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Primary immunodeficiency or monogenic inflammatory bowel disease v2.577 UBA1 Dmitrijs Rots commented on gene: UBA1: NRAS and KRAS SOMATIC variants are included as Amber in this panel
Primary immunodeficiency or monogenic inflammatory bowel disease v1.137 NRAS Louise Daugherty commented on gene: NRAS: Gene was flagged as requiring further clinical input from the Immunology Test Group, but no additional information was submitted to support the Green rating. In view of a lack of clear evidence the current recommendation is Amber.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.130 NRAS Louise Daugherty commented on gene: NRAS: Noonan (plus malignancies in somatic variants): ?relevant phenotype
Primary immunodeficiency or monogenic inflammatory bowel disease v1.101 NRAS Louise Daugherty commented on gene: NRAS: This is a relevant phenotype but there is not enough evidence in the literature to date (PMID: 17517660 seems to report one person with NRAS and this phenotype) and there has been no further evidence in terms of unpublished cases other than a Green rating recommendation from the Immunology Specialist Test Group. To remain Amber unless further supporting evidence from the Test Group.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.101 NRAS Louise Daugherty edited their review of gene: NRAS: Changed rating: AMBER
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 NRAS Louise Daugherty commented on gene: NRAS: Gene rating submitted by Kimberly Gilmour and Austen Worth on behalf of London North GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email 6th September the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 NRAS Louise Daugherty edited their review of gene: NRAS: Added comment: Gene rating submitted by Tracy Briggs, David Gokhale and Abigal Rousseau on behalf of North West GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email on 20th June the Specialist Test Group all agreed there is enough evidence to rate this gene Green.; Changed rating: GREEN
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 NRAS Kimberly Gilmour reviewed gene: NRAS: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 NRAS Tracy Briggs reviewed gene: NRAS: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.60 NRAS Louise Daugherty Source NHS GMS was added to NRAS.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.59 NRAS Louise Daugherty Source North West GLH was added to NRAS.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.58 NRAS Louise Daugherty Source London North GLH was added to NRAS.
Primary immunodeficiency or monogenic inflammatory bowel disease NRAS Louise Daugherty marked gene: NRAS as ready
Primary immunodeficiency or monogenic inflammatory bowel disease NRAS Sophie Hambleton reviewed gene: NRAS
Primary immunodeficiency or monogenic inflammatory bowel disease NRAS Sarah Leigh classified NRAS as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease NRAS Louise Daugherty commented on NRAS
Primary immunodeficiency or monogenic inflammatory bowel disease NRAS Louise Daugherty commented on NRAS
Primary immunodeficiency or monogenic inflammatory bowel disease NRAS Louise Daugherty commented on NRAS
Primary immunodeficiency or monogenic inflammatory bowel disease NRAS Louise Daugherty reviewed NRAS
Primary immunodeficiency or monogenic inflammatory bowel disease NRAS Louise Daugherty Added gene to panel