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Primary immunodeficiency or monogenic inflammatory bowel disease v2.572 CFHR5 Arina Puzriakova commented on gene: CFHR5
Primary immunodeficiency or monogenic inflammatory bowel disease v2.571 CFHR5 Arina Puzriakova Source Expert Review Red was added to CFHR5.
Rating Changed from Amber List (moderate evidence) to Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.555 CFHR5 Dmitrijs Rots reviewed gene: CFHR5: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None
Primary immunodeficiency or monogenic inflammatory bowel disease v2.34 CFHR5 Louise Daugherty Source IUIS Classification December 2019 was added to CFHR5.
Added phenotypes Older onset atypical hemolytic-uremic syndrome, disseminated neisserial infections for gene: CFHR5
Publications for gene CFHR5 were updated from 20800271; 22503529; 28673452 to 32048120; 28673452; 20800271; 22503529; 32086639
Primary immunodeficiency or monogenic inflammatory bowel disease v1.130 CFHR5 Louise Daugherty commented on gene: CFHR5: Glomerulonephritis with C3 deposits (green re association - ?phenotype)
Primary immunodeficiency or monogenic inflammatory bowel disease v1.116 CFHR5 Louise Daugherty commented on gene: CFHR5: Gene rating submitted by Tracy Briggs, David Gokhale and Abigal Rousseau on behalf of North West GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email on 20th June the Specialist Test Group all agreed there is only enough evidence to rate this gene Amber.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.116 CFHR5 Louise Daugherty commented on gene: CFHR5: Gene rating submitted by Kimberly Gilmour and Austen Worth on behalf of London North GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email 6th September the Specialist Test Group all agreed there is only enough evidence to rate this gene Amber
Primary immunodeficiency or monogenic inflammatory bowel disease v1.115 CFHR5 Kimberly Gilmour reviewed gene: CFHR5: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.114 CFHR5 Tracy Briggs reviewed gene: CFHR5: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.64 CFHR5 Louise Daugherty ERCC3 was changed to CFHR5
Primary immunodeficiency or monogenic inflammatory bowel disease v1.63 CFHR5 Louise Daugherty Source North West GLH was added to CFHR5.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.62 CFHR5 Louise Daugherty Source London North GLH was added to CFHR5.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.61 CFHR5 Louise Daugherty Source NHS GMS was added to CFHR5.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.36 CFHR5 Louise Daugherty Added comment: Comment on mode of inheritance: Changed MOI in view of IUIS data
Primary immunodeficiency or monogenic inflammatory bowel disease v1.36 CFHR5 Louise Daugherty Mode of inheritance for gene: CFHR5 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease CFHR5 Louise Daugherty commented on gene: CFHR5
Primary immunodeficiency or monogenic inflammatory bowel disease CFHR5 Louise Daugherty commented on gene: CFHR5
Primary immunodeficiency or monogenic inflammatory bowel disease CFHR5 Louise Daugherty commented on gene: CFHR5
Primary immunodeficiency or monogenic inflammatory bowel disease CFHR5 Sophie Hambleton commented on gene: CFHR5
Primary immunodeficiency or monogenic inflammatory bowel disease CFHR5 Sophie Hambleton reviewed gene: CFHR5
Primary immunodeficiency or monogenic inflammatory bowel disease CFHR5 Louise Daugherty marked gene: CFHR5 as ready
Primary immunodeficiency or monogenic inflammatory bowel disease CFHR5 Louise Daugherty commented on gene: CFHR5
Primary immunodeficiency or monogenic inflammatory bowel disease CFHR5 Louise Daugherty commented on gene: CFHR5
Primary immunodeficiency or monogenic inflammatory bowel disease CFHR5 Louise Daugherty commented on gene: CFHR5
Primary immunodeficiency or monogenic inflammatory bowel disease CFHR5 Louise Daugherty commented on CFHR5
Primary immunodeficiency or monogenic inflammatory bowel disease CFHR5 Louise Daugherty reviewed CFHR5
Primary immunodeficiency or monogenic inflammatory bowel disease CFHR5 Louise Daugherty Added gene to panel
Primary immunodeficiency or monogenic inflammatory bowel disease CFHR5 Louise Daugherty Added gene to panel