Entity Name Entity type Gene Symbol Sources(; separated) Level4 Level3 Level2 Model_Of_Inheritance Phenotypes Omim Orphanet HPO Publications Description Flagged GEL_Status UserRatings_Green_amber_red version ready Mode of pathogenicity EnsemblId(GRch37) EnsemblId(GRch38) HGNC Position Chromosome Position GRCh37 Start Position GRCh37 End Position GRCh38 Start Position GRCh38 End STR Repeated Sequence STR Normal Repeats STR Pathogenic Repeats Region Haploinsufficiency Score Region Triplosensitivity Score Region Required Overlap Percentage Region Variant Type Region Verbose Name ALKBH2 gene ALKBH2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Direct reversal of damage;Activity: 1-meA dioxygenase False 1 0;0;0 1.1 False ENSG00000189046 ENSG00000189046 HGNC:32487 ALKBH3 gene ALKBH3 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Direct reversal of damage;Activity: 1-meA dioxygenase False 1 0;0;0 1.1 False ENSG00000166199 ENSG00000166199 HGNC:30141 APEX1 gene APEX1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other BER and strand break joining factors;Activity: AP endonuclease False 1 0;0;0 1.1 False ENSG00000100823 ENSG00000100823 HGNC:587 APEX2 gene APEX2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other BER and strand break joining factors;Activity: AP endonuclease False 1 0;0;0 1.1 False ENSG00000169188 ENSG00000169188 HGNC:17889 APLF gene APLF Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other BER and strand break joining factors;Activity: Accessory factor for DNA end-joining False 1 0;0;0 1.1 False ENSG00000169621 ENSG00000169621 HGNC:28724 APTX gene APTX Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Editing and processing nucleases;Activity: Processing of DNA single-strand interruptions False 1 0;0;0 1.1 False ENSG00000137074 ENSG00000137074 HGNC:15984 ATM gene ATM Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Genes defective in diseases associated with sensitivity to DNA damaging agents;Activity: ataxia telangiectasia False 1 0;0;0 1.1 False ENSG00000149311 ENSG00000149311 HGNC:795 ATR gene ATR Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: ATM- and PI-3K-like essential kinase False 1 0;0;0 1.1 False ENSG00000175054 ENSG00000175054 HGNC:882 ATRIP gene ATRIP Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: ATR-interacting protein False 1 0;0;0 1.1 False ENSG00000164053 ENSG00000164053 HGNC:33499 BLM gene BLM Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Genes defective in diseases associated with sensitivity to DNA damaging agents;Activity: Bloom syndrome helicase False 1 0;0;0 1.1 False ENSG00000197299 ENSG00000197299 HGNC:1058 BRCA1 gene BRCA1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: Accessory factor for transcription and recombination, E3 Ubiquitin ligase False 1 0;0;0 1.1 False ENSG00000012048 ENSG00000012048 HGNC:1100 BRCA2 gene BRCA2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia;Tolerance and repair of DNA crosslinks and other adducts in DNA: Cooperation with RAD51, essential function False 1 0;0;0 1.1 False ENSG00000139618 ENSG00000139618 HGNC:1101 BRIP1 gene BRIP1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia;Tolerance and repair of DNA crosslinks and other adducts in DNA: DNA helicase, BRCA1-interacting False 1 0;0;0 1.1 False ENSG00000136492 ENSG00000136492 HGNC:20473 CCNH gene CCNH Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Kinase subunits of TFIIH False 1 0;0;0 1.1 False ENSG00000134480 ENSG00000134480 HGNC:1594 CDK7 gene CDK7 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Kinase subunits of TFIIH False 1 0;0;0 1.1 False ENSG00000134058 ENSG00000134058 HGNC:1778 CETN2 gene CETN2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Binds DNA distortions False 1 0;0;0 1.1 False ENSG00000147400 ENSG00000147400 HGNC:1867 CHAF1A gene CHAF1A Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Chromatin Structure and Modification;Activity: Chromatin assembly factor False 1 0;0;0 1.1 False ENSG00000167670 ENSG00000167670 HGNC:1910 CHEK1 gene CHEK1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: Effector kinases False 1 0;0;0 1.1 False ENSG00000149554 ENSG00000149554 HGNC:1925 CHEK2 gene CHEK2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: Effector kinases False 1 0;0;0 1.1 False ENSG00000183765 ENSG00000183765 HGNC:16627 CLK2 gene CLK2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: S-phase check point and