Entity Name	Entity type	Gene Symbol	Sources(; separated)	Level4	Level3	Level2	Model_Of_Inheritance	Phenotypes	Omim	Orphanet	HPO	Publications	Description	Flagged	GEL_Status	UserRatings_Green_amber_red	version	ready	Mode of pathogenicity	EnsemblId(GRch37)	EnsemblId(GRch38)	HGNC	Position Chromosome	Position GRCh37 Start	Position GRCh37 End	Position GRCh38 Start	Position GRCh38 End	STR Repeated Sequence	STR Normal Repeats	STR Pathogenic Repeats	Region Haploinsufficiency Score	Region Triplosensitivity Score	Region Required Overlap Percentage	Region Variant Type	Region Verbose Name
C3	gene	C3	Expert list;Expert Review Green;NHS GMS	Membranoproliferative glomerulonephritis including C3 glomerulopathy		Renal	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Hemolytic uremic syndrome, atypical, susceptibility to, 5, OMIM:612925;C3 glomerulopathy;C3G				24172683;20852386;18796626;21902819;26471127		False	3	50;25;25	3.8	False	Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments	ENSG00000125730	ENSG00000125730	HGNC:1318													
CFB	gene	CFB	Expert list;Expert Review Green;NHS GMS	Membranoproliferative glomerulonephritis including C3 glomerulopathy		Renal	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Haemolytic uraemic syndrome;aHUS;Hemolytic uremic syndrome, atypical, susceptibility to, 4, 612924;C3 glomerulopathy;C3G;Immune complex MPGN;IC-MPGN;MPGN;Membranoproliferative glomerulonephritis				25758434;17182750;21902819;26283675		False	3	20;40;40	3.8	False	Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments	ENSG00000243649	ENSG00000243649	HGNC:1037													
CFH	gene	CFH	Expert list;Expert Review Green;NHS GMS	Membranoproliferative glomerulonephritis including C3 glomerulopathy		Renal	BIALLELIC, autosomal or pseudoautosomal	C3 glomerulopathy;C3G; Immune complex MPGN;IC-MPGN;Hemolytic uremic syndrome, atypical, susceptibility to, 1, 235400; Dense Deposit Disease; Membranoproliferative Glomerulonephritis Type II;Immune-complex-mediated MPGN				24172683;16612335;24722444;27458560;9312129		False	3	75;25;0	3.8	False		ENSG00000000971	ENSG00000000971	HGNC:4883													
CFHR1	gene	CFHR1	Expert list;Expert Review Green	Membranoproliferative glomerulonephritis including C3 glomerulopathy		Renal	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	C3 glomerulopathy;C3G; Immune complex MPGN;IC-MPGN; Hemolytic uremic syndrome, atypical, susceptibility to, 235400;Immune-complex-mediated MPGN				24172683;23728178;24334459;20800271;27458560		False	3	100;0;0	3.8	False		ENSG00000244414	ENSG00000244414	HGNC:4888													
CFHR2	gene	CFHR2	Expert list;Expert Review Green	Membranoproliferative glomerulonephritis including C3 glomerulopathy		Renal	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	C3 glomerulopathy;C3G; Immune complex MPGN;IC-MPGN;Immune-complex-mediated MPGN				24172683;24334459;23728178;20800271; 22456601;27458560		False	3	100;0;0	3.8	False		ENSG00000080910	ENSG00000080910	HGNC:4890													
CFHR5	gene	CFHR5	Expert list;Expert Review Green;NHS GMS	Membranoproliferative glomerulonephritis including C3 glomerulopathy		Renal	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	C3 glomerulopathy;C3G;Immune complex MPGN;IC-MPGN;Nephropathy due to CFHR5 deficiency, OMIM:614809;Immune-complex-mediated MPGN;CFHR5 nephropathy;Haematuria;Chronic Kidney Disease;Proteinuria;End stage renal disease				24172683;20800271;24067434;23728178;27458560;21566112;32928961;22503529;30844074;28729035;27490940;28729035;27490940;33753502;30197990		False	3	100;0;0	3.8	False	Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments	ENSG00000134389	ENSG00000134389	HGNC:24668													
CFI	gene	CFI	Expert list;Expert Review Green;NHS GMS	Membranoproliferative glomerulonephritis including C3 glomerulopathy		Renal	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	C3 glomerulopathy; C3G; Immune complex MPGN; IC-MPGN; Immune-complex-mediated MPGN;Hemolytic uremic syndrome, atypical, susceptibility to, 3,612923				24172683;18371543;22456601;27458560		False	3	50;0;50	3.8	False		ENSG00000205403	ENSG00000205403	HGNC:5394													
DGKE	gene	DGKE	Expert list;Expert Review Green;NHS GMS	Membranoproliferative glomerulonephritis including C3 glomerulopathy		Renal	BIALLELIC, autosomal or pseudoautosomal	Haemolytic uraemic syndrome; aHUS; Hemolytic uremic syndrome, atypical, susceptibility to, 7, 615008; Nephrotic syndrome, type 7, 615008;C3 glomerulopathy; C3G; Immune complex MPGN; IC-MPGN				23274426;23542698;21902819;28526779		False	3	33;33;33	3.8	True		ENSG00000153933	ENSG00000153933	HGNC:2852