Entity Name	Entity type	Gene Symbol	Sources(; separated)	Level4	Level3	Level2	Model_Of_Inheritance	Phenotypes	Omim	Orphanet	HPO	Publications	Description	Flagged	GEL_Status	UserRatings_Green_amber_red	version	ready	Mode of pathogenicity	EnsemblId(GRch37)	EnsemblId(GRch38)	HGNC	Position Chromosome	Position GRCh37 Start	Position GRCh37 End	Position GRCh38 Start	Position GRCh38 End	STR Repeated Sequence	STR Normal Repeats	STR Pathogenic Repeats	Region Haploinsufficiency Score	Region Triplosensitivity Score	Region Required Overlap Percentage	Region Variant Type	Region Verbose Name
APOA1	gene	APOA1	Expert Review Green;NHS GMS	Hereditary systemic amyloidosis		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Amyloidosis, 3 or more types OMIM:105200;familial visceral amyloidosis MONDO:0007099				27240838;21820994;16925563;32022753		False	3	100;0;0	1.28	False		ENSG00000118137	ENSG00000118137	HGNC:600													
APOA2	gene	APOA2	Expert Review Green;NHS GMS	Hereditary systemic amyloidosis		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted					29270531;11703582;12787390;11401442		False	3	100;0;0	1.28	False		ENSG00000158874	ENSG00000158874	HGNC:601													
APOC2	gene	APOC2	Expert Review Green;NHS GMS	Hereditary systemic amyloidosis		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted					30197986;27297947		False	3	100;0;0	1.28	False		ENSG00000234906	ENSG00000234906	HGNC:609													
FGA	gene	FGA	Expert Review Green;NHS GMS	Hereditary systemic amyloidosis		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Amyloidosis, familial visceral, OMIM:105200				19073821;29142973;23551149		False	3	100;0;0	1.28	False		ENSG00000171560	ENSG00000171560	HGNC:3661													
GSN	gene	GSN	Expert Review Green;NHS GMS	Hereditary systemic amyloidosis		Renal	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Amyloidosis, Finnish type, OMIM:105120				24601799;25342098;22938848		False	3	100;0;0	1.28	False		ENSG00000148180	ENSG00000148180	HGNC:4620													
LYZ	gene	LYZ	Expert Review Green;NHS GMS	Hereditary systemic amyloidosis		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Amyloidosis, renal 105200				21988333		False	3	100;0;0	1.28	False		ENSG00000090382	ENSG00000090382	HGNC:6740													
TTR	gene	TTR	Expert Review Green;NHS GMS	Hereditary systemic amyloidosis		Renal	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Amyloidosis, hereditary, transthyretin-related 105210				30328212;14640030;30878017;31131842;31118583;31111153;30120737		False	3	100;0;0	1.28	False		ENSG00000118271	ENSG00000118271	HGNC:12405													
APOA4	gene	APOA4	Expert Review Amber;Literature	Hereditary systemic amyloidosis		Renal	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Tubulointerstitial kidney disease, autosomal dominant 6, OMIM: 621106;tubulointerstitial kidney disease, autosomal dominant 6, MONDO:0976234;AApoAIV amyloidosis, MONDO:0018589				21900878;27262366;33751222;38096951;39699959		False	2	100;0;0	1.28	False		ENSG00000110244	ENSG00000110244	HGNC:602													
APOC3	gene	APOC3	Expert Review Amber;NHS GMS	Hereditary systemic amyloidosis		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted					26790392		False	2	100;0;0	1.28	False		ENSG00000110245	ENSG00000110245	HGNC:610													
B2M	gene	B2M	Expert Review Amber;NHS GMS	Hereditary systemic amyloidosis		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	?Amyloidosis, familial visceral 105200				22693999		False	2	100;0;0	1.28	False		ENSG00000166710	ENSG00000166710	HGNC:914													
CST3	gene	CST3	Expert Review Amber;NHS GMS	Hereditary systemic amyloidosis		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Cerebral amyloid angiopathy 105150				2900981;3495457;1352269;3673496;7482672		False	2	100;0;0	1.28	False		ENSG00000101439	ENSG00000101439	HGNC:2475													
NLRP3	gene	NLRP3	Expert list;Expert Review Amber	Hereditary systemic amyloidosis		Renal	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Muckle-Wells syndrome, OMIM:191900;Renal amyloidosis				11687797;28229991;27435956;31057541;30431487		False	2	100;0;0	1.28	False		ENSG00000162711	ENSG00000162711	HGNC:16400