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| COVID-19 research v0.196 | IL6ST | Sarah Leigh Publications for gene: IL6ST were set to 31235509; 32086639; 30309848; 28747427; 32048120 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.171 | IL6ST | Sophie Hambleton reviewed gene: IL6ST: Rating: GREEN; Mode of pathogenicity: None; Publications: 31914175, 32207811; Phenotypes: recurrent infections, eczema, bronchiectasis, high IgE, eosinophilia, defective B cell memory, impaired acute-phase response, stuve-wiedemann syndrome, craniosynostosis; Mode of inheritance: BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.40 | IL6ST |
Ellen McDonagh Source Expert Review Green was added to IL6ST. Added phenotypes Eczema; Abnormal acute-phase responses; Recurrent infections; Bacterial infections, boiles, eczema, pulmonary abscesses, pneumatoceles, bone fractures, scoliosis, retention of primary teeth, craniosynostosis; Eosinophilia; Elevated IgE; Combined immunodeficiencies with associated or syndromic features for gene: IL6ST Rating Changed from Red List (low evidence) to Green List (high evidence) |
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| COVID-19 research v0.36 | IL6ST |
Ellen McDonagh gene: IL6ST was added gene: IL6ST was added to Viral susceptibility. Sources: Expert Review Red,Literature,IUIS Classification December 2019 Mode of inheritance for gene: IL6ST was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: IL6ST were set to 31235509; 32086639; 30309848; 28747427; 32048120 Phenotypes for gene: IL6ST were set to Eczema; Abnormal acute-phase responses; Recurrent infections; Bacterial infections, boiles, eczema, pulmonary abscesses, pneumatoceles, bone fractures, scoliosis, retention of primary teeth, craniosynostosis; Eosinophilia; Elevated IgE; Combined immunodeficiencies with associated or syndromic features |
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