Entity Name	Entity type	Gene Symbol	Sources(; separated)	Level4	Level3	Level2	Model_Of_Inheritance	Phenotypes	Omim	Orphanet	HPO	Publications	Description	Flagged	GEL_Status	UserRatings_Green_amber_red	version	ready	Mode of pathogenicity	EnsemblId(GRch37)	EnsemblId(GRch38)	HGNC	Position Chromosome	Position GRCh37 Start	Position GRCh37 End	Position GRCh38 Start	Position GRCh38 End	STR Repeated Sequence	STR Normal Repeats	STR Pathogenic Repeats	Region Haploinsufficiency Score	Region Triplosensitivity Score	Region Required Overlap Percentage	Region Variant Type	Region Verbose Name
ACTN4	gene	ACTN4	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Glomerulosclerosis, focal segmental, 1 603278				10700177;26301083;16251236;29043128		False	3	100;0;0	5.10	True	Other - please provide details in the comments	ENSG00000130402	ENSG00000130402	HGNC:166													
AMN	gene	AMN	Expert;Expert Review Green;NHS GMS;Radboud University Medical Center, Nijmegen	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Megaloblastic anemia-1, Norwegian type, OMIM:261100				12590260;26040326		False	3	33;33;33	5.10	True		ENSG00000166126	ENSG00000166126	HGNC:14604													
APOE	gene	APOE	Expert Review Green;Literature	Proteinuric renal disease		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Lipoprotein glomerulopathy, OMIM:611771				10432380;9176854;18077821;31092271		False	3	100;0;0	5.10	False		ENSG00000130203	ENSG00000130203	HGNC:613													
ARHGDIA	gene	ARHGDIA	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Nephrotic syndrome, type 8 #615224				23434736;23867502;30295827		False	3	0;100;0	5.10	True		ENSG00000141522	ENSG00000141522	HGNC:678													
CD151	gene	CD151	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Nephropathy with pretibial epidermolysis bullosa and deafness, OMIM:609057;nephrotic syndrome - deafness - pretibial epidermolysis bullosa syndrome, MONDO:0012190				15265795;17015618;29138120;32641585;22338088;18787104;22201679		False	3	50;25;25	5.10	True		ENSG00000177697	ENSG00000177697	HGNC:1630													
CD2AP	gene	CD2AP	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Glomerulosclerosis, focal segmental, 3, OMIM:607832;focal segmental glomerulosclerosis 3, susceptibility to, MONDO:0011917				10514378;12764198;17713465;19131354;25501161;26997877;30348286;30612599;34408996;36964972		False	3	25;75;0	5.10	True		ENSG00000198087	ENSG00000198087	HGNC:14258													
CLCN5	gene	CLCN5	Expert Review Green;NHS GMS;Radboud University Medical Center, Nijmegen	Proteinuric renal disease		Renal	X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)	Dent disease, 300009; Nephrolithiasis, type I, 310468; Hypophosphatemic rickets, 300554; Proteinuria, low molecular weight, with hypercalciuric nephrocalcinosis, 308990				27757584;25907713;23886564		False	3	50;50;0	5.10	True		ENSG00000171365	ENSG00000171365	HGNC:2023													
COL4A3	gene	COL4A3	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Alport syndrome, autosomal dominant #104200;Alport syndrome, autosomal recessive #203780;Hematuria, benign familial #141200				30506145;29987460;24052634		False	3	100;0;0	5.10	True		ENSG00000169031	ENSG00000169031	HGNC:2204													
COL4A4	gene	COL4A4	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Alport syndrome 2, autosomal recessive, OMIM:203780;Hematuria,familial benign, OMIM:141200				30506145;29987460;24052634		False	3	100;0;0	5.10	True		ENSG00000081052	ENSG00000081052	HGNC:2206													
