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Primary ovarian insufficiency v1.60 SYCE1 Ivone Leong Classified gene: SYCE1 as Green List (high evidence)
Primary ovarian insufficiency v1.60 SYCE1 Ivone Leong Added comment: Comment on list classification: This gene is associated with a phenotype in OMIM but not in Gene2Phenotype. There is enough evidence to support a gene-disease association (2 cases + 1 animal model). Therefore, this gene has been promoted from Amber to Green.
Primary ovarian insufficiency v1.60 SYCE1 Ivone Leong Gene: syce1 has been classified as Green List (High Evidence).
Primary ovarian insufficiency v1.59 SYCE1 Ivone Leong Added comment: Comment on publications: PMID: 32917591. Authors made knockin mice with the mouse equivalent variant as Q241X seen in PMID:25062452. Both male and female homozygous mutant mice were infertile and replicated the human phenotype.

PMID:34718620. An additional case. Patient is compound heterozygous for variants in SYCE1.
Primary ovarian insufficiency v1.59 SYCE1 Ivone Leong Publications for gene: SYCE1 were set to 25062452
Primary ovarian insufficiency v1.58 SYCE1 Ivone Leong Phenotypes for gene: SYCE1 were changed from Premature ovarian failure 12616947 to ?Premature ovarian failure 12, OMIM:616947
Primary ovarian insufficiency v1.55 SYCE1 Andrey Gagunashvili reviewed gene: SYCE1: Rating: ; Mode of pathogenicity: None; Publications: 34718620; Phenotypes: Premature ovarian failure; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Primary ovarian insufficiency SYCE1 Arianna Tucci marked SYCE1 as ready
Primary ovarian insufficiency SYCE1 Arianna Tucci marked SYCE1 as ready
Primary ovarian insufficiency SYCE1 Arianna Tucci commented on SYCE1
Primary ovarian insufficiency SYCE1 Arianna Tucci classified SYCE1 as amber