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Intellectual disability - microarray and sequencing v5.509 WNK3 Arina Puzriakova Phenotypes for gene: WNK3 were changed from X-linked intellectual disability, MONDO:0100284 to Prieto syndrome, OMIM:309610; Intellectual disability, MONDO:0001071
Intellectual disability - microarray and sequencing v5.508 WNK3 Arina Puzriakova Tag gene-checked was removed from gene: WNK3.
Intellectual disability - microarray and sequencing v4.61 WNK3 Achchuthan Shanmugasundram Tag gene-checked tag was added to gene: WNK3.
Intellectual disability - microarray and sequencing v4.53 WNK3 Arina Puzriakova Tag Q3_22_rating was removed from gene: WNK3.
Intellectual disability - microarray and sequencing v4.53 WNK3 Arina Puzriakova commented on gene: WNK3: The rating of this gene has been updated to Green following NHS Genomic Medicine Service approval.
Intellectual disability - microarray and sequencing v4.52 WNK3 Arina Puzriakova Source NHS GMS was added to WNK3.
Source Expert Review Green was added to WNK3.
Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Intellectual disability - microarray and sequencing v3.1622 WNK3 Arina Puzriakova Mode of inheritance for gene: WNK3 was changed from X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males) to X-LINKED: hemizygous mutation in males, biallelic mutations in females
Intellectual disability - microarray and sequencing v3.1621 WNK3 Arina Puzriakova Publications for gene: WNK3 were set to 26350204
Intellectual disability - microarray and sequencing v3.1620 WNK3 Arina Puzriakova Phenotypes for gene: WNK3 were changed from X_linked intellectual disability; XLID to X-linked intellectual disability, MONDO:0100284
Intellectual disability - microarray and sequencing v3.1619 WNK3 Arina Puzriakova Classified gene: WNK3 as Amber List (moderate evidence)
Intellectual disability - microarray and sequencing v3.1619 WNK3 Arina Puzriakova Added comment: Comment on list classification: There is now enough evidence to promote this gene to Green at the next GMS review - at least 14 individuals from 6 unrelated families, all presenting with ID in association with variants in the WNK3 gene.
Intellectual disability - microarray and sequencing v3.1619 WNK3 Arina Puzriakova Gene: wnk3 has been classified as Amber List (Moderate Evidence).
Intellectual disability - microarray and sequencing v3.1618 WNK3 Arina Puzriakova Tag Q3_22_rating tag was added to gene: WNK3.
Intellectual disability - microarray and sequencing v3.1618 WNK3 Arina Puzriakova reviewed gene: WNK3: Rating: GREEN; Mode of pathogenicity: None; Publications: 35678782; Phenotypes: Intellectual disability, MONDO:0001071; Mode of inheritance: X-LINKED: hemizygous mutation in males, biallelic mutations in females