biological clock protein False 1 0;0;0 1.1 False ENSG00000176444 ENSG00000176444 HGNC:2069 DCLRE1A gene DCLRE1A Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other identified genes with known or suspected DNA repair function;Activity: DNA crosslink repair False 1 0;0;0 1.1 False ENSG00000198924 ENSG00000198924 HGNC:17660 DCLRE1B gene DCLRE1B Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other identified genes with known or suspected DNA repair function;Activity: Related to SNM1 False 1 0;0;0 1.1 False ENSG00000118655 ENSG00000118655 HGNC:17641 DCLRE1C gene DCLRE1C Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Non-homologous end-joining;Activity: Nuclease False 1 0;0;0 1.1 False ENSG00000152457 ENSG00000152457 HGNC:17642 DDB1 gene DDB1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Complex defective in XP group E False 1 0;0;0 1.1 False ENSG00000167986 ENSG00000167986 HGNC:2717 DDB2 gene DDB2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Complex defective in XP group E False 1 0;0;0 1.1 False ENSG00000134574 ENSG00000134574 HGNC:2718 DMC1 gene DMC1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: Rad51 homolog, meiosis False 1 0;0;0 1.1 False ENSG00000100206 ENSG00000100206 HGNC:2927 DUT gene DUT Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Modulation of nucleotide pools;Activity: dUTPase False 1 0;0;0 1.1 False ENSG00000128951 ENSG00000128951 HGNC:3078 EME1 gene EME1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: Subunits of structure-specific DNA nuclease False 1 0;0;0 1.1 False ENSG00000154920 ENSG00000154920 HGNC:24965 EME2 gene EME2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: Subunits of structure-specific DNA nuclease False 1 0;0;0 1.1 False ENSG00000197774 ENSG00000197774 HGNC:27289 ENDOV gene ENDOV Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Editing and processing nucleases;Activity: incision 3' of hypoxanthine and uracil in DNA and inosine in RNA False 1 0;0;0 1.1 False ENSG00000173818 ENSG00000173818 HGNC:26640 ERCC1 gene ERCC1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: 5' incision DNA binding subunit False 1 0;0;0 1.1 False ENSG00000012061 ENSG00000012061 HGNC:3433 ERCC2 gene ERCC2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: 5' to 3' DNA helicase False 1 0;0;0 1.1 False ENSG00000104884 ENSG00000104884 HGNC:3434 ERCC3 gene ERCC3 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: 3' to 5' DNA helicase False 1 0;0;0 1.1 False ENSG00000163161 ENSG00000163161 HGNC:3435 ERCC4 gene ERCC4 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: 5' incision catalytic subunit False 1 0;0;0 1.1 False ENSG00000175595 ENSG00000175595 HGNC:3436 ERCC5 gene ERCC5 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: 3' incision False 1 0;0;0 1.1 False ENSG00000134899 ENSG00000134899 HGNC:3437 ERCC6 gene ERCC6 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Cockayne syndrome and UV-Sensitive Syndrome; Needed for transcription-coupled NER False 1 0;0;0 1.1 False ENSG00000225830 ENSG00000225830 HGNC:3438 ERCC8 gene ERCC8 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Cockayne syndrome and UV-Sensitive Syndrome; Needed for transcription-coupled NER False 1 0;0;0 1.1 False ENSG00000049167 ENSG00000049167 HGNC:3439 EXO1 gene EXO1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Editing and processing nucleases;Activity: 5' exonuclease False 1 0;0;0 1.1 False ENSG00000174371 ENSG00000174371 HGNC:3511 FAAP20 gene FAAP20 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia;Tolerance and repair of DNA crosslinks and other adducts in DNA: FANCA - associated False 1 0;0;0 1.1 False ENSG00000162585 ENSG00000162585 HGNC:26428 FAAP24 gene FAAP24 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia;Tolerance and repair of DNA crosslinks and other adducts in DNA: FAAP24 False 1 0;0;0 1.1 False ENSG00000131944 ENSG00000131944 HGNC:28467 FAN1 gene FAN1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Editing and processing nucleases;Activity: 5' nuclease interacting with FANCD2 False 1 0;0;0 1.1 False ENSG00000198690 ENSG00000198690 HGNC:29170 FANCA gene FANCA Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia False 1 0;0;0 1.1 False ENSG00000187741 ENSG00000187741 HGNC:3582 FANCB gene FANCB Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia False 1 0;0;0 1.1 False ENSG00000181544 ENSG00000181544 HGNC:3583 FANCC gene