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| COVID-19 research v1.66 | TMEM181 |
Arina Puzriakova gene: TMEM181 was added gene: TMEM181 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: TMEM181 was set to Unknown Added comment: Preprint: https://doi.org/10.1101/2020.07.01.20144592 Using UK Biobank data of 5,871 participants tested for COVID-19, including 193 deaths from 1,412 confirmed infections, authors identified 5 risk variants in 4 genes (ERAP2, BRF2, TMEM181, ALOXE3) associated with death from SARS-CoV-2 infection. TMEM181 SNP (rs117665206, R403C). Authors state that this could be a potentially druggable target for treatment with Cysteamine in COVID-19 patients with this variant. However, whether this genetic variant has any physiological role on SARS-CoV-2 infection is yet to be determined. Sources: Literature |
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| COVID-19 research v1.65 | ALOXE3 |
Arina Puzriakova gene: ALOXE3 was added gene: ALOXE3 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: ALOXE3 was set to Unknown Added comment: Preprint: https://doi.org/10.1101/2020.07.01.20144592 Using UK Biobank data of 5,871 participants tested for COVID-19, including 193 deaths from 1,412 confirmed infections, authors identified 5 novel risk variants in 4 genes (ERAP2, BRF2, TMEM181, ALOXE3) associated with death from SARS-CoV-2 infection. Two ALOXE3 SNP (rs147149459, rs151256885) identified. Furthermore, it has been shown that ALOXE3 is upregulated by SARS-CoV in human airway epithelial cultures. However, whether genetic variants have any physiological role on SARS-CoV-2 infection is yet to be determined. Sources: Literature |
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| COVID-19 research v1.64 | ERAP2 |
Arina Puzriakova changed review comment from: Preprint: https://doi.org/10.1101/2020.07.01.20144592 Using UK Biobank data of 5,871 participants tested for COVID-19, including 193 deaths from 1,412 confirmed infections, authors identified 5 risk variants in 4 genes (ERAP2, BRF2, TMEM181, ALOXE3) associated with death from SARS-CoV-2 infection. The ERAP2 SNP (rs150892504, R751C) was disruptive to the fold of the protein, in turn decreasing stability. Authors state that this could be a potentially druggable target for treatment with Cysteamine in COVID-19 patients with this variant. Sources: Literature; to: Preprint: https://doi.org/10.1101/2020.07.01.20144592 Using UK Biobank data of 5,871 participants tested for COVID-19, including 193 deaths from 1,412 confirmed infections, authors identified 5 risk variants in 4 genes (ERAP2, BRF2, TMEM181, ALOXE3) associated with death from SARS-CoV-2 infection. The ERAP2 SNP (rs150892504, R751C) was disruptive to the fold of the protein, in turn decreasing stability. Authors state that this could be a potentially druggable target for treatment with Cysteamine in COVID-19 patients with this variant. However, whether this genetic variant has any physiological role on SARS-CoV-2 infection is yet to be determined. Sources: Literature |
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| COVID-19 research v1.64 | BRF2 |
Arina Puzriakova gene: BRF2 was added gene: BRF2 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: BRF2 was set to Unknown Added comment: Preprint: https://doi.org/10.1101/2020.07.01.20144592 Using UK Biobank data of 5,871 participants tested for COVID-19, including 193 deaths from 1,412 confirmed infections, authors identified 5 novel risk variants in 4 genes (ERAP2, BRF2, TMEM181, ALOXE3) associated with death from SARS-CoV-2 infection. Structural analysis showed the BRF2 SNP (rs138763430, D9N) at the Zn Ribbon domain alters the electrostatic potential surface, which in turn impacts the fundamental property of the domain to recognise nucleotide binding partners. Thus authors speculate that this variant most likely negatively alters the selectivity of the protein. However, whether this genetic variant has any physiological role on SARS-CoV-2 infection is yet to be determined. Sources: Literature |
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| COVID-19 research v1.63 | ERAP2 |
Arina Puzriakova gene: ERAP2 was added gene: ERAP2 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: ERAP2 was set to Unknown Added comment: Preprint: https://doi.org/10.1101/2020.07.01.20144592 Using UK Biobank data of 5,871 participants tested for COVID-19, including 193 deaths from 1,412 confirmed infections, authors identified 5 risk variants in 4 genes (ERAP2, BRF2, TMEM181, ALOXE3) associated with death from SARS-CoV-2 infection. The ERAP2 SNP (rs150892504, R751C) was disruptive to the fold of the protein, in turn decreasing stability. Authors state that this could be a potentially druggable target for treatment with Cysteamine in COVID-19 patients with this variant. Sources: Literature |
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