Entity Name	Entity type	Gene Symbol	Sources(; separated)	Level4	Level3	Level2	Model_Of_Inheritance	Phenotypes	Omim	Orphanet	HPO	Publications	Description	Flagged	GEL_Status	UserRatings_Green_amber_red	version	ready	Mode of pathogenicity	EnsemblId(GRch37)	EnsemblId(GRch38)	HGNC	Position Chromosome	Position GRCh37 Start	Position GRCh37 End	Position GRCh38 Start	Position GRCh38 End	STR Repeated Sequence	STR Normal Repeats	STR Pathogenic Repeats	Region Haploinsufficiency Score	Region Triplosensitivity Score	Region Required Overlap Percentage	Region Variant Type	Region Verbose Name
AR	gene	AR	Expert Review;Expert Review Red	Amyotrophic lateral sclerosis/motor neuron disease	Neurodegenerative disorders	Neurology and neurodevelopmental disorders	Other	Spinal and bulbar muscular atrophy of Kennedy, OMIM:313200						False	1	100;0;0	1.74	True	Other - please provide details in the comments	ENSG00000169083	ENSG00000169083	HGNC:644													
ATXN2	gene	ATXN2	Expert Review Red;Radboud University Medical Center, Nijmegen	Amyotrophic lateral sclerosis/motor neuron disease	Neurodegenerative disorders	Neurology and neurodevelopmental disorders	Other	{Amyotrophic lateral sclerosis, susceptibility to, 13}, OMIM:183090				24488689		False	1	0;0;0	1.74	False	Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments	ENSG00000204842	ENSG00000204842	HGNC:10555													
C9orf72	gene	C9orf72	 Eligibility statement prior genetic testing;Expert;Expert Review Red;Illumina TruGenome Clinical Sequencing Services;Radboud University Medical Center, Nijmegen	Amyotrophic lateral sclerosis/motor neuron disease	Neurodegenerative disorders	Neurology and neurodevelopmental disorders	Other	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1, OMIM:105550				21944778;21944779;25638642;27059391;23597494		False	1	0;0;100	1.74	False	Other - please provide details in the comments	ENSG00000147894	ENSG00000147894	HGNC:28337													
CHCHD10	gene	CHCHD10	Expert Review Red;Radboud University Medical Center, Nijmegen	Amyotrophic lateral sclerosis/motor neuron disease	Neurodegenerative disorders	Neurology and neurodevelopmental disorders		?Myopathy, isolated mitochondrial, autosomal dominant, 616209						False	1	0;0;0	1.74	False		ENSG00000250479	ENSG00000250479	HGNC:15559													
CHMP2B	gene	CHMP2B	Expert Review Red;Radboud University Medical Center, Nijmegen	Amyotrophic lateral sclerosis/motor neuron disease	Neurodegenerative disorders	Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Dementia, familial, nonspecific, 600795;Amyotrophic lateral sclerosis 17, 614696				"PMID: 20352044 - ""We conclude that in a population drawn from North of England pathogenic CHMP2B mutations are found in approximately 1% of cases of ALS and 10% of those with lower motor neuron predominant ALS. We provide a body of evidence indicating the likely pathogenicity of the reported gene alterations. However, absolute confirmation of pathogenicity requires further evidence, including documentation of familial transmission in ALS pedigrees which might be most fruitfully explored in cases with a LMN predominant phenotype."""		False	1	0;0;100	1.74	False	Other - please provide details in the comments	ENSG00000083937	ENSG00000083937	HGNC:24537													
ERBB4	gene	ERBB4	Expert Review Red;Radboud University Medical Center, Nijmegen	Amyotrophic lateral sclerosis/motor neuron disease	Neurodegenerative disorders	Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Amyotrophic lateral sclerosis 19, 615515						False	1	0;0;100	1.74	False		ENSG00000178568	ENSG00000178568	HGNC:3432													
GRN	gene	GRN	Expert;Expert Review Red	Amyotrophic lateral sclerosis/motor neuron disease	Neurodegenerative disorders	Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown							False	1	0;0;0	1.74	False		ENSG00000030582	ENSG00000030582	HGNC:4601													
HFE	gene	HFE	Literature	Amyotrophic lateral sclerosis/motor neuron disease	Neurodegenerative disorders	Neurology and neurodevelopmental disorders	Unknown							False	1	0;0;0	1.74	False		ENSG00000010704	ENSG00000010704	HGNC:4886													
SLC52A1	gene	SLC52A1	Expert list;Expert Review Red	Amyotrophic lateral sclerosis/motor neuron disease	Neurodegenerative disorders	Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Riboflavin deficiency (condition resembling childhood-onset motor neurone disease)						False	1	0;0;0	1.74	False		ENSG00000132517	ENSG00000132517	HGNC:30225													
UNC13A	gene	UNC13A	Literature	Amyotrophic lateral sclerosis/motor neuron disease	Neurodegenerative disorders	Neurology and neurodevelopmental disorders	Unknown					35197628		False	1	0;100;0	1.74	False		ENSG00000130477	ENSG00000130477	HGNC:23150													
VEGFA	gene	VEGFA	Literature	Amyotrophic lateral sclerosis/motor neuron disease	Neurodegenerative disorders	Neurology and neurodevelopmental disorders	Unknown							False	1	0;0;0	1.74	False		ENSG00000112715	ENSG00000112715	HGNC:12680