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Primary immunodeficiency or monogenic inflammatory bowel disease v4.37 IRF7 Achchuthan Shanmugasundram Tag Q2_23_promote_green was removed from gene: IRF7.
Primary immunodeficiency or monogenic inflammatory bowel disease v4.37 IRF7 Arina Puzriakova edited their review of gene: IRF7: Added comment: The rating of this gene has been updated to Green following NHS Genomic Medicine Service approval.; Changed rating: GREEN
Primary immunodeficiency or monogenic inflammatory bowel disease v4.36 IRF7 Achchuthan Shanmugasundram Source Expert Review Green was added to IRF7.
Source NHS GMS was added to IRF7.
Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v4.17 IRF7 Arina Puzriakova Classified gene: IRF7 as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v4.17 IRF7 Arina Puzriakova Added comment: Comment on list classification: There is sufficient evidence to promote this gene to Green at the next GMS panel update. At least 7 families reported. Individuals with biallelic variants in the IRF7 gene appear more prone to viral infections of the respiratory tract.
Primary immunodeficiency or monogenic inflammatory bowel disease v4.17 IRF7 Arina Puzriakova Gene: irf7 has been classified as Amber List (Moderate Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v4.16 IRF7 Arina Puzriakova Tag Q2_23_promote_green tag was added to gene: IRF7.
Primary immunodeficiency or monogenic inflammatory bowel disease v4.16 IRF7 Arina Puzriakova Phenotypes for gene: IRF7 were changed from Severe influenza; Defects in Intrinsic and Innate Immunity; IRF7 deficiency; ?Immunodeficiency 39, 616345; Severe influenza disease to Immunodeficiency 39 , OMIM:616345
Primary immunodeficiency or monogenic inflammatory bowel disease v2.582 IRF7 Dmitrijs Rots edited their review of gene: IRF7: Added comment: 7 families in total reported. Enough evidence for green classification.; Changed rating: GREEN; Changed publications to: 35986347, 35670811
Primary immunodeficiency or monogenic inflammatory bowel disease v2.574 IRF7 Dmitrijs Rots reviewed gene: IRF7: Rating: AMBER; Mode of pathogenicity: None; Publications: 35986347; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease v2.34 IRF7 Louise Daugherty Source IUIS Classification December 2019 was added to IRF7.
Added phenotypes Severe influenza disease for gene: IRF7
Publications for gene IRF7 were updated from 25814066; 26761402; 9315633 to 26761402; 25814066; 9315633; 32048120; 32086639
Primary immunodeficiency or monogenic inflammatory bowel disease IRF7 Louise Daugherty commented on gene: IRF7
Primary immunodeficiency or monogenic inflammatory bowel disease IRF7 Louise Daugherty marked gene: IRF7 as ready
Primary immunodeficiency or monogenic inflammatory bowel disease IRF7 Louise Daugherty classified IRF7 as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease IRF7 Sophie Hambleton reviewed gene: IRF7
Primary immunodeficiency or monogenic inflammatory bowel disease IRF7 Louise Daugherty commented on IRF7
Primary immunodeficiency or monogenic inflammatory bowel disease IRF7 Louise Daugherty reviewed IRF7
Primary immunodeficiency or monogenic inflammatory bowel disease IRF7 Louise Daugherty Added gene to panel
Primary immunodeficiency or monogenic inflammatory bowel disease IRF7 Louise Daugherty Added gene to panel