Entity Name	Entity type	Gene Symbol	Sources(; separated)	Level4	Level3	Level2	Model_Of_Inheritance	Phenotypes	Omim	Orphanet	HPO	Publications	Description	Flagged	GEL_Status	UserRatings_Green_amber_red	version	ready	Mode of pathogenicity	EnsemblId(GRch37)	EnsemblId(GRch38)	HGNC	Position Chromosome	Position GRCh37 Start	Position GRCh37 End	Position GRCh38 Start	Position GRCh38 End	STR Repeated Sequence	STR Normal Repeats	STR Pathogenic Repeats	Region Haploinsufficiency Score	Region Triplosensitivity Score	Region Required Overlap Percentage	Region Variant Type	Region Verbose Name
APCDD1	gene	APCDD1	Expert Review Green;Other;Radboud University Medical Center, Nijmegen	Non-syndromic hypotrichosis	Skin adnexa disorders	Dermatological disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Hereditary hypotrichosis simplex (HHS); Hypotrichosis simplex (HS); Hypotrichosis 1; non-syndromic hereditary hypotrichosis; Hypotrichosis 1, 605389				22512811; 20393562		False	3	100;0;0	1.15	False		ENSG00000154856	ENSG00000154856	HGNC:15718													
CDSN	gene	CDSN	Expert Review Green;Other;Radboud University Medical Center, Nijmegen	Non-syndromic hypotrichosis	Skin adnexa disorders	Dermatological disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Hypotrichosis 2, OMIM:146520				12754508;23746069;22875505		False	3	100;0;0	1.15	False		ENSG00000204539	ENSG00000204539	HGNC:1802													
DSG4	gene	DSG4	Expert Review Green;Illumina TruGenome Clinical Sequencing Services;Other;Radboud University Medical Center, Nijmegen	Non-syndromic hypotrichosis	Skin adnexa disorders	Dermatological disorders	BIALLELIC, autosomal or pseudoautosomal	Hereditary hypotrichosis simplex (HHS);Hypotrichosis simplex (HS);localized autosomal recessive hypotrichosis-1 (LAH1);Autosomal recessive hypotrichosis;Hypotrichosis 6, 607903;HYPT6;Localized AR Hypotrichosis;localized autosomal recessive hypotrichosis;Hypotrichosis with broken hairs and follicular hyperkeratosis (variable severity and extent)				15304105		False	3	100;0;0	1.15	False		ENSG00000175065	ENSG00000175065	HGNC:21307													
HR	gene	HR	Expert Review Green;Other;Radboud University Medical Center, Nijmegen	Non-syndromic hypotrichosis	Skin adnexa disorders	Dermatological disorders	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Alopecia universalis, OMIM:203655;Atrichia with papular lesions, OMIM:209500						False	3	100;0;0	1.15	False	Other - please provide details in the comments	ENSG00000168453	ENSG00000168453	HGNC:5172													
KRT74	gene	KRT74	Expert Review Green;Other;Radboud University Medical Center, Nijmegen	Non-syndromic hypotrichosis	Skin adnexa disorders	Dermatological disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Hypotrichosis 3, OMIM:613981;HYPT3				21188418		False	3	100;0;0	1.15	False		ENSG00000170484	ENSG00000170484	HGNC:28929													
LIPH	gene	LIPH	Expert Review Green;Other;Radboud University Medical Center, Nijmegen	Non-syndromic hypotrichosis	Skin adnexa disorders	Dermatological disorders	BIALLELIC, autosomal or pseudoautosomal	Hereditary hypotrichosis simplex (HHS);Hypotrichosis simplex (HS);localized autosomal recessive hypotrichosis-2 (LAH2);Autosomal recessive hypotrichosis;Hypotrichosis 7, 604379;HYPT7;Woolly hair, autosomal recessive 2 with or without hypotrichosis, 604379						False	3	100;0;0	1.15	False		ENSG00000163898	ENSG00000163898	HGNC:18483													
LPAR6	gene	LPAR6	Expert Review Green;Other;Radboud University Medical Center, Nijmegen	Non-syndromic hypotrichosis	Skin adnexa disorders	Dermatological disorders	BIALLELIC, autosomal or pseudoautosomal	Hypotrichosis 8, 278150;Hereditary hypotrichosis simplex (HHS);Hypotrichosis simplex (HS);localized autosomal recessive hypotrichosis-3 (LAH3);Autosomal recessive hypotrichosis;Hypotrichosis 8;HYPT8;Woolly hair, autosomal recessive 1, with or without hypotrichosis, 278150				21070332; 21426374; 18461368		False	3	100;0;0	1.15	False		ENSG00000139679	ENSG00000139679	HGNC:15520													
LSS	gene	LSS	Expert Review Green;Literature	Non-syndromic hypotrichosis	Skin adnexa disorders	Dermatological disorders	BIALLELIC, autosomal or pseudoautosomal	Hypotrichosis 14 OMIM:618275;hypotrichosis 14 MONDO:0032649				32101538;30401459;30723320;29016354		False	3	100;0;0	1.15	False		ENSG00000160285	ENSG00000160285	HGNC:6708													
C3orf52	gene	C3orf52	Expert Review Amber;Literature	Non-syndromic hypotrichosis	Skin adnexa disorders	Dermatological disorders	BIALLELIC, autosomal or pseudoautosomal	Hypotrichosis 15, OMIM:620177				32336749		False	2	0;100;0	1.15	False		ENSG00000114529	ENSG00000114529	HGNC:26255													
SNRPE	gene	SNRPE	Expert Review Amber;Other;Radboud University Medical Center, Nijmegen	Non-syndromic hypotrichosis	Skin adnexa disorders	Dermatological disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Hypotrichosis 11, OMIM:615059				23246290		False	2	0;100;0	1.15	False		ENSG00000182004	ENSG00000182004	HGNC:11161													
DSC3	gene	DSC3	Expert Review Red;Other;Radboud University Medical Center, Nijmegen	Non-syndromic hypotrichosis	Skin adnexa disorders	Dermatological disorders	BIALLELIC, autosomal or pseudoautosomal	hypotrichosis and recurrent skin vesicles disorder, 613102; HRSV;?Hypotrichosis and recurrent skin vesicles, 613102				19765682		False	1	0;0;100	1.15	False		ENSG00000134762	ENSG00000134762	HGNC:3037													
KRT71	gene	KRT71	Expert Review Red;Other;Radboud University Medical Center, Nijmegen	Non-syndromic hypotrichosis	Skin adnexa disorders	Dermatological disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	?Hypotrichosis 13, 615896;HYPT13;woolly hair;hypotrichosis				22592156		False	1	0;0;100	1.15	False		ENSG00000139648	ENSG00000139648	HGNC:28927													
RPL21	gene	RPL21	Expert Review Red;Other;Radboud University Medical Center, Nijmegen	Non-syndromic hypotrichosis	Skin adnexa disorders	Dermatological disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Hereditary hypotrichosis simplex (HHS); Hypotrichosis simplex (HS); HYPT12; Hypotrichosis 12, 615885				21412954		False	1	0;0;100	1.15	False		ENSG00000122026	ENSG00000122026	HGNC:10313