COL4A5	gene	COL4A5	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)	Alports;Familial benign haematuria;Alport syndrome;proteinuria;haematuria;FSGS				29987460;29270492		False	3	100;0;0	5.10	True		ENSG00000188153	ENSG00000188153	HGNC:2207													
COQ2	gene	COQ2	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Coenzyme Q10 deficiency, primary, 1, OMIM:607426				17855635;29637272;30180404		False	3	100;0;0	5.10	True		ENSG00000173085	ENSG00000173085	HGNC:25223													
COQ6	gene	COQ6	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Coenzyme Q10 deficiency, primary, 6 #614650				21540551		False	3	50;50;0	5.10	True		ENSG00000119723	ENSG00000119723	HGNC:20233													
COQ8B	gene	COQ8B	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Nephrotic syndrome, type 9 #615573				24270420		False	3	100;0;0	5.10	False		ENSG00000123815	ENSG00000123815	HGNC:19041													
CRB2	gene	CRB2	Expert Review Green;Literature;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	steroid resistant nephrotic syndrome;Focal segmental glomerulosclerosis 9 #616220;Ventriculomegaly with cystic kidney disease #219730				25557779;27942854;29473663		False	3	100;0;0	5.10	False		ENSG00000148204	ENSG00000148204	HGNC:18688													
CUBN	gene	CUBN	Expert;Expert Review Green;Illumina TruGenome Clinical Sequencing Services;NHS GMS;Radboud University Medical Center, Nijmegen	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Megaloblastic anemia-1, Finnish type, 261100;Megaloblastic Anemia; (originally on the Imerslund-Grasbeck syndrome gene panel)				21903995;22574174		False	3	50;50;0	5.10	True		ENSG00000107611	ENSG00000107611	HGNC:2548													
DAAM2	gene	DAAM2	Expert Review Green;Literature	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	steroid-resistant nephrotic syndrome MONDO:0044765				33232676		False	3	100;0;0	5.10	False		ENSG00000146122	ENSG00000146122	HGNC:18143													
DGKE	gene	DGKE	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Nephrotic syndrome, type 7, OMIM:615008				23274426;23542698		False	3	50;50;0	5.10	False		ENSG00000153933	ENSG00000153933	HGNC:2852													
DLC1	gene	DLC1	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Childhood and adult SSNS and SRNS				29773874		False	3	100;0;0	5.10	False		ENSG00000164741	ENSG00000164741	HGNC:2897													
FAT1	gene	FAT1	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Glomerulotubular nephropathy				26905694		False	3	100;0;0	5.10	False		ENSG00000083857	ENSG00000083857	HGNC:3595													
FN1	gene	FN1	Expert list;Expert Review Green	Proteinuric renal disease		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Glomerulopathy with fibronectin deposits 2, OMIM:601894				18268355;27056061;31419955		False	3	100;0;0	5.10	False		ENSG00000115414	ENSG00000115414	HGNC:3778													
GLA	gene	GLA	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)	Fabry disease 301500				2539398;7504405;12786754		False	3	100;0;0	5.10	False		ENSG00000102393	ENSG00000102393	HGNC:4296													
GON7	gene	GON7	Expert Review Green;Literature	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Galloway-Mowat syndrome MONDO:0009627				31481669		False	3	50;50;0	5.10	False		ENSG00000170270	ENSG00000170270	HGNC:20356													
INF2	gene	INF2	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Glomerulosclerosis, focal segmental, 5 #613237;Adult onset nephrotic syndrome (+CMT);FSGS;proteinuria;renal failure				20023659;25165188		False	3	100;0;0	5.10	True	Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments	ENSG00000203485	ENSG00000203485	HGNC:23791													
