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Primary immunodeficiency or monogenic inflammatory bowel disease v2.245 DOCK8 Eleanor Williams Classified gene: DOCK8 as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.245 DOCK8 Eleanor Williams Added comment: Comment on list classification: Changed rating of gene from Red to Green. This gene was rated as Green in v2.208 and incorrectly automatically demoted to Red in v2.209. This was due to a defect in the automatic PanelApp uploading tool when a set of publications was added to the panel with the source ‘Other’, and under certain conditions associated to previous sources listed, resulted in the rating of the gene being automatically changed when it should not have been.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.245 DOCK8 Eleanor Williams Gene: dock8 has been classified as Green List (High Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.209 DOCK8 Eleanor Williams Source Other was added to DOCK8.
Publications for gene DOCK8 were updated from 19776401; 20004785; 25627830; 25724123 to 25724123; 20004785; 25627830; 19776401
Rating Changed from Green List (high evidence) to Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.208 DOCK8 Eleanor Williams reviewed gene: DOCK8: Rating: ; Mode of pathogenicity: ; Publications: 25724123, 25627830, 19776401, 20004785; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v2.196 DOCK8 Eleanor Williams Phenotypes for gene: DOCK8 were changed from Hyper-IgE recurrent infection syndrome, autosomal recessive; Hyper-IgE recurrent infection syndrome; impaired T cell function, Atopy, cutaneous viral infections; Combined immunodeficiency; Hyper IgE syndrome (HIES); Low NK cells with poor function, eosinophilia, recurrent infections, cutaneous viral, fungal and staphylococcal infections, severe atopy, cancer diathesis; Immunodeficiencies affecting cellular and humoral immunity to Hyper-IgE recurrent infection syndrome, autosomal recessive, 243700; Hyper-IgE recurrent infection syndrome; impaired T cell function, Atopy, cutaneous viral infections; Combined immunodeficiency; Hyper IgE syndrome (HIES); Low NK cells with poor function, eosinophilia, recurrent infections, cutaneous viral, fungal and staphylococcal infections, severe atopy, cancer diathesis; Immunodeficiencies affecting cellular and humoral immunity
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 DOCK8 Louise Daugherty commented on gene: DOCK8: Gene rating submitted by Kimberly Gilmour and Austen Worth on behalf of London North GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email 6th September the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 DOCK8 Louise Daugherty commented on gene: DOCK8: Gene rating submitted by Tracy Briggs, David Gokhale and Abigal Rousseau on behalf of North West GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email on 20th June the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 DOCK8 Kimberly Gilmour reviewed gene: DOCK8: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 DOCK8 Tracy Briggs reviewed gene: DOCK8: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.60 DOCK8 Louise Daugherty Source NHS GMS was added to DOCK8.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.59 DOCK8 Louise Daugherty Source North West GLH was added to DOCK8.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.58 DOCK8 Louise Daugherty Source London North GLH was added to DOCK8.
Primary immunodeficiency or monogenic inflammatory bowel disease DOCK8 Louise Daugherty commented on gene: DOCK8
Primary immunodeficiency or monogenic inflammatory bowel disease DOCK8 Louise Daugherty marked gene: DOCK8 as ready
Primary immunodeficiency or monogenic inflammatory bowel disease DOCK8 Louise Daugherty commented on DOCK8
Primary immunodeficiency or monogenic inflammatory bowel disease DOCK8 Louise Daugherty commented on DOCK8
Primary immunodeficiency or monogenic inflammatory bowel disease DOCK8 Louise Daugherty reviewed DOCK8
Primary immunodeficiency or monogenic inflammatory bowel disease DOCK8 Louise Daugherty Added gene to panel