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Primary immunodeficiency or monogenic inflammatory bowel disease v2.270 LCK Eleanor Williams Classified gene: LCK as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.270 LCK Eleanor Williams Added comment: Comment on list classification: Changed rating of gene from Red to Green. This gene was rated as Green in v2.208 and incorrectly automatically demoted to Red in v2.209. This was due to a defect in the automatic PanelApp uploading tool when a set of publications was added to the panel with the source ‘Other’, and under certain conditions associated to previous sources listed, resulted in the rating of the gene being automatically changed when it should not have been.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.270 LCK Eleanor Williams Gene: lck has been classified as Green List (High Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.209 LCK Eleanor Williams Source Other was added to LCK.
Publications for gene LCK were updated from 22985903; 9664084; 11351273 to 22985903; 11351273; 9664084
Rating Changed from Green List (high evidence) to Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.208 LCK Eleanor Williams reviewed gene: LCK: Rating: ; Mode of pathogenicity: ; Publications: 22985903, 11351273, 9664084; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 LCK Louise Daugherty commented on gene: LCK: Gene rating submitted by Kimberly Gilmour and Austen Worth on behalf of London North GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email 6th September the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 LCK Louise Daugherty commented on gene: LCK: Gene rating submitted by Tracy Briggs, David Gokhale and Abigal Rousseau on behalf of North West GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email on 20th June the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 LCK Kimberly Gilmour reviewed gene: LCK: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 LCK Tracy Briggs reviewed gene: LCK: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.60 LCK Louise Daugherty Source NHS GMS was added to LCK.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.59 LCK Louise Daugherty Source North West GLH was added to LCK.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.58 LCK Louise Daugherty Source London North GLH was added to LCK.
Primary immunodeficiency or monogenic inflammatory bowel disease LCK Louise Daugherty edited their review of gene: LCK
Primary immunodeficiency or monogenic inflammatory bowel disease LCK Louise Daugherty marked gene: LCK as ready
Primary immunodeficiency or monogenic inflammatory bowel disease LCK Louise Daugherty classified LCK as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease LCK Sophie Hambleton reviewed gene: LCK
Primary immunodeficiency or monogenic inflammatory bowel disease LCK Louise Daugherty classified LCK as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease LCK Louise Daugherty commented on LCK
Primary immunodeficiency or monogenic inflammatory bowel disease LCK Louise Daugherty commented on LCK
Primary immunodeficiency or monogenic inflammatory bowel disease LCK Louise Daugherty commented on LCK
Primary immunodeficiency or monogenic inflammatory bowel disease LCK Louise Daugherty reviewed LCK
Primary immunodeficiency or monogenic inflammatory bowel disease LCK Louise Daugherty Added gene to panel
Primary immunodeficiency or monogenic inflammatory bowel disease LCK Louise Daugherty Added gene to panel