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Primary immunodeficiency or monogenic inflammatory bowel disease v3.4 IFNAR2 Achchuthan Shanmugasundram Tag Q3_22_rating was removed from gene: IFNAR2.
Primary immunodeficiency or monogenic inflammatory bowel disease v3.4 IFNAR2 Achchuthan Shanmugasundram reviewed gene: IFNAR2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v3.3 IFNAR2 Achchuthan Shanmugasundram Source Expert Review Green was added to IFNAR2.
Source NHS GMS was added to IFNAR2.
Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.577 IFNAR2 Arina Puzriakova Classified gene: IFNAR2 as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.577 IFNAR2 Arina Puzriakova Added comment: Comment on list classification: There is sufficient evidence to promote this gene to Green at the next GMS panel review.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.577 IFNAR2 Arina Puzriakova Gene: ifnar2 has been classified as Amber List (Moderate Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.576 IFNAR2 Arina Puzriakova Publications for gene: IFNAR2 were set to 32048120; 26424569; 32086639
Primary immunodeficiency or monogenic inflammatory bowel disease v2.575 IFNAR2 Arina Puzriakova Tag Q3_22_rating tag was added to gene: IFNAR2.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.575 IFNAR2 Arina Puzriakova reviewed gene: IFNAR2: Rating: GREEN; Mode of pathogenicity: None; Publications: 26424569, 33193576, 33544838, 35442417, 35944424; Phenotypes: Immunodeficiency 45, OMIM:616669; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease v2.575 IFNAR2 Arina Puzriakova Phenotypes for gene: IFNAR2 were changed from Defects in Intrinsic and Innate Immunity; Severe viral infections (disseminated vaccine-strain measles, HHV6); ?Immunodeficiency 45, 616669 to Immunodeficiency 45, OMIM:616669
Primary immunodeficiency or monogenic inflammatory bowel disease v2.574 IFNAR2 Dmitrijs Rots changed review comment from: In review 35986347 report on family with severe COVID and biallelic IFNAR2 variant.; to: In review 35986347 report on study + family with severe COVID and biallelic IFNAR2 variant.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.574 IFNAR2 Dmitrijs Rots reviewed gene: IFNAR2: Rating: AMBER; Mode of pathogenicity: None; Publications: 35986347; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease v2.34 IFNAR2 Louise Daugherty Source IUIS Classification December 2019 was added to IFNAR2.
Added phenotypes Severe viral infections (disseminated vaccine-strain measles, HHV6) for gene: IFNAR2
Publications for gene IFNAR2 were updated from 26424569 to 32048120; 26424569; 32086639
Primary immunodeficiency or monogenic inflammatory bowel disease IFNAR2 Louise Daugherty marked gene: IFNAR2 as ready
Primary immunodeficiency or monogenic inflammatory bowel disease IFNAR2 Louise Daugherty commented on gene: IFNAR2
Primary immunodeficiency or monogenic inflammatory bowel disease IFNAR2 Louise Daugherty reviewed gene: IFNAR2
Primary immunodeficiency or monogenic inflammatory bowel disease IFNAR2 Sophie Hambleton reviewed gene: IFNAR2
Primary immunodeficiency or monogenic inflammatory bowel disease IFNAR2 Louise Daugherty Added gene to panel