ITGA3	gene	ITGA3	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital #614748						False	3	0;100;0	5.10	True		ENSG00000005884	ENSG00000005884	HGNC:6139													
ITSN1	gene	ITSN1	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Early childhood SSNS				29773874		False	3	100;0;0	5.10	False		ENSG00000205726	ENSG00000205726	HGNC:6183													
LAGE3	gene	LAGE3	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	X-LINKED: hemizygous mutation in males, biallelic mutations in females	Galloway-Mowat syndrome 2, X-linked, OMIM:301006				28805828		False	3	100;0;0	5.10	False		ENSG00000196976	ENSG00000196976	HGNC:26058													
LAMB2	gene	LAMB2	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Nephrotic syndrome, type 5, with or without ocular abnormalities #614199;Pierson syndrome #609049				20556798		False	3	100;0;0	5.10	True		ENSG00000172037	ENSG00000172037	HGNC:6487													
LCAT	gene	LCAT	Expert Review;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Norum disease, OMIM:245900;Norum disease, MONDO:0009515;LCAT DEFICIENCY				21315357;30201532;29535099;22108153;28508023;25657982;9884427		False	3	67;33;0	5.10	False		ENSG00000213398	ENSG00000213398	HGNC:6522													
LMX1B	gene	LMX1B	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Nail-patella syndrome #161200;FSGS;proteinuria;kidney failure;isolated glomerulopathy				18414507;2368736;24042019		False	3	100;0;0	5.10	True	Other - please provide details in the comments	ENSG00000136944	ENSG00000136944	HGNC:6654													
MAGI2	gene	MAGI2	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Nephrotic syndrome, type 15 617609				29773874;27932480		False	3	100;0;0	5.10	False		ENSG00000187391	ENSG00000187391	HGNC:18957													
MYH9	gene	MYH9	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Epstein syndrome #153650;Fechtner syndrome #153640				12792306;22627578;10973259;24186861		False	3	100;0;0	5.10	True		ENSG00000100345	ENSG00000100345	HGNC:7579													
MYO1E	gene	MYO1E	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Glomerulosclerosis, focal segmental, 6 #614131				21697813;23595123		False	3	100;0;0	5.10	True		ENSG00000157483	ENSG00000157483	HGNC:7599													
NOS1AP	gene	NOS1AP	Expert Review Green;Literature;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Nephrotic syndrome, type 22, OMIM:619155				33523862		False	3	100;0;0	5.10	False		ENSG00000198929	ENSG00000198929	HGNC:16859													
NPHS1	gene	NPHS1	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Nephrotic syndrome, type 1 #602716						False	3	100;0;0	5.10	True		ENSG00000161270	ENSG00000161270	HGNC:7908													
NPHS2	gene	NPHS2	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Nephrotic syndrome, type 2 #600995						False	3	100;0;0	5.10	True		ENSG00000116218	ENSG00000116218	HGNC:13394													
NUP107	gene	NUP107	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Nephrotic syndrome, type 11 #616730				26411495;30179222		False	3	100;0;0	5.10	False		ENSG00000111581	ENSG00000111581	HGNC:29914													
NUP133	gene	NUP133	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	?Galloway-Mowat syndrome 8 618349;Nephrotic syndrome, type 18 618177				30179222;30427554		False	3	100;0;0	5.10	False		ENSG00000069248	ENSG00000069248	HGNC:18016													
NUP85	gene	NUP85	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Nephrotic syndrome, type 17 #618176				30179222		False	3	100;0;0	5.10	False		ENSG00000125450	ENSG00000125450	HGNC:8734													