FANCC Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia False 1 0;0;0 1.1 False ENSG00000158169 ENSG00000158169 HGNC:3584 FANCD2 gene FANCD2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia;Tolerance and repair of DNA crosslinks and other adducts in DNA: target for monoubiquitination False 1 0;0;0 1.1 False ENSG00000144554 ENSG00000144554 HGNC:3585 FANCE gene FANCE Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia False 1 0;0;0 1.1 False ENSG00000112039 ENSG00000112039 HGNC:3586 FANCF gene FANCF Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia False 1 0;0;0 1.1 False ENSG00000183161 ENSG00000183161 HGNC:3587 FANCG gene FANCG Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia False 1 0;0;0 1.1 False ENSG00000221829 ENSG00000221829 HGNC:3588 FANCI gene FANCI Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia;Tolerance and repair of DNA crosslinks and other adducts in DNA: target for monoubiquitination False 1 0;0;0 1.1 False ENSG00000140525 ENSG00000140525 HGNC:25568 FANCL gene FANCL Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia;Tolerance and repair of DNA crosslinks and other adducts in DNA: False 1 0;0;0 1.1 False ENSG00000115392 ENSG00000115392 HGNC:20748 FANCM gene FANCM Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia;Tolerance and repair of DNA crosslinks and other adducts in DNA: helicase/translocase False 1 0;0;0 1.1 False ENSG00000187790 ENSG00000187790 HGNC:23168 FEN1 gene FEN1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Editing and processing nucleases;Activity: 5' nuclease False 1 0;0;0 1.1 False ENSG00000168496 ENSG00000168496 HGNC:3650 GEN1 gene GEN1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: Nuclease cleaving Holliday junctions False 1 0;0;0 1.1 False ENSG00000178295 ENSG00000178295 HGNC:26881 GTF2H1 gene GTF2H1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Core TFIIH subunit p62 False 1 0;0;0 1.1 False ENSG00000110768 ENSG00000110768 HGNC:4655 GTF2H2 gene GTF2H2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Core TFIIH subunit p44 False 1 0;0;0 1.1 False ENSG00000145736 ENSG00000145736 HGNC:4656 GTF2H3 gene GTF2H3 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Core TFIIH subunit p34 False 1 0;0;0 1.1 False ENSG00000111358 ENSG00000111358 HGNC:4657 GTF2H4 gene GTF2H4 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Core TFIIH subunit p52 False 1 0;0;0 1.1 False ENSG00000213780 ENSG00000213780 HGNC:4658 GTF2H5 gene GTF2H5 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Core TFIIH subunit p8 False 1 0;0;0 1.1 False ENSG00000272047 ENSG00000272047 HGNC:21157 H2AFX gene H2AFX Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Chromatin Structure and Modification;Activity: Histone, phosphorylated after DNA damage False 1 0;0;0 1.1 False ENSG00000188486 ENSG00000188486 HGNC:4739 HELQ gene HELQ Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other identified genes with known or suspected DNA repair function;Activity: DNA helicase False 1 0;0;0 1.1 False ENSG00000163312 ENSG00000163312 HGNC:18536 HLTF gene HLTF Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Ubiquitination and modification;Activity: E3 ubiquitin ligase, SWI/SNF related, homolog of S. cerevisiae Rad5 False 1 0;0;0 1.1 False ENSG00000071794 ENSG00000071794 HGNC:11099 HUS1 gene HUS1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: subunits of PCNA-like sensor of damaged DNA False 1 0;0;0 1.1 False ENSG00000136273 ENSG00000136273 HGNC:5309 LIG1 gene LIG1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: DNA ligase False 1 0;0;0 1.1 False ENSG00000105486 ENSG00000105486 HGNC:6598 LIG3 gene LIG3 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other BER and strand break joining factors;Activity: DNA Ligase III False 1 0;0;0 1.1 False ENSG00000005156 ENSG00000005156 HGNC:6600 LIG4 gene LIG4 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Non-homologous end-joining;Activity: Ligase False 1 0;0;0 1.1 False ENSG00000174405 ENSG00000174405 HGNC:6601 MAD2L2 gene MAD2L2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: DNA pol zeta subunit False 1 0;0;0 1.1 False ENSG00000116670 ENSG00000116670 HGNC:6764 MBD4 gene MBD4 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Base excision repair (BER);DNA glycosylases, major altered base released:U or T opposite G at CpG sequences False 1 0;0;0 1.1 False ENSG00000129071 ENSG00000129071 HGNC:6919 MDC1 gene MDC1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: