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| COVID-19 research v0.377 | CD200 | Sarah Leigh Publications for gene: CD200 were set to 19587022 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.376 | CD200 | Sarah Leigh Classified gene: CD200 as Red List (low evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.376 | CD200 |
Sarah Leigh Added comment: Comment on list classification: Not associated with a phenotype in OMIM or in Gen2Phen. However, CD200 is a membrane protein that interacts with CD200R on the surface of immune cells and delivers an inhibitory signal to suppress immune functions as a "check point" to prevent an excessive inflammatory response . Viral homologs of CD200, such as rat cytomegalovirus e127 protein, may play a role in suppressing the host immune response (PMID 19587022). Conversely, in coronavirus infection, inhibition of CD200-CD200R1 results in restoring IFN production and increasing virus clearance (PMID 30032349). Therefore understanding of the mechanisms of CD200-CD200R action may help in development of treatments. |
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| COVID-19 research v0.376 | CD200 | Sarah Leigh Gene: cd200 has been classified as Red List (Low Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.375 | CD200 | Sarah Leigh Publications for gene: CD200 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.374 | CD200 | Sarah Leigh reviewed gene: CD200: Rating: ; Mode of pathogenicity: None; Publications: 19587022; Phenotypes: ; Mode of inheritance: None | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.338 | CD200 |
Sarah Leigh gene: CD200 was added gene: CD200 was added to COVID-19 research. Sources: OMIM Mode of inheritance for gene: CD200 was set to Unknown |
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