Entity Name	Entity type	Gene Symbol	Sources(; separated)	Level4	Level3	Level2	Model_Of_Inheritance	Phenotypes	Omim	Orphanet	HPO	Publications	Description	Flagged	GEL_Status	UserRatings_Green_amber_red	version	ready	Mode of pathogenicity	EnsemblId(GRch37)	EnsemblId(GRch38)	HGNC	Position Chromosome	Position GRCh37 Start	Position GRCh37 End	Position GRCh38 Start	Position GRCh38 End	STR Repeated Sequence	STR Normal Repeats	STR Pathogenic Repeats	Region Haploinsufficiency Score	Region Triplosensitivity Score	Region Required Overlap Percentage	Region Variant Type	Region Verbose Name
BRCA2	gene	BRCA2	Expert list;Expert Review Green	Familial prostate cancer			MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	{Prostate cancer}, OMIM:176807				26360800;10398279 - no association found with breast/ovarian cance susceptibility variants;26289772;26236408 - literature review indicating there is conflicting reports;26074382;21952622;28031937		False	3	100;0;0	1.4	False		ENSG00000139618	ENSG00000139618	HGNC:1101													
BRCA1	gene	BRCA1	Expert list;Expert Review Amber	Familial prostate cancer			MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Prostate cancer, MONDO:0008315				27989354;27899188;27742670;27433846;27317574;27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001);27188668;26926928;26360800 - no increased risk;26236408 - literature review indicating there is conflicting reports;22516946;28031937		False	2	100;0;0	1.4	False		ENSG00000012048	ENSG00000012048	HGNC:1100													
BRIP1	gene	BRIP1	Literature	Familial prostate cancer			Unknown					26074382		False	1	0;0;0	1.4	False		ENSG00000136492	ENSG00000136492	HGNC:20473													
CHEK2	gene	CHEK2	Literature	Familial prostate cancer			MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	{Prostate cancer, familial, susceptibility to}				26074382		False	1	0;0;0	1.4	False		ENSG00000183765	ENSG00000183765	HGNC:16627													
ELAC2	gene	ELAC2	Literature	Familial prostate cancer			Unknown	hereditary prostate cancer				28031937		False	1	0;0;0	1.4	False		ENSG00000006744	ENSG00000006744	HGNC:14198													
HOXB13	gene	HOXB13	Literature	Familial prostate cancer			Unknown					26074382;28031937		False	1	0;0;0	1.4	False		ENSG00000159184	ENSG00000159184	HGNC:5112													
MSH2	gene	MSH2	Expert list	Familial prostate cancer			Unknown					26289772		False	1	0;0;100	1.4	False		ENSG00000095002	ENSG00000095002	HGNC:7325													
MSH5	gene	MSH5	Literature	Familial prostate cancer			Unknown	prostate cancer susceptibility				26964030		False	1	0;0;0	1.4	False		ENSG00000204410	ENSG00000204410	HGNC:7328													
MSH6	gene	MSH6	Literature	Familial prostate cancer			Unknown					27456091		False	1	0;0;0	1.4	False		ENSG00000116062	ENSG00000116062	HGNC:7329													
MSR1	gene	MSR1	Other	Familial prostate cancer			MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Prostate cancer, hereditary				12244320;12244320;12958598 - found no association and the variant reported in PMID:12244320 has been reclassified;27084275;26225686 - no association with another variant found in meta-analysis;28031937		False	1	0;0;0	1.4	False		ENSG00000038945	ENSG00000038945	HGNC:7376													
PALB2	gene	PALB2	Literature	Familial prostate cancer			Unknown					26074382		False	1	0;0;0	1.4	False		ENSG00000083093	ENSG00000083093	HGNC:26144													
PTEN	gene	PTEN	Other	Familial prostate cancer			BIALLELIC, autosomal or pseudoautosomal	harmartoma, glioma, prostate, endometrial;Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome						False	1	0;0;0	1.4	False		ENSG00000171862	ENSG00000171862	HGNC:9588													
RNASEL	gene	RNASEL	Literature	Familial prostate cancer			Unknown	hereditary prostate cancer				28031937		False	1	0;0;0	1.4	False		ENSG00000135828	ENSG00000135828	HGNC:10050													
SPOP	gene	SPOP	Other	Familial prostate cancer			BIALLELIC, autosomal or pseudoautosomal	prostate cancer						False	1	0;0;0	1.4	False		ENSG00000121067	ENSG00000121067	HGNC:11254