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Primary immunodeficiency or monogenic inflammatory bowel disease v2.317 STK4 Eleanor Williams Classified gene: STK4 as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.317 STK4 Eleanor Williams Added comment: Comment on list classification: Changed rating of gene from Red to Green. This gene was rated as Green in v2.208 and incorrectly automatically demoted to Red in v2.209. This was due to a defect in the automatic PanelApp uploading tool when a set of publications was added to the panel with the source ‘Other’, and under certain conditions associated to previous sources listed, resulted in the rating of the gene being automatically changed when it should not have been.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.317 STK4 Eleanor Williams Gene: stk4 has been classified as Green List (High Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.209 STK4 Eleanor Williams Source Other was added to STK4.
Publications for gene STK4 were updated from 22174160; 22294732; 26801501; 26117625; 24453252 to 22294732; 26801501; 24453252; 26117625; 22174160
Rating Changed from Green List (high evidence) to Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.208 STK4 Eleanor Williams reviewed gene: STK4: Rating: ; Mode of pathogenicity: ; Publications: 22174160, 26801501, 26117625, 22294732; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v2.197 STK4 Eleanor Williams Phenotypes for gene: STK4 were changed from Hypergammaglobulinaemia, lymphopenia, combined immunodeficiency, congenital heart disease, autoimmunity; T-cell immunodeficiency, recurrent infections, autoimmunity, and cardiac malformations; AR hyperimmunoglobulin E syndrome; Combined immunodeficiency; Intermittent neutropenia, bacterial, viral (HPV), candidal infections, EBV lymphoproliferation, autoimmune cytopenias, lymphoma, congenital heart disease; Immunodeficiencies affecting cellular and humoral immunity to Hypergammaglobulinaemia, lymphopenia, combined immunodeficiency, congenital heart disease, autoimmunity; T-cell immunodeficiency, recurrent infections, autoimmunity, and cardiac malformations, 614868; AR hyperimmunoglobulin E syndrome; Combined immunodeficiency; Intermittent neutropenia, bacterial, viral (HPV), candidal infections, EBV lymphoproliferation, autoimmune cytopenias, lymphoma, congenital heart disease; Immunodeficiencies affecting cellular and humoral immunity
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 STK4 Louise Daugherty commented on gene: STK4: Gene rating submitted by Kimberly Gilmour and Austen Worth on behalf of London North GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email 6th September the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 STK4 Louise Daugherty commented on gene: STK4: Gene rating submitted by Tracy Briggs, David Gokhale and Abigal Rousseau on behalf of North West GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email on 20th June the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 STK4 Kimberly Gilmour reviewed gene: STK4: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 STK4 Tracy Briggs reviewed gene: STK4: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.60 STK4 Louise Daugherty Source NHS GMS was added to STK4.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.59 STK4 Louise Daugherty Source North West GLH was added to STK4.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.58 STK4 Louise Daugherty Source London North GLH was added to STK4.
Primary immunodeficiency or monogenic inflammatory bowel disease STK4 Louise Daugherty commented on gene: STK4
Primary immunodeficiency or monogenic inflammatory bowel disease STK4 Louise Daugherty marked gene: STK4 as ready
Primary immunodeficiency or monogenic inflammatory bowel disease STK4 Sophie Hambleton reviewed gene: STK4
Primary immunodeficiency or monogenic inflammatory bowel disease STK4 Louise Daugherty edited their review of STK4
Primary immunodeficiency or monogenic inflammatory bowel disease STK4 Louise Daugherty commented on STK4
Primary immunodeficiency or monogenic inflammatory bowel disease STK4 Louise Daugherty commented on STK4
Primary immunodeficiency or monogenic inflammatory bowel disease STK4 Louise Daugherty reviewed STK4
Primary immunodeficiency or monogenic inflammatory bowel disease STK4 Louise Daugherty Added gene to panel