NUP93	gene	NUP93	Expert Review Green;Literature;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome;Nephrotic syndrome, type 12 #616892				26411495;26878725		False	3	100;0;0	5.10	True		ENSG00000102900	ENSG00000102900	HGNC:28958													
OCRL	gene	OCRL	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)	Lowe syndrome, OMIM:309000;Dent disease 2, OMIM:300555				21249396;17384968;27625797		False	3	100;0;0	5.10	False		ENSG00000122126	ENSG00000122126	HGNC:8108													
OSGEP	gene	OSGEP	Expert Review Green;Literature;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	"Galloway-Mowat syndrome 3	617729"				28805828		False	3	100;0;0	5.10	True		ENSG00000092094	ENSG00000092094	HGNC:18028													
PAX2	gene	PAX2	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Glomerulosclerosis, focal segmental, 7 #616002				26571382		False	3	100;0;0	5.10	False		ENSG00000075891	ENSG00000075891	HGNC:8616													
PDSS2	gene	PDSS2	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Coenzyme Q10 deficiency, primary, 3 #614652;Leigh syndrome				23926186;29032433;25349199;17186472;18437205		False	3	50;50;0	5.10	True		ENSG00000164494	ENSG00000164494	HGNC:23041													
PLCE1	gene	PLCE1	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Nephrotic syndrome, type 3 #610725;Congenital nephrotic syndrome/SRNS				20591883		False	3	100;0;0	5.10	True		ENSG00000138193	ENSG00000138193	HGNC:17175													
PODXL	gene	PODXL	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Congenital nephrotic syndrome				30523047;29244787;28117080;24048372		False	3	100;0;0	5.10	False		ENSG00000128567	ENSG00000128567	HGNC:9171													
PRDM15	gene	PRDM15	Expert Review Green;Literature;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	steroid-resistant nephrotic syndrome, MONDO:0044765				31950080;33593823		False	3	50;50;0	5.10	False		ENSG00000141956	ENSG00000141956	HGNC:13999													
SCARB2	gene	SCARB2	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Action myoclonus renal failure syndrome;Epilepsy, progressive myoclonic 4, with or without renal failure #254900				22032306		False	3	100;0;0	5.10	True		ENSG00000138760	ENSG00000138760	HGNC:1665													
SGPL1	gene	SGPL1	Expert Review Green;Literature;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	"Nephrotic syndrome 14	617575"				28181337; 28165339; 28165343		False	3	100;0;0	5.10	False		ENSG00000166224	ENSG00000166224	HGNC:10817													
SMARCAL1	gene	SMARCAL1	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Schimke immunoosseous dysplasia, OMIM:242900				11799392;24589093		False	3	100;0;0	5.10	True		ENSG00000138375	ENSG00000138375	HGNC:11102													
TBC1D8B	gene	TBC1D8B	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)	Nephrotic syndrome, type 20, OMIM:301028				30661770		False	3	100;0;0	5.10	False		ENSG00000133138	ENSG00000133138	HGNC:24715													
TNS2	gene	TNS2	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	nephrotic syndrome				29773874		False	3	100;0;0	5.10	False		ENSG00000111077	ENSG00000111077	HGNC:19737													
TP53RK	gene	TP53RK	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Galloway-Mowat syndrome 4 #617730				28805828		False	3	100;0;0	5.10	False		ENSG00000172315	ENSG00000172315	HGNC:16197													
TPRKB	gene	TPRKB	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Galloway-Mowat syndrome 5, OMIM:617731				28805828;30053862		False	3	50;50;0	5.10	False		ENSG00000144034	ENSG00000144034	HGNC:24259													