Mediator of DNA damage checkpoint False 1 0;0;0 1.1 False ENSG00000137337 ENSG00000137337 HGNC:21163 MGMT gene MGMT Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Direct reversal of damage;Activity: O6-meG alkyltransferase False 1 0;0;0 1.1 False ENSG00000170430 ENSG00000170430 HGNC:7059 MLH1 gene MLH1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Mismatch excision repair (MMR);Activity: MutL homologs, forming heterodimer False 1 0;0;0 1.1 False ENSG00000076242 ENSG00000076242 HGNC:7127 MLH3 gene MLH3 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Mismatch excision repair (MMR);Activity: MutL homologs of unknown function False 1 0;0;0 1.1 False ENSG00000119684 ENSG00000119684 HGNC:7128 MMS19 gene MMS19 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Iron-sulfur cluster loading and transport False 1 0;0;0 1.1 False ENSG00000155229 ENSG00000155229 HGNC:13824 MNAT1 gene MNAT1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. False 1 0;0;0 1.1 False ENSG00000020426 ENSG00000020426 HGNC:7181 MPG gene MPG Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Base excision repair (BER);DNA glycosylases, major altered base released:3-meA, ethenoA, hypoxanthine False 1 0;0;0 1.1 False ENSG00000103152 ENSG00000103152 HGNC:7211 MPLKIP gene MPLKIP Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Genes defective in diseases associated with sensitivity to DNA damaging agents;Activity: non-photosensitive form of trichothiodystrophy False 1 0;0;0 1.1 False ENSG00000168303 ENSG00000168303 HGNC:16002 MRE11 gene MRE11 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: 3' exonuclease, defective in ATLD (ataxia-telangiectasia-like disorder) False 1 0;0;0 1.1 False ENSG00000020922 ENSG00000020922 HGNC:7230 MSH2 gene MSH2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Mismatch excision repair (MMR);Activity: Mismatch (MSH2-MSH6) and loop (MSH2-MSH3) recognition False 1 0;0;0 1.1 False ENSG00000095002 ENSG00000095002 HGNC:7325 MSH3 gene MSH3 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Mismatch excision repair (MMR);Activity: Mismatch (MSH2-MSH6) and loop (MSH2-MSH3) recognition False 1 0;0;0 1.1 False ENSG00000113318 ENSG00000113318 HGNC:7326 MSH4 gene MSH4 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Mismatch excision repair (MMR);Activity: MutS homologs specialized for meiosis False 1 0;0;0 1.1 False ENSG00000057468 ENSG00000057468 HGNC:7327 MSH5 gene MSH5 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Mismatch excision repair (MMR);Activity: MutS homologs specialized for meiosis False 1 0;0;0 1.1 False ENSG00000204410 ENSG00000204410 HGNC:7328 MSH6 gene MSH6 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Mismatch excision repair (MMR);Activity: Mismatch (MSH2-MSH6) and loop (MSH2-MSH3) recognition False 1 0;0;0 1.1 False ENSG00000116062 ENSG00000116062 HGNC:7329 MUS81 gene MUS81 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: Subunits of structure-specific DNA nuclease False 1 0;0;0 1.1 False ENSG00000172732 ENSG00000172732 HGNC:29814 MUTYH gene MUTYH Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Base excision repair (BER);DNA glycosylases, major altered base released:A opposite 8-oxoG False 1 0;0;0 1.1 False ENSG00000132781 ENSG00000132781 HGNC:7527 NABP2 gene NABP2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other identified genes with known or suspected DNA repair function;Activity: Single-stranded DNA binding protein False 1 0;0;0 1.1 False ENSG00000139579 ENSG00000139579 HGNC:28412 NBN gene NBN Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: Mutated in Nijmegen breakage syndrome False 1 0;0;0 1.1 False ENSG00000104320 ENSG00000104320 HGNC:7652 NEIL1 gene NEIL1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Base excision repair (BER);DNA glycosylases, major altered base released:Removes thymine glycol False 1 0;0;0 1.1 False ENSG00000140398 ENSG00000140398 HGNC:18448 NEIL2 gene NEIL2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Base excision repair (BER);DNA glycosylases, major altered base released:Removes oxidative products of pyrimidines False 1 0;0;0 1.1 False ENSG00000154328 ENSG00000154328 HGNC:18956 NEIL3 gene NEIL3 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Base excision repair (BER);DNA glycosylases, major altered base released:Removes oxidative products of pyrimidines False 1 0;0;0 1.1 False ENSG00000109674 