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| COVID-19 research v0.207 | SELPLG |
Sarah Leigh commented on gene: SELPLG: PMID: 30833724 identifies SELPLG (refered to as PSGL1 in the literature) as an HIV restriction factor, SELPLG is induced by interferon-γ in activated CD4+ T cells to inhibit HIV-1 reverse transcription and potently block viral infectivity by incorporating in progeny virions. Preprint https://doi.org/10.1101/2020.05.01.073387 report that virion incorporation of SELPLG on SARS-CoV and SARS-CoV-2 pseudovirions blocks S protein-mediated virus attachment and infection of target cells, Suggesting that SELPLG-imprinted non-infectious viral particles could serve as a live attenuated vaccine for SARS-CoV-2 infection. |
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| COVID-19 research v0.207 | SELPLG |
Sarah Leigh gene: SELPLG was added gene: SELPLG was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: SELPLG was set to Unknown Publications for gene: SELPLG were set to 19543284; 30833724; doi.org/10.1101/2020.05.01.073387 Review for gene: SELPLG was set to RED Added comment: In PMID 19543284 SELPLG (refered to as PSGL1 in the literature) is a receptor for 5 of 8 the Enterovirus-71 (EV71) strains. EV71 interaction and viral replication could be inhibited by monoclonal antibodies to SELPLG. The authors concluded that SELPLG-positive leukocytes are involved in the cell tropism and pathogenesis of hand, foot and mouth disease and other EV71-mediated diseases. Sources: Literature |
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