TRIM8	gene	TRIM8	Expert Review Green;Literature	Proteinuric renal disease		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	nephrotic syndrome;epilepsy;Focal segmental glomerulosclerosis and neurodevelopmental syndrome, OMIM:619428				33508234;32531461;32193649;33508234		False	3	100;0;0	5.10	False	Other	ENSG00000171206	ENSG00000171206	HGNC:15579													
TRPC6	gene	TRPC6	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Glomerulosclerosis, focal segmental, 2 #603652;Proteinuria;FSGS;kidney failure;Familial and sporadic SRNS (adult)				15879175		False	3	100;0;0	5.10	True		ENSG00000137672	ENSG00000137672	HGNC:12338													
VIPAS39	gene	VIPAS39	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Arthrogryposis, renal dysfunction, and cholestasis 2, OMIM:613404				39736737;35151346;37202112;26019847;24071963;31479177		False	3	50;50;0	5.10	False		ENSG00000151445	ENSG00000151445	HGNC:20347													
WDR73	gene	WDR73	Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Galloway-Mowat syndrome 1 #251300				26123727;25466283		False	3	100;0;0	5.10	False		ENSG00000177082	ENSG00000177082	HGNC:25928													
WT1	gene	WT1	Eligibility statement prior genetic testing;Expert Review Green;NHS GMS	Proteinuric renal disease		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Denys-Drash syndrome #194080;Frasier syndrome #136680;Wilms tumor, type 1 #194070				24402088		False	3	100;0;0	5.10	True		ENSG00000184937	ENSG00000184937	HGNC:12796													
YRDC	gene	YRDC	Expert Review Green;Literature	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Galloway-Mowat syndrome MONDO:0009627				31481669		False	3	50;50;0	5.10	False		ENSG00000196449	ENSG00000196449	HGNC:28905													
ANLN	gene	ANLN	Expert Review Amber;Literature;NHS GMS	Proteinuric renal disease		Renal	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	"	Focal segmental glomerulosclerosis 8	616032"				24676636;30002222		False	2	0;50;50	5.10	False		ENSG00000011426	ENSG00000011426	HGNC:14082													
APOL1	gene	APOL1	Eligibility statement prior genetic testing;Expert Review Amber;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	{Focal Segmental Glomerulosclerosis 4, Susceptibility to} OMIM:612551;{End-stage renal disease, nondiabetic, susceptibility to} OMIM:612551				20647424;23766536;33517446		False	2	25;50;25	5.10	True	Other	ENSG00000100342	ENSG00000100342	HGNC:618													
EMP2	gene	EMP2	Expert Review Amber;Literature;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	steroid sensitive nephrotic syndrome;Nephrotic syndrome, type 10 #615861				24814193		False	2	50;25;25	5.10	False		ENSG00000213853	ENSG00000213853	HGNC:3334													
KANK2	gene	KANK2	Expert Review Amber;Literature;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome;Nephrotic syndrome 16 #617783				25961457		False	2	50;50;0	5.10	True		ENSG00000197256	ENSG00000197256	HGNC:29300													
KAT2B	gene	KAT2B	Expert Review Amber;Literature	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	steroid-resistant nephrotic syndrome, MONDO:0044765				39366742;29768408		False	2	0;100;0	5.10	False		ENSG00000114166	ENSG00000114166	HGNC:8638													
KIRREL1	gene	KIRREL1	Expert Review Amber;Literature	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	steroid-resistant nephrotic syndrome MONDO:0044765				31472902		False	2	0;100;0	5.10	False		ENSG00000183853	ENSG00000183853	HGNC:15734													
