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Primary immunodeficiency or monogenic inflammatory bowel disease v2.254 ICOS Eleanor Williams Classified gene: ICOS as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.254 ICOS Eleanor Williams Added comment: Comment on list classification: Changed rating of gene from Red to Green. This gene was rated as Green in v2.208 and incorrectly automatically demoted to Red in v2.209. This was due to a defect in the automatic PanelApp uploading tool when a set of publications was added to the panel with the source ‘Other’, and under certain conditions associated to previous sources listed, resulted in the rating of the gene being automatically changed when it should not have been.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.254 ICOS Eleanor Williams Gene: icos has been classified as Green List (High Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.209 ICOS Eleanor Williams Source Other was added to ICOS.
Publications for gene ICOS were updated from 29867948; 28861081; 12577056; 15507387; 19380800; 25678089; 26399252; 10413651; 29867948; 25678089; 24795713; 29226302; 29226301 to 10413651; 26399252; 25678089; 29226301; 19380800; 28861081; 15507387; 24795713; 12577056; 29226302; 29867948
Rating Changed from Green List (high evidence) to Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.208 ICOS Eleanor Williams reviewed gene: ICOS: Rating: ; Mode of pathogenicity: ; Publications: 12577056, 28861081; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v2.166 ICOSLG Sarah Leigh Classified gene: ICOSLG as Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.166 ICOSLG Sarah Leigh Gene: icoslg has been classified as Red List (Low Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.165 ICOSLG Sarah Leigh Classified gene: ICOSLG as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.165 ICOSLG Sarah Leigh Gene: icoslg has been classified as Amber List (Moderate Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.164 ICOSLG Sarah Leigh Publications for gene: ICOSLG were set to 32086639; 32048120; 30498080; 31532372
Primary immunodeficiency or monogenic inflammatory bowel disease v2.163 ICOSLG Sarah Leigh Publications for gene: ICOSLG were set to 32086639; 32048120; 30498080
Primary immunodeficiency or monogenic inflammatory bowel disease v2.51 ICOSLG Zornitza Stark reviewed gene: ICOSLG: Rating: AMBER; Mode of pathogenicity: None; Publications: 31532372, 30498080; Phenotypes: Combined immunodeficiency, recurrent bacterial and viral infections, neutropaenia; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease v2.36 ICOSLG Louise Daugherty edited their review of gene: ICOSLG: Added comment: Added publication referenced by IUIS december 2019 update; Changed rating: AMBER; Changed publications: 30498080
Primary immunodeficiency or monogenic inflammatory bowel disease v2.35 ICOSLG Louise Daugherty Publications for gene ICOSLG were updated from 32048120; 32086639 to 32086639; 32048120; 30498080
Primary immunodeficiency or monogenic inflammatory bowel disease v2.34 ICOSLG Louise Daugherty Source IUIS Classification December 2019 was added to ICOSLG.
Mode of inheritance for gene ICOSLG was changed from to BIALLELIC, autosomal or pseudoautosomal
Added phenotypes Recurrent bacterial and viral infections; Immunodeficiencies affecting cellular and humoral immunity for gene: ICOSLG
Publications for gene ICOSLG were updated from to 32048120; 32086639
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 ICOS Louise Daugherty commented on gene: ICOS: Gene rating submitted by Kimberly Gilmour and Austen Worth on behalf of London North GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email 6th September the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 ICOS Louise Daugherty commented on gene: ICOS: Gene rating submitted by Tracy Briggs, David Gokhale and Abigal Rousseau on behalf of North West GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email on 20th June the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 ICOS Kimberly Gilmour reviewed gene: ICOS: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 ICOS Tracy Briggs reviewed gene: ICOS: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.60 ICOS Louise Daugherty Source NHS GMS was added to ICOS.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.59 ICOS Louise Daugherty Source North West GLH was added to ICOS.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.58 ICOS Louise Daugherty Source London North GLH was added to ICOS.
Primary immunodeficiency or monogenic inflammatory bowel disease ICOS Louise Daugherty marked gene: ICOS as ready
Primary immunodeficiency or monogenic inflammatory bowel disease ICOSLG Louise Daugherty classified ICOSLG as Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease ICOS Louise Daugherty commented on gene: ICOS
Primary immunodeficiency or monogenic inflammatory bowel disease ICOSLG Sophie Hambleton reviewed gene: ICOSLG
Primary immunodeficiency or monogenic inflammatory bowel disease ICOSLG Louise Daugherty classified ICOSLG as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease ICOS Louise Daugherty classified ICOS as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease ICOS Louise Daugherty edited their review of gene: ICOS
Primary immunodeficiency or monogenic inflammatory bowel disease ICOS Louise Daugherty commented on gene: ICOS
Primary immunodeficiency or monogenic inflammatory bowel disease ICOS Louise Daugherty commented on gene: ICOS
Primary immunodeficiency or monogenic inflammatory bowel disease ICOS Louise Daugherty commented on gene: ICOS
Primary immunodeficiency or monogenic inflammatory bowel disease ICOS Louise Daugherty commented on gene: ICOS
Primary immunodeficiency or monogenic inflammatory bowel disease ICOS Louise Daugherty commented on gene: ICOS
Primary immunodeficiency or monogenic inflammatory bowel disease ICOS Louise Daugherty commented on ICOS
Primary immunodeficiency or monogenic inflammatory bowel disease ICOS Louise Daugherty commented on ICOS
Primary immunodeficiency or monogenic inflammatory bowel disease ICOS Louise Daugherty commented on ICOS
Primary immunodeficiency or monogenic inflammatory bowel disease ICOS Louise Daugherty reviewed ICOS
Primary immunodeficiency or monogenic inflammatory bowel disease ICOS Louise Daugherty Added gene to panel