| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Severe microcephaly v2.293 | WDR11 | Eleanor Williams Tag Q4_21_rating was removed from gene: WDR11. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Severe microcephaly v2.292 | WDR11 | Sarah Leigh commented on gene: WDR11 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Severe microcephaly v2.291 | WDR11 |
Eleanor Williams Source Expert Review Green was added to WDR11. Rating Changed from Amber List (moderate evidence) to Green List (high evidence) |
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| Severe microcephaly v2.258 | WDR11 |
Ivone Leong changed review comment from: Comment on list classification: Promoted from Red to Amber. This gene is associated with a relevant phenotype in Gene2Phenotype (probable) but not in OMIM. There is enough evidence to support a gene-disease association; however, the severity of ID in the patients described in PMID:34413497 does not fit the criteria for this panel (panel is for moderate to severe ID, patients have mild ID). Therefore, this gene has been given an Amber rating. The OFC of patients in PMID: 34413497 ranged from -3.09 SD to -4.93 SD); to: Comment on list classification: Promoted from Red to Amber. This gene is associated with a relevant phenotype in Gene2Phenotype (probable) but not in OMIM. The OFC of patients in PMID: 34413497 ranged from -3.09 SD to -4.93 SD). There is enough evidence to support a gene-disease association, this gene should be rated Green at the next review. |
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| Severe microcephaly v2.258 | WDR11 |
Ivone Leong Tag watchlist was removed from gene: WDR11. Tag Q4_21_rating tag was added to gene: WDR11. |
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| Severe microcephaly v2.258 | WDR11 | Ivone Leong Entity copied from Intellectual disability v3.1348 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Severe microcephaly v2.258 | WDR11 |
Ivone Leong gene: WDR11 was added gene: WDR11 was added to Severe microcephaly. Sources: Expert Review Amber watchlist tags were added to gene: WDR11. Mode of inheritance for gene: WDR11 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: WDR11 were set to 26350204; 34413497 Phenotypes for gene: WDR11 were set to Intellectual disability, MONDO:0001071; Microcephaly, MONDO:0001149; Short stature,HP:0004322 Penetrance for gene: WDR11 were set to Complete |
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