LAMA5	gene	LAMA5	Expert Review Amber;NHS GMS	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Nephrotic syndrome				29534211		False	2	0;50;50	5.10	False		ENSG00000130702	ENSG00000130702	HGNC:6485													
PTPRO	gene	PTPRO	Eligibility statement prior genetic testing;Expert Review Amber;NHS GMS	Proteinuric renal disease		Renal		Nephrotic syndrome, type 6 #614196				21722858;30065916		False	2	33;67;0	5.10	True		ENSG00000151490	ENSG00000151490	HGNC:9678													
RCAN1	gene	RCAN1	Expert Review Amber;Literature	Proteinuric renal disease		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	focal segmental glomerulosclerosis, MONDO:0100313;nephrotic syndrome, MONDO:0005377				33863784		False	2	0;100;0	5.10	False		ENSG00000159200	ENSG00000159200	HGNC:3040													
ALG1	gene	ALG1	Eligibility statement prior genetic testing;Expert Review Red;NHS GMS	Proteinuric renal disease		Renal		Congenital disorder of glycosylation, type Ik #608540				27325525		False	1	0;100;0	5.10	True		ENSG00000033011	ENSG00000033011	HGNC:18294													
ALMS1	gene	ALMS1	Eligibility statement prior genetic testing;Expert Review Red;NHS GMS	Proteinuric renal disease		Renal		Alstrom Syndrome #203800				25846608		False	1	0;100;0	5.10	True		ENSG00000116127	ENSG00000116127	HGNC:428													
ANKFY1	gene	ANKFY1	NHS GMS	Proteinuric renal disease		Renal						29959197		False	1	0;0;100	5.10	False		ENSG00000185722	ENSG00000185722	HGNC:20763													
ARHGAP24	gene	ARHGAP24	Eligibility statement prior genetic testing;Expert Review Red;NHS GMS	Proteinuric renal disease		Renal		Focal segmental glomerulosclerosis				21911940		False	1	0;50;50	5.10	True		ENSG00000138639	ENSG00000138639	HGNC:25361													
CDK20	gene	CDK20	NHS GMS	Proteinuric renal disease		Renal		Chronic kidney disease				29773874		False	1	0;0;100	5.10	False		ENSG00000156345	ENSG00000156345	HGNC:21420													
COL4A1	gene	COL4A1	NHS GMS	Proteinuric renal disease		Renal		Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps #611773				27190376		False	1	0;0;100	5.10	False		ENSG00000187498	ENSG00000187498	HGNC:2202													
COQ7	gene	COQ7	NHS GMS	Proteinuric renal disease		Renal		?Coenzyme Q10 deficiency, primary, 8 #616733				26084283		False	1	0;0;100	5.10	False		ENSG00000167186	ENSG00000167186	HGNC:2244													
COQ9	gene	COQ9	NHS GMS	Proteinuric renal disease		Renal		Coenzyme Q10 deficiency, primary, 5 #614654				19375058		False	1	0;0;100	5.10	False		ENSG00000088682	ENSG00000088682	HGNC:25302													
CYP11B2	gene	CYP11B2	Eligibility statement prior genetic testing;Expert Review Red;NHS GMS	Proteinuric renal disease		Renal		Hypoaldosteronism, congenital, due to CMO I deficiency #203400;Hypoaldosteronism, congenital, due to CMO II deficiency #610600				9814506;24022297		False	1	0;50;50	5.10	True		ENSG00000179142	ENSG00000179142	HGNC:2592													
DHFR	gene	DHFR	Expert Review Red;NHS GMS;Radboud University Medical Center, Nijmegen	Proteinuric renal disease		Renal		Megaloblastic anemia due to dihydrofolate reductase deficiency, 613839; (originally on the Imerslund-Grasbeck syndrome gene panel)						False	1	0;0;100	5.10	True		ENSG00000228716	ENSG00000228716	HGNC:2861													
DKC1	gene	DKC1	Expert Review Red;Literature	Proteinuric renal disease		Renal	X-LINKED: hemizygous mutation in males, biallelic mutations in females	steroid-resistant 6 nephrotic syndrome;cataracts (prior to steroid treatment);sensorineural deafness;enterocolitis				32554502		False	1	0;0;100	5.10	False		ENSG00000130826	ENSG00000130826	HGNC:2890													
