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| COVID-19 research v0.374 | IRF5 | Rebecca Foulger Classified gene: IRF5 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.374 | IRF5 | Rebecca Foulger Added comment: Comment on list classification: Green rating suggested after initial triage by Illumina curation team. Kept rating as Green following literature review: PMID:29375210 demonstrate that polymorphisms in IRF5 can affect viral disease progression. Functional studies and animal models (fish and mice) show that IRF5 is required for antiviral immunity. Therefore on balance, kept rating as Green. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.374 | IRF5 | Rebecca Foulger Gene: irf5 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.373 | IRF5 |
Rebecca Foulger commented on gene: IRF5: PMID:30457675. Chow et al., 2019 examined IRF5-dependent gene expression and found that loss of IRF5 in mice resulted in modest and subtle changes in the expression of West Nile Virus (WNV)-regulated genes. 15320958 |
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| COVID-19 research v0.373 | IRF5 | Rebecca Foulger commented on gene: IRF5: PMID:21240265. Krausgruber et al., 2011 state that polymorphisms in IRF5 that lead to higher mRNA expression are associated with many autoimmune diseases. Global gene expression analysis demonstrated that exogenous IRF5 upregulated or downregulated expression of established phenotypic markers of M1 or M2 macrophages, respectively, defining a role for IRF5 as a transcriptional repressor. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.373 | IRF5 | Rebecca Foulger commented on gene: IRF5: PMID:29079574. Cevik et al., 2017 identify IRF5 as an important suppressor of HCV replication and HCC pathogenesis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.373 | IRF5 | Rebecca Foulger commented on gene: IRF5: PMID:29375210. Sy et al., 2018 investigated possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibility to hepatitis B virus (HBV) infection and liver disease outcomes. Comparing patients and controls, no significant association was observed in viral load for the four IFR5 variants studied, but alleles rs13242262T and rs10488630G contributed to an increased risk of liver cirrhosis. The process of liver cirrhosis in HBV infection is a results of the interplay between viral factors and host immune responses suggesting that IRF5 haplotypes appear to influence the outcome of HBV infection. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.373 | IRF5 | Rebecca Foulger commented on gene: IRF5: PMID:32075938. Forbester et al., 2020 use human-induced pluripotent stem cells (hIPSCs) with biallelic mutations in IRF5, and showed that IRF5 deficiency corresponded with reduced influenza virus-induced inflammatory cytokine production. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.373 | IRF5 | Rebecca Foulger commented on gene: IRF5: PMID:17360658. Yanai et al., 2007. Mouse model: authors show that IRF5 is critical for antiviral immunity by showing that Irf5(-/-) mice are highly vulnerable to viral infections. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.373 | IRF5 | Rebecca Foulger Publications for gene: IRF5 were set to 17360658; 32075938; 29375210; 29079574; 1240265; 30457675 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.372 | IRF5 | Rebecca Foulger Publications for gene: IRF5 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.353 | IRF5 | Rebecca Foulger Classified gene: IRF5 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.353 | IRF5 | Rebecca Foulger Gene: irf5 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.352 | IRF5 | Rebecca Foulger commented on gene: IRF5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.352 | IRF5 |
Rebecca Foulger gene: IRF5 was added gene: IRF5 was added to COVID-19 research. Sources: Expert list Mode of inheritance for gene: IRF5 was set to Unknown |
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