ENSG00000109674 HGNC:24573 NHEJ1 gene NHEJ1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Non-homologous end-joining;Activity: End-joining factor False 1 0;0;0 1.1 False ENSG00000187736 ENSG00000187736 HGNC:25737 NTHL1 gene NTHL1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Base excision repair (BER);DNA glycosylases, major altered base released:Ring-saturated or fragmented pyrimidines False 1 0;0;0 1.1 False ENSG00000065057 ENSG00000065057 HGNC:8028 NUDT1 gene NUDT1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Modulation of nucleotide pools;Activity: 8-oxoGTPase False 1 0;0;0 1.1 False ENSG00000106268 ENSG00000106268 HGNC:8048 OGG1 gene OGG1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Base excision repair (BER);DNA glycosylases, major altered base released:8-oxoG opposite C False 1 0;0;0 1.1 False ENSG00000114026 ENSG00000114026 HGNC:8125 PALB2 gene PALB2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia;Tolerance and repair of DNA crosslinks and other adducts in DNA: co-localizes with BRCA2 (FANCD1) False 1 0;0;0 1.1 False ENSG00000083093 ENSG00000083093 HGNC:26144 PARP1 gene PARP1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA;Activity: Protects strand interruptions False 1 0;0;0 1.1 False ENSG00000143799 ENSG00000143799 HGNC:270 PARP2 gene PARP2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA;Activity: PARP-like enzyme False 1 0;0;0 1.1 False ENSG00000129484 ENSG00000129484 HGNC:272 PARP3 gene PARP3 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA;Activity: PARP-like enzyme False 1 0;0;0 1.1 False ENSG00000041880 ENSG00000041880 HGNC:273 PCNA gene PCNA Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: Sliding clamp for pol delta and pol epsilon False 1 0;0;0 1.1 False ENSG00000132646 ENSG00000132646 HGNC:8729 PER1 gene PER1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: S-phase check point and biological clock protein False 1 0;0;0 1.1 False ENSG00000179094 ENSG00000179094 HGNC:8845 PMS1 gene PMS1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Mismatch excision repair (MMR);Activity: MutL homologs of unknown function False 1 0;0;0 1.1 False ENSG00000064933 ENSG00000064933 HGNC:9121 PMS2 gene PMS2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Mismatch excision repair (MMR);Activity: MutL homologs, forming heterodimer False 1 0;0;0 1.1 False ENSG00000122512 ENSG00000122512 HGNC:9122 PMS2P3 gene PMS2P3 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Mismatch excision repair (MMR);Activity: MutL homologs of unknown function False 1 0;0;0 1.1 False ENSG00000127957 ENSG00000127957 HGNC:9128 PNKP gene PNKP Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other BER and strand break joining factors;Activity: Converts some DNA breaks to ligatable ends False 1 0;0;0 1.1 False ENSG00000039650 ENSG00000039650 HGNC:9154 POLB gene POLB Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: BER in nuclear DNA False 1 0;0;0 1.1 False ENSG00000070501 ENSG00000070501 HGNC:9174 POLD1 gene POLD1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: NER and MMR False 1 0;0;0 1.1 False ENSG00000062822 ENSG00000062822 HGNC:9175 POLE gene POLE Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: NER and MMR False 1 0;0;0 1.1 False ENSG00000177084 ENSG00000177084 HGNC:9177 POLG gene POLG Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: BER in mitochondrial DNA False 1 0;0;0 1.1 False ENSG00000140521 ENSG00000140521 HGNC:9179 POLH gene POLH Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: xeroderma pigmentosum (XP) variant False 1 0;0;0 1.1 False ENSG00000170734 ENSG00000170734 HGNC:9181 POLI gene POLI Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: Lesion bypass False 1 0;0;0 1.1 False ENSG00000101751 ENSG00000101751 HGNC:9182 POLK gene POLK Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: Lesion bypass and NER False 1 0;0;0 1.1 False ENSG00000122008 ENSG00000122008 HGNC:9183 POLL gene POLL Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: Gap-filling during non-homologous end-joining False 1 0;0;0 1.1 False ENSG00000166169 ENSG00000166169 HGNC:9184 POLM gene POLM Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: Gap filling during non-homologous end-joining False 1 0;0;0 1.1 False ENSG00000122678 ENSG00000122678 HGNC:9185 POLN gene POLN Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: DNA crosslink repair? False 1 0;0;0 1.1 False ENSG00000130997 