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| COVID-19 research v0.302 | TMPRSS11A |
Eleanor Williams gene: TMPRSS11A was added gene: TMPRSS11A was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: TMPRSS11A was set to Unknown Publications for gene: TMPRSS11A were set to https://doi.org/10.1101/2020.05.13.093690 Review for gene: TMPRSS11A was set to RED Added comment: Preprint: Klaassen et al https://doi.org/10.1101/2020.05.13.093690 - performed analysis of variants in FURIN, PLG, PRSS1, TMPRSS11a, MBL2 and OAS1 genes in 143 unrelated individuals from Serbian population and identified 22 variants with potential functional effect. Then used in-silico prediction and comparative population analysis and found 2 rare variants p.Lys48Arg and p.Arg328Gln. For both of these variants, PolyPhen-2, SIFT and MutPred2 algorithms predict benign/tolerated effect but the protein structure of TMPRSS11a is not well known. Sources: Literature |
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| COVID-19 research v0.301 | PRSS1 |
Eleanor Williams gene: PRSS1 was added gene: PRSS1 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: PRSS1 was set to Unknown Publications for gene: PRSS1 were set to https://doi.org/10.1101/2020.05.13.093690 Added comment: Preprint: Klaassen et al https://doi.org/10.1101/2020.05.13.093690 - performed analysis of variants in FURIN, PLG, PRSS1, TMPRSS11a, MBL2 and OAS1 genes in 143 unrelated individuals from Serbian population and identified 22 variants with potential functional effect. Then used in-silico prediction and comparative population analysis and found two rare variants in the PRSS1 gene, c.592-8C>T and p.Asn54Lys. Variant c.592-8C>T was previously detected in patients with cystic fibrosis presenting with chronic pancreatitis and p.Asn54Lys is predicted to be possibly damaging. Sources: Literature |
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| COVID-19 research v0.300 | PLG |
Eleanor Williams gene: PLG was added gene: PLG was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: PLG was set to Unknown Publications for gene: PLG were set to https://doi.org/10.1101/2020.05.13.093690 Review for gene: PLG was set to RED Added comment: Preprint: Klaassen et al https://doi.org/10.1101/2020.05.13.093690 - performed analysis of variants in FURIN, PLG, PRSS1, TMPRSS11a, MBL2 and OAS1 genes in 143 unrelated individuals from Serbian population and identified 22 variants with potential functional effect. Then used in-silico prediction and comparative population analysis and found 6 rare variants in PLG. p.Arg261His and p.Ala494Val are predicted to be probably damaging/deleterious. Sources: Literature |
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| COVID-19 research v0.299 | FURIN |
Eleanor Williams commented on gene: FURIN: Preprint: Klaassen et al https://doi.org/10.1101/2020.05.13.093690 - performed analysis of variants in FURIN, PLG, PRSS1, TMPRSS11a, MBL2 and OAS1 genes in 143 unrelated individuals from Serbian population and identified 22 variants with potential functional effect. Then used in-silico prediction and comparative population analysis and found two rare variants in FURIN p.Thr33Ala and p.Gly146Ser. p.Gly146Ser. is predicted to be deleterious and may change its ability to cleave furin-like sites in the S protein of the SARS-CoV-2. |
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| COVID-19 research v0.211 | FURIN | Rebecca Foulger Publications for gene: FURIN were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.210 | FURIN | Rebecca Foulger Classified gene: FURIN as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.210 | FURIN | Rebecca Foulger Added comment: Comment on list classification: Updated rating from Red to Amber: Although no SNP studies, or potential variants identified yet, recent papers (e.g. PMID:32362314) and preprints have identified a role for Furin protease activity in SARS-CoV-2 entry into human cells. Therefore changes to Furin sequence could potentially alter viral susceptibility. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.210 | FURIN | Rebecca Foulger Gene: furin has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.209 | FURIN | Rebecca Foulger commented on gene: FURIN: PMID:32362314. Hoffmann et al., 2020 report that Furin cleaves the SARS-CoV-2 spike protein at the S1/S2 site, and that cleavage is essential for S-protein-mediated cell-cell fusion and entry into human lung cells. Therefore furin may be a potential target for therapuetic intervention. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.209 | FURIN | Rebecca Foulger commented on gene: FURIN: PMID:25974265. Hardes et al., 2015. Furing is required for H7N1 and H5N1 influenza virus infection, probably by cleaving hemagglutinin. Therefore inhibition of Furin is a potential strategy for short-term treatment of acute infectious diseases, including avian influenza. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.209 | FURIN | Rebecca Foulger commented on gene: FURIN | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.141 | FURIN |
Eleanor Williams gene: FURIN was added gene: FURIN was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: FURIN was set to Unknown Added comment: Preprint - https://doi.org/10.1101/2020.04.18.047951- Zhong et al Found Furin is expressed in oral mucosal cells. A Furin cutting site has been identified in SARS-CoV-2 (https://doi.org/10.1101/2020.02.10.942185 - preprint) Sources: Literature |
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