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Primary immunodeficiency or monogenic inflammatory bowel disease v2.51 MRE11 Sarah Leigh Publications for gene: MRE11 were set to 8445618; 10612394; 15574463; 32212377
Primary immunodeficiency or monogenic inflammatory bowel disease v2.50 MRE11 Sarah Leigh changed review comment from: Comment on list classification: Immunodeficiency does not appear to be a feature of Ataxia-telangiectasia-like disorder 1 604391. However, as part of the MRE11-RAD50-NBS1 Complex it is part of the core conductor for the initial and sustained responses to DNA double-strand breaks, stalled replication forks, dysfunctional telomeres, and viral DNA infection. Hence, variants in MRE11, could reduce the response to viral DNA integration in host cells,allowing infections to be propogated. ; to: Comment on list classification: Immunodeficiency does not appear to be a feature of Ataxia-telangiectasia-like disorder 1 604391. However, as part of the MRE11-RAD50-NBS1 Complex it is part of the core conductor for the initial and sustained responses to DNA double-strand breaks, stalled replication forks, dysfunctional telomeres, and viral DNA infection (pmid 29709199). Hence, variants in MRE11, could reduce the response to viral DNA integration in host cells,allowing infections to be propogated.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.50 MRE11 Sarah Leigh changed review comment from: Comment on list classification: Immunodeficiency does not appear to be a feature of Ataxia-telangiectasia-like disorder 1 604391; to: Comment on list classification: Immunodeficiency does not appear to be a feature of Ataxia-telangiectasia-like disorder 1 604391. However, as part of the MRE11-RAD50-NBS1 Complex it is part of the core conductor for the initial and sustained responses to DNA double-strand breaks, stalled replication forks, dysfunctional telomeres, and viral DNA infection. Hence, variants in MRE11, could reduce the response to viral DNA integration in host cells,allowing infections to be propogated.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.50 MRE11 Sarah Leigh Classified gene: MRE11 as Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.50 MRE11 Sarah Leigh Added comment: Comment on list classification: Immunodeficiency does not appear to be a feature of Ataxia-telangiectasia-like disorder 1 604391
Primary immunodeficiency or monogenic inflammatory bowel disease v2.50 MRE11 Sarah Leigh Gene: mre11 has been classified as Red List (Low Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.49 MRE11 Sarah Leigh Publications for gene: MRE11 were set to 8445618; 10612394; 15574463
Primary immunodeficiency or monogenic inflammatory bowel disease v2.48 MRE11 Sarah Leigh Publications for gene: MRE11 were set to 8445618; 10612394; 15574463
Primary immunodeficiency or monogenic inflammatory bowel disease v2.46 MRE11 Sarah Leigh Publications for gene: MRE11 were set to 8445618; 10612394
Primary immunodeficiency or monogenic inflammatory bowel disease MRE11 Louise Daugherty marked gene: MRE11 as ready
Primary immunodeficiency or monogenic inflammatory bowel disease MRE11 Louise Daugherty classified MRE11 as Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease MRE11 Sophie Hambleton reviewed gene: MRE11
Primary immunodeficiency or monogenic inflammatory bowel disease MRE11 Louise Daugherty commented on gene: MRE11
Primary immunodeficiency or monogenic inflammatory bowel disease MRE11 Sarah Leigh classified MRE11 as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease MRE11 Sarah Leigh commented on MRE11
Primary immunodeficiency or monogenic inflammatory bowel disease MRE11 Sarah Leigh classified MRE11 as Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease MRE11 Louise Daugherty commented on MRE11
Primary immunodeficiency or monogenic inflammatory bowel disease MRE11 Louise Daugherty commented on MRE11
Primary immunodeficiency or monogenic inflammatory bowel disease MRE11 Louise Daugherty commented on MRE11
Primary immunodeficiency or monogenic inflammatory bowel disease MRE11 Louise Daugherty reviewed MRE11
Primary immunodeficiency or monogenic inflammatory bowel disease MRE11 Louise Daugherty Added gene to panel
Primary immunodeficiency or monogenic inflammatory bowel disease MRE11 Louise Daugherty Added gene to panel