ENSG00000130997 HGNC:18870 POLQ gene POLQ Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: Sensitivity to ionizing radiation False 1 0;0;0 1.1 False ENSG00000051341 ENSG00000051341 HGNC:9186 PRKDC gene PRKDC Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Non-homologous end-joining;Activity: DNA-dependent protein kinase catalytic subunit False 1 0;0;0 1.1 False ENSG00000253729 ENSG00000253729 HGNC:9413 PRPF19 gene PRPF19 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other identified genes with known or suspected DNA repair function;Activity: DNA crosslink repair; binding to SETMAR False 1 0;0;0 1.1 False ENSG00000110107 ENSG00000110107 HGNC:17896 RAD1 gene RAD1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: subunits of PCNA-like sensor of damaged DNA False 1 0;0;0 1.1 False ENSG00000113456 ENSG00000113456 HGNC:9806 RAD17 gene RAD17 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: RFC-like DNA damage sensor False 1 0;0;0 1.1 False ENSG00000152942 ENSG00000152942 HGNC:9807 RAD18 gene RAD18 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Ubiquitination and modification;Activity: E3 ubiquitin ligase False 1 0;0;0 1.1 False ENSG00000070950 ENSG00000070950 HGNC:18278 RAD23A gene RAD23A Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Substitutes for RAD23B False 1 0;0;0 1.1 False ENSG00000179262 ENSG00000179262 HGNC:9812 RAD23B gene RAD23B Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Binds DNA distortions False 1 0;0;0 1.1 False ENSG00000119318 ENSG00000119318 HGNC:9813 RAD50 gene RAD50 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: ATPase in complex with MRE11A, NBS1 False 1 0;0;0 1.1 False ENSG00000113522 ENSG00000113522 HGNC:9816 RAD51 gene RAD51 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: Homologous pairing False 1 0;0;0 1.1 False ENSG00000051180 ENSG00000051180 HGNC:9817 RAD51B gene RAD51B Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: Rad51 homolog False 1 0;0;0 1.1 False ENSG00000182185 ENSG00000182185 HGNC:9822 RAD51C gene RAD51C Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia;Tolerance and repair of DNA crosslinks and other adducts in DNA: Rad51 homolog FANCO False 1 0;0;0 1.1 False ENSG00000108384 ENSG00000108384 HGNC:9820 RAD51D gene RAD51D Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: Rad51 homolog False 1 0;0;0 1.1 False ENSG00000185379 ENSG00000185379 HGNC:9823 RAD52 gene RAD52 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: Accessory factors for recombination False 1 0;0;0 1.1 False ENSG00000002016 ENSG00000002016 HGNC:9824 RAD54B gene RAD54B Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: Accessory factors for recombination False 1 0;0;0 1.1 False ENSG00000197275 ENSG00000197275 HGNC:17228 RAD54L gene RAD54L Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: Accessory factors for recombination False 1 0;0;0 1.1 False ENSG00000085999 ENSG00000085999 HGNC:9826 RAD9A gene RAD9A Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: subunits of PCNA-like sensor of damaged DNA False 1 0;0;0 1.1 False ENSG00000172613 ENSG00000172613 HGNC:9827 RBBP8 gene RBBP8 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: Promotes DNA end resection False 1 0;0;0 1.1 False ENSG00000101773 ENSG00000101773 HGNC:9891 RDM1 gene RDM1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other identified genes with known or suspected DNA repair function;Activity: Similar to RAD52 False 1 0;0;0 1.1 False ENSG00000187456 ENSG00000278023 HGNC:19950 RECQL gene RECQL Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other identified genes with known or suspected DNA repair function;Activity: DNA helicase False 1 0;0;0 1.1 False ENSG00000004700 ENSG00000004700 HGNC:9948 RECQL4 gene RECQL4 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Genes defective in diseases associated with sensitivity to DNA damaging agents;Activity: Rothmund-Thompson syndrome False 1 0;0;0 1.1 False ENSG00000160957 ENSG00000160957 HGNC:9949 RECQL5 gene RECQL5 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other identified genes with known or suspected DNA repair function;Activity: DNA helicase False 1 0;0;0 1.1 False ENSG00000108469 ENSG00000108469 HGNC:9950 REV1 gene REV1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: dCMP transferase False 1 0;0;0 1.1 False ENSG00000135945 ENSG00000135945 HGNC:14060 REV3L gene REV3L Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: