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| COVID-19 research v0.325 | SLAMF6 |
Catherine Snow gene: SLAMF6 was added gene: SLAMF6 was added to COVID-19 research. Sources: Expert list Mode of inheritance for gene: SLAMF6 was set to Unknown Publications for gene: SLAMF6 were set to 30366106 Added comment: Curation by Illumina clinical curators contributing to Covid-19 effort. Curation on all OMIM genes which hit the term "virus". Currently no gene disease association for SLAMF6. Natural cytotoxicity receptors, such as NKp46, NKp44, and NKp30 (NCR3), are selectively expressed on NK cells and cooperate in the induction of NK cell activity Yigit et al (2019) summarised research in "SLAMF6 in health and disease: Implications for therapeutic targeting" Sources: Expert list |
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| COVID-19 research v0.292 | NCR3 |
Eleanor Williams gene: NCR3 was added gene: NCR3 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: NCR3 was set to Unknown Publications for gene: NCR3 were set to 26094914; 24845613; 30325780 Phenotypes for gene: NCR3 were set to {Malaria, mild, susceptibility to}, 609148 Review for gene: NCR3 was set to RED Added comment: Associated with {Malaria, mild, susceptibility to} #609148 in OMIM. It is also known as NKp30. Evidence that level of NCR3/NKp30 expression is reduced in those infected with virus, and increased in those who remain uninfected. No reports that SNVs in the NCR3 gene affect suceptibility to viral infection. PMID: 26094914 - Mantovani et al 2015 - six different splice variants of the NKp30-encoding gene NCR3, which are known to be expressed on the cell surface. NKp30 receptor expression on NK cells and all isoforms were reduced in chronic hepatitis C virus(HCV)-infected patients. PMID: 24845613 - Sugden et al 2014 - enhanced expression of NKp30 on NK cells resulted in protection from developing HCV infection in multiply exposed uninfected individuals PMID: 30325780 - Lucar et al 2019 - report in HIV-2 patients a very significant reduced expression of the activating NKp30 receptor on NK cells. Sources: Literature |
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