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Primary immunodeficiency or monogenic inflammatory bowel disease v4.100 CD81 Achchuthan Shanmugasundram Classified gene: CD81 as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v4.100 CD81 Achchuthan Shanmugasundram Added comment: Comment on list classification: There are two unrelated cases and functional evidence available in support of the association of this gene to common variable immunodeficiency (MIM #613496). Hence, this gene can be promoted to green rating in the next GMS review.
Primary immunodeficiency or monogenic inflammatory bowel disease v4.100 CD81 Achchuthan Shanmugasundram Gene: cd81 has been classified as Amber List (Moderate Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v4.99 CD81 Achchuthan Shanmugasundram Phenotypes for gene: CD81 were changed from Common variable immunodeficiency disorders (CVID); Immunodeficiency, common variable 6, 613496; hypogammaglobulinaemia; CD81 deficiency; Isolated IgG subclass deficiency; Predominantly Antibody Deficiencies; Recurrent infections, may have glomerulonephritis to Immunodeficiency, common variable, 6, OMIM:613496
Primary immunodeficiency or monogenic inflammatory bowel disease v4.98 CD81 Achchuthan Shanmugasundram Publications for gene: CD81 were set to 27250108; 14530327; 20237408; 32048120; 32086639
Primary immunodeficiency or monogenic inflammatory bowel disease v4.97 CD81 Achchuthan Shanmugasundram Tag Q4_23_promote_green tag was added to gene: CD81.
Tag Q4_23_NHS_review tag was added to gene: CD81.
Primary immunodeficiency or monogenic inflammatory bowel disease v4.97 CD81 Achchuthan Shanmugasundram reviewed gene: CD81: Rating: GREEN; Mode of pathogenicity: None; Publications: 20237408, 25739915, 35849269; Phenotypes: Immunodeficiency, common variable, 6, OMIM:613496; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease v4.41 CD81 Hannah Knight reviewed gene: CD81: Rating: AMBER; Mode of pathogenicity: None; Publications: 35849269; Phenotypes: Immunodeficiency, common variable, 6; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease v2.34 CD81 Louise Daugherty Source IUIS Classification December 2019 was added to CD81.
Added phenotypes Recurrent infections, may have glomerulonephritis; Predominantly Antibody Deficiencies for gene: CD81
Publications for gene CD81 were updated from 20237408; 14530327; 27250108 to 27250108; 14530327; 20237408; 32048120; 32086639
Primary immunodeficiency or monogenic inflammatory bowel disease CD81 Louise Daugherty commented on gene: CD81
Primary immunodeficiency or monogenic inflammatory bowel disease CD81 Louise Daugherty marked gene: CD81 as ready
Primary immunodeficiency or monogenic inflammatory bowel disease CD81 Louise Daugherty commented on gene: CD81
Primary immunodeficiency or monogenic inflammatory bowel disease CD81 Sophie Hambleton reviewed gene: CD81
Primary immunodeficiency or monogenic inflammatory bowel disease CD81 Louise Daugherty commented on gene: CD81
Primary immunodeficiency or monogenic inflammatory bowel disease CD81 Louise Daugherty commented on CD81
Primary immunodeficiency or monogenic inflammatory bowel disease CD81 Louise Daugherty commented on CD81
Primary immunodeficiency or monogenic inflammatory bowel disease CD81 Louise Daugherty commented on CD81
Primary immunodeficiency or monogenic inflammatory bowel disease CD81 Louise Daugherty reviewed CD81
Primary immunodeficiency or monogenic inflammatory bowel disease CD81 Louise Daugherty Added gene to panel
Primary immunodeficiency or monogenic inflammatory bowel disease CD81 Louise Daugherty Added gene to panel