DNA polymerases (catalytic subunits);Activity: DNA pol zeta catalytic subunit, essential function False 1 0;0;0 1.1 False ENSG00000009413 ENSG00000009413 HGNC:9968 RIF1 gene RIF1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: suppressor of 5'-end-resection False 1 0;0;0 1.1 False ENSG00000080345 ENSG00000080345 HGNC:23207 RNF168 gene RNF168 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Ubiquitination and modification;Activity: E3 ubiquitin ligase for DSB repair; ATM-like and RIDDLE syndrome False 1 0;0;0 1.1 False ENSG00000163961 ENSG00000163961 HGNC:26661 RNF4 gene RNF4 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Ubiquitination and modification;Activity: E3 ubiquitin ligase False 1 0;0;0 1.1 False ENSG00000063978 ENSG00000063978 HGNC:10067 RNF8 gene RNF8 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Ubiquitination and modification;Activity: E3 ubiquitin ligase for DSB repair False 1 0;0;0 1.1 False ENSG00000112130 ENSG00000112130 HGNC:10071 RPA1 gene RPA1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Binds DNA in preincision complex False 1 0;0;0 1.1 False ENSG00000132383 ENSG00000132383 HGNC:10289 RPA2 gene RPA2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Binds DNA in preincision complex False 1 0;0;0 1.1 False ENSG00000117748 ENSG00000117748 HGNC:10290 RPA3 gene RPA3 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Binds DNA in preincision complex False 1 0;0;0 1.1 False ENSG00000106399 ENSG00000106399 HGNC:10291 RPA4 gene RPA4 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other identified genes with known or suspected DNA repair function;Activity: Similar to RPA2 False 1 0;0;0 1.1 False ENSG00000204086 ENSG00000204086 HGNC:30305 RRM2B gene RRM2B Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Modulation of nucleotide pools;Activity: p53-inducible ribonucleotide reductase small subunit 2 homolog False 1 0;0;0 1.1 False ENSG00000048392 ENSG00000048392 HGNC:17296 SEM1 gene SEM1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: BRCA2 associated False 1 0;0;0 1.1 False ENSG00000127922 ENSG00000127922 HGNC:10845 SETMAR gene SETMAR Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Chromatin Structure and Modification;Activity: DNA damage-associated histone methylase and nuclease False 1 0;0;0 1.1 False ENSG00000170364 ENSG00000170364 HGNC:10762 SHPRH gene SHPRH Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Ubiquitination and modification;Activity: E3 ubiquitin ligase, SWI/SNF related, homolog of S. cerevisiae Rad5 False 1 0;0;0 1.1 False ENSG00000146414 ENSG00000146414 HGNC:19336 SLX1A gene SLX1A Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: subunit of SLX1-SLX4 structure-specific nuclease, two identical tandem genes in the human genome False 1 0;0;0 1.1 False ENSG00000132207 ENSG00000132207 HGNC:20922 SLX1B gene SLX1B Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: subunit of SLX1-SLX4 structure-specific nuclease, two identical tandem genes in the human genome False 1 0;0;0 1.1 False ENSG00000181625 ENSG00000181625 HGNC:28748 SLX4 gene SLX4 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Fanconi anemia;Tolerance and repair of DNA crosslinks and other adducts in DNA: nuclease subunit/scaffold BTBD12 (SLX4) FANCP False 1 0;0;0 1.1 False ENSG00000188827 ENSG00000188827 HGNC:23845 SMUG1 gene SMUG1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Base excision repair (BER);DNA glycosylases, major altered base released:U False 1 0;0;0 1.1 False ENSG00000123415 ENSG00000123415 HGNC:17148 SPO11 gene SPO11 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Editing and processing nucleases;Activity: endonuclease False 1 0;0;0 1.1 False ENSG00000054796 ENSG00000054796 HGNC:11250 SPRTN gene SPRTN Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Ubiquitination and modification;Activity: Reads ubiquitylation False 1 0;0;0 1.1 False ENSG00000010072 ENSG00000010072 HGNC:25356 TDG gene TDG Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Base excision repair (BER);DNA glycosylases, major altered base released:U, T or ethenoC opposite G False 1 0;0;0 1.1 False ENSG00000139372 ENSG00000139372 HGNC:11700 TDP1 gene TDP1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Repair of DNA-topoisomerase crosslinks;Activity: Removes 3'-tyrosylphosphate and 3'-phosphoglycolate from DNA; human disorder SCAN1 False 1 0;0;0 1.1 False ENSG00000042088 ENSG00000042088 