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COVID-19 research v0.294 | OCLN |
Eleanor Williams gene: OCLN was added gene: OCLN was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: OCLN was set to Unknown Publications for gene: OCLN were set to 19182773; 31328852 Review for gene: OCLN was set to RED Added comment: Not associated with any viral susceptibility phenotypes in OMIM. Evidence that OCLN is involved in HCV cell entry PMID: 19182773 - Ploss et al 2009 - show that human occludin is an essential HCV cell entry factor that is able to render murine cells infectable with HCVpp. Similarly, OCLN is required for the HCV-susceptibility of human cells, because its overexpression in uninfectable cells specifically enhanced HCVpp uptake, whereas its silencing in permissive cells impaired both HCVpp and HCVcc infection. PMID: 31328852 - Lavie et al 2019 - looked at which residues in OCLN affect hepatitis C virus (HCV) entry. In the context of full-length OCLN, mutation of I279 and W281 residues only partially affected infection and cell surface localization. Sources: Literature |