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Primary immunodeficiency or monogenic inflammatory bowel disease v3.4 | IFNAR2 | Achchuthan Shanmugasundram Tag Q3_22_rating was removed from gene: IFNAR2. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease v3.4 | IFNAR2 | Achchuthan Shanmugasundram reviewed gene: IFNAR2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease v3.3 | IFNAR2 |
Achchuthan Shanmugasundram Source Expert Review Green was added to IFNAR2. Source NHS GMS was added to IFNAR2. Rating Changed from Amber List (moderate evidence) to Green List (high evidence) |
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Primary immunodeficiency or monogenic inflammatory bowel disease v2.577 | IFNAR2 | Arina Puzriakova Classified gene: IFNAR2 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease v2.577 | IFNAR2 | Arina Puzriakova Added comment: Comment on list classification: There is sufficient evidence to promote this gene to Green at the next GMS panel review. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease v2.577 | IFNAR2 | Arina Puzriakova Gene: ifnar2 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease v2.576 | IFNAR2 | Arina Puzriakova Publications for gene: IFNAR2 were set to 32048120; 26424569; 32086639 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease v2.575 | IFNAR2 | Arina Puzriakova Tag Q3_22_rating tag was added to gene: IFNAR2. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease v2.575 | IFNAR2 | Arina Puzriakova reviewed gene: IFNAR2: Rating: GREEN; Mode of pathogenicity: None; Publications: 26424569, 33193576, 33544838, 35442417, 35944424; Phenotypes: Immunodeficiency 45, OMIM:616669; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease v2.575 | IFNAR2 | Arina Puzriakova Phenotypes for gene: IFNAR2 were changed from Defects in Intrinsic and Innate Immunity; Severe viral infections (disseminated vaccine-strain measles, HHV6); ?Immunodeficiency 45, 616669 to Immunodeficiency 45, OMIM:616669 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease v2.574 | IFNAR2 | Dmitrijs Rots changed review comment from: In review 35986347 report on family with severe COVID and biallelic IFNAR2 variant.; to: In review 35986347 report on study + family with severe COVID and biallelic IFNAR2 variant. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease v2.574 | IFNAR2 | Dmitrijs Rots reviewed gene: IFNAR2: Rating: AMBER; Mode of pathogenicity: None; Publications: 35986347; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease v2.34 | IFNAR2 |
Louise Daugherty Source IUIS Classification December 2019 was added to IFNAR2. Added phenotypes Severe viral infections (disseminated vaccine-strain measles, HHV6) for gene: IFNAR2 Publications for gene IFNAR2 were updated from 26424569 to 32048120; 26424569; 32086639 |
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Primary immunodeficiency or monogenic inflammatory bowel disease | IFNAR2 | Louise Daugherty marked gene: IFNAR2 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease | IFNAR2 | Louise Daugherty commented on gene: IFNAR2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease | IFNAR2 | Louise Daugherty reviewed gene: IFNAR2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease | IFNAR2 | Sophie Hambleton reviewed gene: IFNAR2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Primary immunodeficiency or monogenic inflammatory bowel disease | IFNAR2 | Louise Daugherty Added gene to panel |