HGNC:18884 TDP2 gene TDP2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Repair of DNA-topoisomerase crosslinks;Activity: 5'- and 3'-tyrosyl DNA phosphodiesterase False 1 0;0;0 1.1 False ENSG00000111802 ENSG00000111802 HGNC:17768 TOPBP1 gene TOPBP1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: DNA damage checkpoint control False 1 0;0;0 1.1 False ENSG00000163781 ENSG00000163781 HGNC:17008 TP53 gene TP53 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: Regulation of the cell cycle False 1 0;0;0 1.1 False ENSG00000141510 ENSG00000141510 HGNC:11998 TP53BP1 gene TP53BP1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other conserved DNA damage response genes;Activity: chromatin-binding checkpoint protein False 1 0;0;0 1.1 False ENSG00000067369 ENSG00000067369 HGNC:11999 TREX1 gene TREX1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Editing and processing nucleases;Activity: 3' exonuclease False 1 0;0;0 1.1 False ENSG00000213689 ENSG00000213689 HGNC:12269 TREX2 gene TREX2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Editing and processing nucleases;Activity: 3' exonuclease False 1 0;0;0 1.1 False ENSG00000183479 ENSG00000183479 HGNC:12270 UBE2A gene UBE2A Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Ubiquitination and modification;Activity: Ubiquitin-conjugating enzyme False 1 0;0;0 1.1 False ENSG00000077721 ENSG00000077721 HGNC:12472 UBE2B gene UBE2B Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Ubiquitination and modification;Activity: Ubiquitin-conjugating enzyme False 1 0;0;0 1.1 False ENSG00000119048 ENSG00000119048 HGNC:12473 UBE2N gene UBE2N Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Ubiquitination and modification;Activity: Ubiquitin-conjugating complex False 1 0;0;0 1.1 False ENSG00000177889 ENSG00000177889 HGNC:12492 UBE2V2 gene UBE2V2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Ubiquitination and modification;Activity: Ubiquitin-conjugating complex False 1 0;0;0 1.1 False ENSG00000169139 ENSG00000169139 HGNC:12495 UNG gene UNG Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Base excision repair (BER);DNA glycosylases, major altered base released:U False 1 0;0;0 1.1 False ENSG00000076248 ENSG00000076248 HGNC:12572 UVSSA gene UVSSA Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: 4p16.3 False 1 0;0;0 1.1 False ENSG00000163945 ENSG00000163945 HGNC:29304 WRN gene WRN Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Genes defective in diseases associated with sensitivity to DNA damaging agents;Activity: Werner syndrome helicase / 3' - exonuclease False 1 0;0;0 1.1 False ENSG00000165392 ENSG00000165392 HGNC:12791 XAB2 gene XAB2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: XAB2 False 1 0;0;0 1.1 False ENSG00000076924 ENSG00000076924 HGNC:14089 XPA gene XPA Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Binds damaged DNA in preincision complex False 1 0;0;0 1.1 False ENSG00000136936 ENSG00000136936 HGNC:12814 XPC gene XPC Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Nucleotide excision repair (NER);Activity: Binds DNA distortions False 1 0;0;0 1.1 False ENSG00000154767 ENSG00000154767 HGNC:12816 XRCC1 gene XRCC1 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Other BER and strand break joining factors;Activity: LIG3 accessory factor False 1 0;0;0 1.1 False ENSG00000073050 ENSG00000073050 HGNC:12828 XRCC2 gene XRCC2 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: DNA break and crosslink repair False 1 0;0;0 1.1 False ENSG00000196584 ENSG00000196584 HGNC:12829 XRCC3 gene XRCC3 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Homologous recombination;Activity: DNA break and crosslink repair False 1 0;0;0 1.1 False ENSG00000126215 ENSG00000126215 HGNC:12830 XRCC4 gene XRCC4 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Non-homologous end-joining;Activity: Ligase accessory factor False 1 0;0;0 1.1 False ENSG00000152422 ENSG00000152422 HGNC:12831 XRCC5 gene XRCC5 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Non-homologous end-joining;Activity: DNA end binding subunit False 1 0;0;0 1.1 False ENSG00000079246 ENSG00000079246 HGNC:12833 XRCC6 gene XRCC6 Human DNA Repair Genes Database DNA Repair Genes pertinent cancer susceptibility Pertinent cancer susceptibility gene panel Cancer Programme Class: Non-homologous end-joining;Activity: DNA end binding subunit False 1 0;0;0 1.1 False ENSG00000196419 ENSG00000196419 HGNC:4055