E2F3	gene	E2F3	Eligibility statement prior genetic testing;Expert Review Red;NHS GMS	Proteinuric renal disease		Renal		FSGS;mental retardation				21372519		False	1	0;0;100	5.10	True		ENSG00000112242	ENSG00000112242	HGNC:3115													
GAPVD1	gene	GAPVD1	NHS GMS	Proteinuric renal disease		Renal						29959197		False	1	0;100;0	5.10	False		ENSG00000165219	ENSG00000165219	HGNC:23375													
GIF	gene	GIF	Expert Review Red;Imerslund-Grasbeck syndrome eligibility statement prior genetic testing;NHS GMS	Proteinuric renal disease		Renal		GIF mutations may phenocopy this disorder; (originally on the Imerslund-Grasbeck syndrome gene panel)						False	1	0;0;100	5.10	True		ENSG00000134812	ENSG00000134812	HGNC:4268													
IL1RAP	gene	IL1RAP	Expert Review Red;Literature	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Steroid-sensitive nephrotic syndrome				31954058		False	1	0;0;100	5.10	False		ENSG00000196083	ENSG00000196083	HGNC:5995													
ITGB4	gene	ITGB4	Eligibility statement prior genetic testing;Expert Review Red;NHS GMS	Proteinuric renal disease		Renal		Epidermolysis bullosa, junctional, with pyloric stenosis #226730				11328943		False	1	0;100;0	5.10	True		ENSG00000132470	ENSG00000132470	HGNC:6158													
ITSN2	gene	ITSN2	NHS GMS	Proteinuric renal disease		Renal		Early childhood SSNS				29773874		False	1	0;100;0	5.10	False		ENSG00000198399	ENSG00000198399	HGNC:6184													
KANK1	gene	KANK1	NHS GMS	Proteinuric renal disease		Renal		Steroid sensitive resistant nephrotic syndrome				25961457		False	1	0;0;100	5.10	False		ENSG00000107104	ENSG00000107104	HGNC:19309													
KANK4	gene	KANK4	NHS GMS	Proteinuric renal disease		Renal						25961457		False	1	0;0;100	5.10	False		ENSG00000132854	ENSG00000132854	HGNC:27263													
LMNA	gene	LMNA	NHS GMS	Proteinuric renal disease		Renal		Partial lipodystrophy and FSGS				24080738;28620495		False	1	0;100;0	5.10	False		ENSG00000160789	ENSG00000160789	HGNC:6636													
MAFB	gene	MAFB	NHS GMS	Proteinuric renal disease		Renal		FSGS with Duane retraction syndrome				29779709;22387013		False	1	0;100;0	5.10	False		ENSG00000204103	ENSG00000204103	HGNC:6408													
MED28	gene	MED28	NHS GMS	Proteinuric renal disease		Renal								False	1	0;0;100	5.10	False		ENSG00000118579	ENSG00000118579	HGNC:24628													
MEFV	gene	MEFV	NHS GMS	Proteinuric renal disease		Renal		Familial Mediterranean fever, AD, OMIM:134610;Familial Mediterranean fever, AR, OMIM:249100						False	1	0;100;0	5.10	False		ENSG00000103313	ENSG00000103313	HGNC:6998													
MTR	gene	MTR	Expert Review Red;NHS GMS;Radboud University Medical Center, Nijmegen	Proteinuric renal disease		Renal		Homocystinuria-megaloblastic anemia, cblG complementation type, 250940;{Neural tube defects, folate-sensitive, susceptibility to}, 601634;(originally on the Imerslund-Grasbeck syndrome gene panel)						False	1	0;50;50	5.10	True		ENSG00000116984	ENSG00000116984	HGNC:7468													
MTRR	gene	MTRR	Expert Review Red;NHS GMS;Radboud University Medical Center, Nijmegen	Proteinuric renal disease		Renal		Homocystinuria-megaloblastic anemia, cbl E type, 236270; (originally on the Imerslund-Grasbeck syndrome gene panel)						False	1	0;50;50	5.10	True		ENSG00000124275	ENSG00000124275	HGNC:7473													
NEIL1	gene	NEIL1	NHS GMS	Proteinuric renal disease		Renal		SRNS				21697813		False	1	0;0;100	5.10	False		ENSG00000140398	ENSG00000140398	HGNC:18448													
