications to: 10399865, 8596916, 33670433",
            "entity_name": "FXN_GAA",
            "entity_type": "str"
        },
        {
            "created": "2021-05-13T11:22:17.752338Z",
            "panel_name": "Childhood onset dystonia or chorea or related movement disorder",
            "panel_id": 847,
            "panel_version": "1.105",
            "user_name": "Sarah Leigh",
            "item_type": "entity",
            "text": "Classified STR: FXN_GAA as Amber List (moderate evidence)",
            "entity_name": "FXN_GAA",
            "entity_type": "str"
        },
        {
            "created": "2021-05-13T11:22:17.749220Z",
            "panel_name": "Childhood onset dystonia or chorea or related movement disorder",
            "panel_id": 847,
            "panel_version": "1.105",
            "user_name": "Sarah Leigh",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: There is enough evidence for this gene to be rated GREEN at the next major review.",
            "entity_name": "FXN_GAA",
            "entity_type": "str"
        },
        {
            "created": "2021-05-13T11:22:17.723243Z",
            "panel_name": "Childhood onset dystonia or chorea or related movement disorder",
            "panel_id": 847,
            "panel_version": "1.105",
            "user_name": "Sarah Leigh",
            "item_type": "entity",
            "text": "Str: fxn_gaa has been classified as Amber List (Moderate Evidence).",
            "entity_name": "FXN_GAA",
            "entity_type": "str"
        },
        {
            "created": "2021-05-13T11:20:36.783984Z",
            "panel_name": "Childhood onset dystonia or chorea or related movement disorder",
            "panel_id": 847,
            "panel_version": "1.104",
            "user_name": "Sarah Leigh",
            "item_type": "entity",
            "text": "Entity copied from Ataxia and cerebellar anomalies - narrow panel v2.175",
            "entity_name": "FXN_GAA",
            "entity_type": "str"
        },
        {
            "created": "2021-05-13T11:20:36.699910Z",
            "panel_name": "Childhood onset dystonia or chorea or related movement disorder",
            "panel_id": 847,
            "panel_version": "1.104",
            "user_name": "Sarah Leigh",
            "item_type": "entity",
            "text": "STR: FXN_GAA was added\nSTR: FXN_GAA was added to Childhood onset dystonia or chorea or related movement disorder. Sources: Expert list,Expert Review Green\nSTR tags were added to STR: FXN_GAA.\nMode of inheritance for STR: FXN_GAA was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for STR: FXN_GAA were set to Friedreich ataxia OMIM:229300; Friedreich ataxia with retained reflexes OMIM:229300; Friedreich ataxia 1 MONDO:0100340",
            "entity_name": "FXN_GAA",
            "entity_type": "str"
        },
        {
            "created": "2021-05-13T10:48:52.594468Z",
            "panel_name": "Severe microcephaly",
            "panel_id": 162,
            "panel_version": "2.150",
            "user_name": "Eleanor Williams",
            "item_type": "entity",
            "text": "changed review comment from: Associated with Neurodevelopmental disorder and structural brain anomalies with or without seizures and spasticity\t#618890 in OMIM, \r\n\r\nSevere microcephaly confirmed in 2 cases, a further 3 cases with microcephaly reported. \r\n\r\nPMID:31395947 - Bend et al 2020 - 7 patients with biallelic variants in PTPN23. 2 have microcephaly noted (1 with occipito-frontal head circumference (OFC) −3SD along with severe growth restriction, in the other the degree is not noted).  In a 3rd case borderline microcephaly is reported (10th percentile).\r\n\r\nPMID:29899372 - Smigiel et al 2018 -  1 patient with severe developmental delay, epilepsy, cortical blindness, hypomyelination and brain atrophy and compound heterozygous PTPN23 variants (c.1902C>G;p.(Asn634Lys), c.2974delC;p.(Leu992Tyrfs*168) identified by WES.  OFC at birth was 30 cm (2 cm below 3 percentile), weight 2320 g (300 g below 3 percentile), length 52 cm (50–90 percentile), \r\n\r\nPMID: 29090338 - Sowada et al 2017-  1 patient with developmental and epileptic encephalopathy with compound heterozygous PTPN23 variants (c.3586C>T (p.Arg1196*) and c.1595C>T (p.Pro532Leu)). OFC at birth was 31 cm (− 2.6 SD) but weight was 50th and length 26th percentile. \r\n\r\nPMID: 27848944 - Trujillano et al 2017 - 1 patient with homozygous c.904A>G\tp.(M302V) variant in PTPN23 and microcephaly reported as part of the clinical phenotype. No details as to severity of the microcephaly. They classify the variant as a VUS. \r\n\r\nPMID: 25558065 - Alazami et al 2015 - 1 patient with a variant  (NM_015466:c.3995G >\r\nT:p.R1332L) in PTPN23 and Global developmental delay, epilepsy and brain atrophy.  