Entity Name	Entity type	Gene Symbol	Sources(; separated)	Level4	Level3	Level2	Model_Of_Inheritance	Phenotypes	Omim	Orphanet	HPO	Publications	Description	Flagged	GEL_Status	UserRatings_Green_amber_red	version	ready	Mode of pathogenicity	EnsemblId(GRch37)	EnsemblId(GRch38)	HGNC	Position Chromosome	Position GRCh37 Start	Position GRCh37 End	Position GRCh38 Start	Position GRCh38 End	STR Repeated Sequence	STR Normal Repeats	STR Pathogenic Repeats	Region Haploinsufficiency Score	Region Triplosensitivity Score	Region Required Overlap Percentage	Region Variant Type	Region Verbose Name
ATN1	gene	ATN1	Expert Review Red;Other	Early onset dementia (encompassing fronto-temporal dementia and prion disease)	Neurodegenerative disorders	Neurology and neurodevelopmental disorders	Other	Dentatorubral-pallidoluysian atrophy, OMIM:125370						False	1	0;0;100	1.84	True	Other - please provide details in the comments	ENSG00000111676	ENSG00000111676	HGNC:3033													
C9orf72	gene	C9orf72	Eligibility statement prior genetic testing;Expert Review Red; Illumina TruGenome Clinical Sequencing Services;Illumina TruGenome Clinical Sequencing Services;Radboud University Medical Center, Nijmegen;UKGTN; UKGTN	Early onset dementia (encompassing fronto-temporal dementia and prion disease)	Neurodegenerative disorders	Neurology and neurodevelopmental disorders	Other	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1, OMIM:105550						False	1	100;0;0	1.84	True	Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments	ENSG00000147894	ENSG00000147894	HGNC:28337													
CHCHD10	gene	CHCHD10	Expert Review Red;Radboud University Medical Center, Nijmegen	Early onset dementia (encompassing fronto-temporal dementia and prion disease)	Neurodegenerative disorders	Neurology and neurodevelopmental disorders		?Myopathy, isolated mitochondrial, autosomal dominant, 616209						False	1	0;0;100	1.84	True		ENSG00000250479	ENSG00000250479	HGNC:15559													
DCTN1	gene	DCTN1	Other	Early onset dementia (encompassing fronto-temporal dementia and prion disease)	Neurodegenerative disorders	Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Perry syndrome						False	1	0;100;0	1.84	False		ENSG00000204843	ENSG00000204843	HGNC:2711													
FUS	gene	FUS	Expert Review Red;UKGTN	Early onset dementia (encompassing fronto-temporal dementia and prion disease)	Neurodegenerative disorders	Neurology and neurodevelopmental disorders		Dementia 						False	1	100;0;0	1.84	False		ENSG00000089280	ENSG00000089280	HGNC:4010													
GBA	gene	GBA	Radboud University Medical Center, Nijmegen	Early onset dementia (encompassing fronto-temporal dementia and prion disease)	Neurodegenerative disorders	Neurology and neurodevelopmental disorders		Gaucher disease, type I, 230800						False	1	0;100;0	1.84	False		ENSG00000177628	ENSG00000177628	HGNC:4177													
HNRNPA1	gene	HNRNPA1	Radboud University Medical Center, Nijmegen	Early onset dementia (encompassing fronto-temporal dementia and prion disease)	Neurodegenerative disorders	Neurology and neurodevelopmental disorders		?Inclusion body myopathy wtih early-onset Paget disease without frontotemporal						False	1	0;100;0	1.84	False		ENSG00000135486	ENSG00000135486	HGNC:5031													
HTRA1	gene	HTRA1	UKGTN	Early onset dementia (encompassing fronto-temporal dementia and prion disease)	Neurodegenerative disorders	Neurology and neurodevelopmental disorders		Dementia 						False	1	0;0;100	1.84	False		ENSG00000166033	ENSG00000166033	HGNC:9476													
JPH3	gene	JPH3	Expert Review	Early onset dementia (encompassing fronto-temporal dementia and prion disease)	Neurodegenerative disorders	Neurology and neurodevelopmental disorders	Other	Huntington disease-like 2, OMIM:606438						False	1	0;0;100	1.84	False	Other - please provide details in the comments	ENSG00000154118	ENSG00000154118	HGNC:14203													
SNCA	gene	SNCA	Expert Review Red;Radboud University Medical Center, Nijmegen	Early onset dementia (encompassing fronto-temporal dementia and prion disease)	Neurodegenerative disorders	Neurology and neurodevelopmental disorders		Parkinson disease 4, 605543						False	1	100;0;0	1.84	False		ENSG00000145335	ENSG00000145335	HGNC:11138													
SNCB	gene	SNCB	Radboud University Medical Center, Nijmegen	Early onset dementia (encompassing fronto-temporal dementia and prion disease)	Neurodegenerative disorders	Neurology and neurodevelopmental disorders		Dementia, Lewy body, 127750						False	1	0;50;50	1.84	False		ENSG00000074317	ENSG00000074317	HGNC:11140													
TREM2	gene	TREM2	UKGTN	Early onset dementia (encompassing fronto-temporal dementia and prion disease)	Neurodegenerative disorders	Neurology and neurodevelopmental disorders		Dementia 						False	1	0;0;100	1.84	False		ENSG00000095970	ENSG00000095970	HGNC:17761