Entity Name	Entity type	Gene Symbol	Sources(; separated)	Level4	Level3	Level2	Model_Of_Inheritance	Phenotypes	Omim	Orphanet	HPO	Publications	Description	Flagged	GEL_Status	UserRatings_Green_amber_red	version	ready	Mode of pathogenicity	EnsemblId(GRch37)	EnsemblId(GRch38)	HGNC	Position Chromosome	Position GRCh37 Start	Position GRCh37 End	Position GRCh38 Start	Position GRCh38 End	STR Repeated Sequence	STR Normal Repeats	STR Pathogenic Repeats	Region Haploinsufficiency Score	Region Triplosensitivity Score	Region Required Overlap Percentage	Region Variant Type	Region Verbose Name
BUB1B	gene	BUB1B	Expert Review Green;NHS GMS	Sarcoma of possible germline origin		Inherited cancer	BIALLELIC, autosomal or pseudoautosomal	mosaic variegated aneuploidy syndrome 1, MONDO:0009759;Mosaic variegated aneuploidy syndrome 1, OMIM:257300						False	3	100;0;0	0.8	False		ENSG00000156970	ENSG00000156970	HGNC:1149													
CBL	gene	CBL	Expert Review Green;NHS GMS	Sarcoma of possible germline origin		Inherited cancer	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia, OMIM:613563;CBL-related disorder, MONDO:0013308;?Juvenile myelomonocytic leukemia, OMIM:607785						False	3	100;0;0	0.8	False		ENSG00000110395	ENSG00000110395	HGNC:1541													
DICER1	gene	DICER1	Expert Review Green;NHS GMS	Sarcoma of possible germline origin		Inherited cancer	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Pleuropulmonary blastoma, OMIM:601200;Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors, OMIM:138800;Rhabdomyosarcoma, embryonal, 2, OMIM:180295;rhabdomyosarcoma, embryonal, 2, MONDO:0859046;DICER1-related tumor predisposition, MONDO:0100216						False	3	100;0;0	0.8	False		ENSG00000100697	ENSG00000100697	HGNC:17098													
HRAS	gene	HRAS	Expert Review Green;NHS GMS	Sarcoma of possible germline origin		Inherited cancer	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Costello syndrome, MONDO:0009026;Costello syndrome, OMIM:218040						False	3	100;0;0	0.8	False		ENSG00000174775	ENSG00000174775	HGNC:5173													
KRAS	gene	KRAS	Expert Review Green;NHS GMS	Sarcoma of possible germline origin		Inherited cancer	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Noonan syndrome 3, OMIM:609942;cardiofaciocutaneous syndrome 2, MONDO:0014112;Noonan syndrome 3, MONDO:0012371;Cardiofaciocutaneous syndrome 2, OMIM:615278;RAS-associated autoimmune leukoproliferative disorder, OMIM:614470						False	3	100;0;0	0.8	False		ENSG00000133703	ENSG00000133703	HGNC:6407													
NBN	gene	NBN	Expert Review Green;NHS GMS	Sarcoma of possible germline origin		Inherited cancer	BIALLELIC, autosomal or pseudoautosomal	Nijmegen breakage syndrome, OMIM:251260;Nijmegen breakage syndrome, MONDO:0009623						False	3	100;0;0	0.8	False		ENSG00000104320	ENSG00000104320	HGNC:7652													
NF1	gene	NF1	Expert Review Green;NHS GMS	Sarcoma of possible germline origin		Inherited cancer	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	neurofibromatosis type 1, MONDO:0018975;Neurofibromatosis, type 1, OMIM:162200;neurofibromatosis-Noonan syndrome, MONDO:0011035;Neurofibromatosis, familial spinal, OMIM:162210;Leukemia, juvenile myelomonocytic, OMIM:607785;Neurofibromatosis-Noonan syndrome, OMIM:601321						False	3	100;0;0	0.8	False		ENSG00000196712	ENSG00000196712	HGNC:7765													
PTPN11	gene	PTPN11	Expert Review Green;NHS GMS	Sarcoma of possible germline origin		Inherited cancer	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Noonan syndrome 1, OMIM:163950;Noonan syndrome 1, MONDO:0008104						False	3	100;0;0	0.8	False		ENSG00000179295	ENSG00000179295	HGNC:9644													
RB1	gene	RB1	Expert Review Green;NHS GMS	Sarcoma of possible germline origin		Inherited cancer	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Retinoblastoma, OMIM:180200;Retinoblastoma, trilateral, OMIM:180200;hereditary retinoblastoma, MONDO:0018160						False	3	100;0;0	0.8	False		ENSG00000139687	ENSG00000139687	HGNC:9884													
RECQL4	gene	RECQL4	Expert Review Green;NHS GMS	Sarcoma of possible germline origin		Inherited cancer	BIALLELIC, autosomal or pseudoautosomal	Rothmund-Thomson syndrome, type 2, OMIM:268400;Rothmund-Thomson syndrome type 2, MONDO:0016369						False	3	100;0;0	0.8	False		ENSG00000160957	ENSG00000160957	HGNC:9949													
T	gene	T	Expert Review Green;NHS GMS	Sarcoma of possible germline origin		Inherited cancer	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown							False	3	100;0;0	0.8	False		ENSG00000164458	ENSG00000164458	HGNC:11515													
TP53	gene	TP53	Expert Review Green;NHS GMS	Sarcoma of possible germline origin		Inherited cancer	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	{Colorectal cancer}, OMIM:114500;basal cell carcinoma, susceptibility to, 7, MONDO:0013876;adrenocortical carcinoma, hereditary, MONDO:0008734;{Glioma susceptibility 1}, OMIM:137800;nasopharyngeal carcinoma, susceptibility to, 1, MONDO:0011775;Li-Fraumeni syndrome, OMIM:151623;Li-Fraumeni syndrome, MONDO:0018875;{Basal cell carcinoma 7}, OMIM:614740;choroid plexus papilloma, MONDO:0009837;{Adrenocortical carcinoma, pediatric}, OMIM:202300;{Choroid plexus papilloma}, OMIM:260500						False	3	100;0;0	0.8	False		ENSG00000141510	ENSG00000141510	HGNC:11998													
WRN	gene	WRN	Expert Review Green;NHS GMS	Sarcoma of possible germline origin		Inherited cancer	BIALLELIC, autosomal or pseudoautosomal	Werner syndrome, MONDO:0010196;Werner syndrome, OMIM:277700						False	3	100;0;0	0.8	False		ENSG00000165392	ENSG00000165392	HGNC:12791