Microcephaly not mentioned in publication, however in Bend et al 2020 Table 1 says this patient has progressive microcephaly.; to: Associated with Neurodevelopmental disorder and structural brain anomalies with or without seizures and spasticity\t#618890 in OMIM, \r\n\r\nSevere microcephaly (OFC > 3 SD below mean) confirmed in 1 case, a further 4 cases with microcephaly reported. \r\n\r\nPMID:31395947 - Bend et al 2020 - 7 patients with biallelic variants in PTPN23. 2 have microcephaly noted (1 with occipito-frontal head circumference (OFC) −3SD along with severe growth restriction, in the other the degree is not noted).  In a 3rd case borderline microcephaly is reported (10th percentile).\r\n\r\nPMID:29899372 - Smigiel et al 2018 -  1 patient with severe developmental delay, epilepsy, cortical blindness, hypomyelination and brain atrophy and compound heterozygous PTPN23 variants (c.1902C>G;p.(Asn634Lys), c.2974delC;p.(Leu992Tyrfs*168) identified by WES.  OFC at birth was 30 cm (2 cm below 3 percentile), weight 2320 g (300 g below 3 percentile), length 52 cm (50–90 percentile), \r\n\r\nPMID: 29090338 - Sowada et al 2017-  1 patient with developmental and epileptic encephalopathy with compound heterozygous PTPN23 variants (c.3586C>T (p.Arg1196*) and c.1595C>T (p.Pro532Leu)). OFC at birth was 31 cm (− 2.6 SD) but weight was 50th and length 26th percentile. \r\n\r\nPMID: 27848944 - Trujillano et al 2017 - 1 patient with homozygous c.904A>G\tp.(M302V) variant in PTPN23 and microcephaly reported as part of the clinical phenotype. No details as to severity of the microcephaly. They classify the variant as a VUS. \r\n\r\nPMID: 25558065 - Alazami et al 2015 - 1 patient with a variant  (NM_015466:c.3995G >\r\nT:p.R1332L) in PTPN23 and Global developmental delay, epilepsy and brain atrophy.  Microcephaly not mentioned in publication, however in Bend et al 2020 Table 1 says this patient has progressive microcephaly.",
            "entity_name": "PTPN23",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T10:38:56.115749Z",
            "panel_name": "Severe microcephaly",
            "panel_id": 162,
            "panel_version": "2.150",
            "user_name": "Eleanor Williams",
            "item_type": "entity",
            "text": "reviewed gene: PTPN23: Rating: AMBER; Mode of pathogenicity: None; Publications: 31395947, 29899372, 29090338, 27848944, 25558065; Phenotypes: Neurodevelopmental disorder and structural brain anomalies with or without seizures and spasticity, OMIM:618890; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
            "entity_name": "PTPN23",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T10:27:34.199148Z",
            "panel_name": "Ataxia and cerebellar anomalies - narrow panel",
            "panel_id": 477,
            "panel_version": "2.175",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Classified gene: MTCL1 as Amber List (moderate evidence)",
            "entity_name": "MTCL1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T10:27:34.196425Z",
            "panel_name": "Ataxia and cerebellar anomalies - narrow panel",
            "panel_id": 477,
            "panel_version": "2.175",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: New gene added by Zornitza Stark. There is sufficient evidence to promote this gene to Green at the next GMS panel update - two unrelated individuals with different LoF variants in this gene. Ataxia with cerebellar atrophy was the predominant presentation in both cases (PMIDs:\t30548255; 32961396). Knockout animal model recapitulates human phenotypes and provides functional support.",
            "entity_name": "MTCL1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T10:27:34.182113Z",
            "panel_name": "Ataxia and cerebellar anomalies - narrow panel",
            "panel_id": 477,
            "panel_version": "2.175",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Gene: mtcl1 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "MTCL1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T10:22:59.360118Z",
            "panel_name": "Ataxia and cerebellar anomalies - narrow panel",
            "panel_id": 477,
            "panel_version": "2.174",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "Tag Q2_21_rating tag was added to gene: MTCL1.",
            "entity_name": "MTCL1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T10:21:50.765815Z",
            "panel_name": "Ataxia and cerebellar anomalies - narrow panel",
            "panel_id": 477,
            "panel_version": "2.174",
            "user_name": "Arina Puzriakova",
            "item_type": "entity",
            "text": "reviewed gene: MTCL1: Rating: GREEN; Mode of pathogenicity: None; Publications: 30548255, 32961396; Phenotypes: Cerebellar ataxia; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
            "entity_name": "MTCL1",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T09:57:16.694427Z",
            "panel_name": "Ehlers Danlos syndromes",
            "panel_id": 53,
            "panel_version": "2.57",
            "user_name": "Andžela Lazdāne",
            "item_type": "entity",
