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Primary immunodeficiency or monogenic inflammatory bowel disease v4.123 IL21R Arina Puzriakova Phenotypes for gene: IL21R were changed from Immunodeficiency 56, 615207; Immunodeficiency, primary, autosomal recessive, IL21R-related; Atypical Severe Combined Immunodeficiency (Atypical SCID); Combined immunodeficiency; Omenn syndrome; Severe combined immunodeficiency (SCID); IL-21R deficiency; Recurrent infections, Pneumocystis jiroveci, Cryptosporidium infections and liver disease; Immunodeficiencies affecting cellular and humoral immunity to Immunodeficiency 56, OMIM:615207
Primary immunodeficiency or monogenic inflammatory bowel disease v2.261 IL21R Eleanor Williams Classified gene: IL21R as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.261 IL21R Eleanor Williams Added comment: Comment on list classification: Changed rating of gene from Red to Green. This gene was rated as Green in v2.208 and incorrectly automatically demoted to Red in v2.209. This was due to a defect in the automatic PanelApp uploading tool when a set of publications was added to the panel with the source ‘Other’, and under certain conditions associated to previous sources listed, resulted in the rating of the gene being automatically changed when it should not have been.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.261 IL21R Eleanor Williams Gene: il21r has been classified as Green List (High Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.209 IL21R Eleanor Williams Source Other was added to IL21R.
Rating Changed from Green List (high evidence) to Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.208 IL21R Eleanor Williams reviewed gene: IL21R: Rating: ; Mode of pathogenicity: ; Publications: 23440042, 12700598; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 IL21R Louise Daugherty commented on gene: IL21R: Gene rating submitted by Kimberly Gilmour and Austen Worth on behalf of London North GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email 6th September the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 IL21R Louise Daugherty commented on gene: IL21R: Gene rating submitted by Tracy Briggs, David Gokhale and Abigal Rousseau on behalf of North West GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email on 20th June the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 IL21R Kimberly Gilmour reviewed gene: IL21R: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 IL21R Tracy Briggs reviewed gene: IL21R: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.60 IL21R Louise Daugherty Source NHS GMS was added to IL21R.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.59 IL21R Louise Daugherty Source North West GLH was added to IL21R.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.58 IL21R Louise Daugherty Source London North GLH was added to IL21R.
Primary immunodeficiency or monogenic inflammatory bowel disease IL21R Louise Daugherty edited their review of gene: IL21R
Primary immunodeficiency or monogenic inflammatory bowel disease IL21R Louise Daugherty marked gene: IL21R as ready
Primary immunodeficiency or monogenic inflammatory bowel disease IL21R Louise Daugherty classified IL21R as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease IL21R Sophie Hambleton reviewed gene: IL21R
Primary immunodeficiency or monogenic inflammatory bowel disease IL21R Louise Daugherty commented on IL21R
Primary immunodeficiency or monogenic inflammatory bowel disease IL21R Louise Daugherty commented on IL21R
Primary immunodeficiency or monogenic inflammatory bowel disease IL21R Louise Daugherty commented on IL21R
Primary immunodeficiency or monogenic inflammatory bowel disease IL21R Louise Daugherty reviewed IL21R
Primary immunodeficiency or monogenic inflammatory bowel disease IL21R Louise Daugherty Added gene to panel
Primary immunodeficiency or monogenic inflammatory bowel disease IL21R Louise Daugherty Added gene to panel