NEU1	gene	NEU1	NHS GMS	Proteinuric renal disease		Renal		SRNS				30450471		False	1	0;0;100	5.10	False		ENSG00000204386	ENSG00000204386	HGNC:7758													
NLRP3	gene	NLRP3	NHS GMS	Proteinuric renal disease		Renal	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Muckle-Wells syndrome, OMIM:191900;Renal amyloidosis				30431487		False	1	0;0;100	5.10	False		ENSG00000162711	ENSG00000162711	HGNC:16400													
NOP10	gene	NOP10	Expert Review Red;Literature	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	steroid-resistant 6 nephrotic syndrome;cataracts (prior to steroid treatment);sensorineural deafness;enterocolitis				32554502		False	1	0;0;100	5.10	False		ENSG00000182117	ENSG00000182117	HGNC:14378													
NPHP4	gene	NPHP4	NHS GMS	Proteinuric renal disease		Renal		Nephronophthisis 4 #606966				17954299;26346198		False	1	0;100;0	5.10	False		ENSG00000131697	ENSG00000131697	HGNC:19104													
NUP160	gene	NUP160	NHS GMS	Proteinuric renal disease		Renal		?Nephrotic syndrome, type 19 #618178				30179222		False	1	0;100;0	5.10	False		ENSG00000030066	ENSG00000030066	HGNC:18017													
NUP205	gene	NUP205	NHS GMS	Proteinuric renal disease		Renal		?Nephrotic syndrome, type 13 #616893				26878725		False	1	0;100;0	5.10	False		ENSG00000155561	ENSG00000155561	HGNC:18658													
NXF5	gene	NXF5	NHS GMS	Proteinuric renal disease		Renal		FSGS;heart-block disorder				23686279		False	1	0;0;100	5.10	False		ENSG00000126952	ENSG00000126952	HGNC:8075													
PMM2	gene	PMM2	Eligibility statement prior genetic testing;Expert Review Red;NHS GMS	Proteinuric renal disease		Renal		Congenital disorder of glycosylation, type Ia #212065				19474279;29229467		False	1	0;100;0	5.10	True		ENSG00000140650	ENSG00000140650	HGNC:9115													
SLC19A2	gene	SLC19A2	Expert Review Red;Illumina TruGenome Clinical Sequencing Services;NHS GMS;Radboud University Medical Center, Nijmegen;UKGTN	Proteinuric renal disease		Renal	BIALLELIC, autosomal or pseudoautosomal	Thiamine-responsive megaloblastic anemia syndrome, OMIM:249270						False	1	0;0;100	5.10	True		ENSG00000117479	ENSG00000117479	HGNC:10938													
SLC19A3	gene	SLC19A3	Expert Review Red;NHS GMS;Radboud University Medical Center, Nijmegen	Proteinuric renal disease		Renal		Thiamine metabolism dysfunction syndrome 2 (biotin- or thiamine-responsive encephalopathy type 2) #607483;(originally on the Imerslund-Grasbeck syndrome gene panel)						False	1	0;0;100	5.10	True		ENSG00000135917	ENSG00000135917	HGNC:16266													
SYNPO	gene	SYNPO	NHS GMS	Proteinuric renal disease		Renal		Focal segmental glomerulosclerosis;FSGS				19666657		False	1	0;100;0	5.10	False		ENSG00000171992	ENSG00000171992	HGNC:30672													
TTC21B	gene	TTC21B	NHS GMS	Proteinuric renal disease		Renal		Nephronophthisis 12 # 613820				26940125;24876116		False	1	0;100;0	5.10	False		ENSG00000123607	ENSG00000123607	HGNC:25660													
VPS33B	gene	VPS33B	NHS GMS	Proteinuric renal disease		Renal		Arthrogryposis, renal dysfunction, and cholestasis 1 #208085				18853461		False	1	0;100;0	5.10	False		ENSG00000184056	ENSG00000184056	HGNC:12712													
XPO5	gene	XPO5	NHS GMS	Proteinuric renal disease		Renal		Nephrotic syndrome				26878725		False	1	0;0;100	5.10	False		ENSG00000124571	ENSG00000124571	HGNC:17675													
ZMPSTE24	gene	ZMPSTE24	Eligibility statement prior genetic testing;Expert Review Red;NHS GMS	Proteinuric renal disease		Renal		Mandibuloacral dysplasia with type B lipodystrophy #608612				17152860		False	1	0;100;0	5.10	True		ENSG00000084073	ENSG00000084073	HGNC:12877