            "text": "changed review comment from: Based on the literature several individuals were suspected of marfan syndrome. Not only due to eye changes, but also due to stature, increased arm span and decreased upper-to-lower body ratio. \nSources: Literature; to: Based on the literature several individuals were suspected of Marfan syndrome. Not only due to eye changes, but also due to stature, increased arm span and decreased upper-to-lower body ratio. \r\nSources: Literature",
            "entity_name": "LTBP2",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T09:55:57.504637Z",
            "panel_name": "Ehlers Danlos syndromes",
            "panel_id": 53,
            "panel_version": "2.57",
            "user_name": "Andžela Lazdāne",
            "item_type": "entity",
            "text": "gene: LTBP2 was added\ngene: LTBP2 was added to Ehlers Danlos syndromes. Sources: Literature\nMode of inheritance for gene: LTBP2 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: LTBP2 were set to PMID: 20179738; PMID: 20617341\nPhenotypes for gene: LTBP2 were set to Inreased arm-span-to-height ratio; Decreased upper-to-lower body ratio; Lens dislocation; Pectus excavatum; Myopia\nPenetrance for gene: LTBP2 were set to Complete\nReview for gene: LTBP2 was set to AMBER\nAdded comment: Based on the literature several individuals were suspected of marfan syndrome. Not only due to eye changes, but also due to stature, increased arm span and decreased upper-to-lower body ratio. \nSources: Literature",
            "entity_name": "LTBP2",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T09:17:53.049217Z",
            "panel_name": "White matter disorders and cerebral calcification - narrow panel",
            "panel_id": 476,
            "panel_version": "1.92",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Publications for gene: KIAA1161 were set to 30656188; 30649222; 30460687; 29910000; 31951047; 33958240, 30649222",
            "entity_name": "KIAA1161",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T09:17:14.677164Z",
            "panel_name": "White matter disorders and cerebral calcification - narrow panel",
            "panel_id": 476,
            "panel_version": "1.91",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Publications for gene: KIAA1161 were set to 30656188; 30649222; 30460687; 29910000; 31951047",
            "entity_name": "KIAA1161",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T08:56:20.296064Z",
            "panel_name": "White matter disorders and cerebral calcification - narrow panel",
            "panel_id": 476,
            "panel_version": "1.90",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Classified gene: ZFYVE26 as Amber List (moderate evidence)",
            "entity_name": "ZFYVE26",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T08:56:20.292765Z",
            "panel_name": "White matter disorders and cerebral calcification - narrow panel",
            "panel_id": 476,
            "panel_version": "1.90",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Added comment: Comment on list classification: Promoted Red to Amber. This gene is associated with a relevant phenotype in OMIM and Gene2Phenotype. This gene is Green on the  White matter disorders - adult onset (Version 1.10) panel. The age of onset can be in childhood. This gene should be Green at the next review.",
            "entity_name": "ZFYVE26",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T08:56:20.267053Z",
            "panel_name": "White matter disorders and cerebral calcification - narrow panel",
            "panel_id": 476,
            "panel_version": "1.90",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Gene: zfyve26 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "ZFYVE26",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-13T08:51:13.070963Z",
            "panel_name": "White matter disorders and cerebral calcification - narrow panel",
            "panel_id": 476,
            "panel_version": "1.89",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Tag Q2_21_rating tag was added to gene: ZFYVE26.",
            "entity_name": "ZFYVE26",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-12T14:13:12.583380Z",
            "panel_name": "White matter disorders and cerebral calcification - narrow panel",
            "panel_id": 476,
            "panel_version": "1.89",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "Phenotypes for gene: KIAA1161 were changed from  to Basal ganglia calcification, idiopathic, 7, autosomal recessive, OMIM:618317",
            "entity_name": "KIAA1161",
            "entity_type": "gene"
        },
        {
            "created": "2021-05-12T14:11:47.901468Z",
            "panel_name": "White matter disorders and cerebral calcification - narrow panel",
            "panel_id": 476,
            "panel_version": "1.88",
            "user_name": "Ivone Leong",
            "item_type": "entity",
            "text": "commented on gene: KIAA1161",
            "entity_name": "KIAA1161",
            "entity_type": "gene"
        }
    ]
}