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Primary immunodeficiency or monogenic inflammatory bowel disease v2.268 JAK3 Eleanor Williams Classified gene: JAK3 as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.268 JAK3 Eleanor Williams Added comment: Comment on list classification: Changed rating of gene from Red to Green. This gene was rated as Green in v2.208 and incorrectly automatically demoted to Red in v2.209. This was due to a defect in the automatic PanelApp uploading tool when a set of publications was added to the panel with the source ‘Other’, and under certain conditions associated to previous sources listed, resulted in the rating of the gene being automatically changed when it should not have been.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.268 JAK3 Eleanor Williams Gene: jak3 has been classified as Green List (High Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.209 JAK3 Eleanor Williams Source Other was added to JAK3.
Publications for gene JAK3 were updated from to 7481768; 7659163
Rating Changed from Green List (high evidence) to Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.208 JAK3 Eleanor Williams reviewed gene: JAK3: Rating: ; Mode of pathogenicity: ; Publications: 7659163, 7481768; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 JAK3 Louise Daugherty commented on gene: JAK3: Gene rating submitted by Kimberly Gilmour and Austen Worth on behalf of London North GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email 6th September the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 JAK3 Louise Daugherty commented on gene: JAK3: Gene rating submitted by Tracy Briggs, David Gokhale and Abigal Rousseau on behalf of North West GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email on 20th June the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 JAK3 Kimberly Gilmour commented on gene: JAK3: agree with green gene
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 JAK3 Tracy Briggs commented on gene: JAK3: YES- this is covered on our targeted exome
Primary immunodeficiency or monogenic inflammatory bowel disease v1.60 JAK3 Louise Daugherty Source NHS GMS was added to JAK3.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.59 JAK3 Louise Daugherty Source North West GLH was added to JAK3.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.58 JAK3 Louise Daugherty Source London North GLH was added to JAK3.
Primary immunodeficiency or monogenic inflammatory bowel disease JAK3 Louise Daugherty commented on gene: JAK3
Primary immunodeficiency or monogenic inflammatory bowel disease JAK3 Louise Daugherty marked gene: JAK3 as ready
Primary immunodeficiency or monogenic inflammatory bowel disease JAK3 Louise Daugherty commented on JAK3
Primary immunodeficiency or monogenic inflammatory bowel disease JAK3 Louise Daugherty commented on JAK3
Primary immunodeficiency or monogenic inflammatory bowel disease JAK3 Louise Daugherty reviewed JAK3
Primary immunodeficiency or monogenic inflammatory bowel disease JAK3 Louise Daugherty Added gene to panel