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Primary immunodeficiency or monogenic inflammatory bowel disease v2.529 TOP2B Arina Puzriakova Tag for-review was removed from gene: TOP2B.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.529 TOP2B Arina Puzriakova commented on gene: TOP2B: The rating of this gene has been updated following NHS Genomic Medicine Service approval.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.528 TOP2B Arina Puzriakova Source Expert Review Green was added to TOP2B.
Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.362 TOP2B Arina Puzriakova Classified gene: TOP2B as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.362 TOP2B Arina Puzriakova Added comment: Comment on list classification: Changed rating from Green to Amber so that Green genes on this panel reflect the NHS signed-off version. This will be reviewed at the next GMS panel update (added 'for-review' tag).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.362 TOP2B Arina Puzriakova Gene: top2b has been classified as Amber List (Moderate Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.361 TOP2B Arina Puzriakova Tag for-review tag was added to gene: TOP2B.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.74 TOP2B Ivone Leong Classified gene: TOP2B as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.74 TOP2B Ivone Leong Added comment: Comment on list classification: Promoted from Red to Green based on expert review and evidence.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.74 TOP2B Ivone Leong Gene: top2b has been classified as Green List (High Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.51 TOP2B Zornitza Stark reviewed gene: TOP2B: Rating: GREEN; Mode of pathogenicity: None; Publications: 31409799; Phenotypes: Antibody deficiency, Recurrent infections, Facial dysmorphism, Limb anomalies; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Primary immunodeficiency or monogenic inflammatory bowel disease v2.36 TOP2B Louise Daugherty reviewed gene: TOP2B: Rating: AMBER; Mode of pathogenicity: ; Publications: 31409799; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v2.35 TOP2B Louise Daugherty Publications for gene TOP2B were updated from 32048120; 32086639 to 31409799; 32086639; 32048120
Primary immunodeficiency or monogenic inflammatory bowel disease v2.13 TOP2B Louise Daugherty gene: TOP2B was added
gene: TOP2B was added to Primary immunodeficiency. Sources: IUIS Classification December 2019
Mode of inheritance for gene: TOP2B was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Publications for gene: TOP2B were set to 32048120; 32086639
Phenotypes for gene: TOP2B were set to Recurrent infections, facial dysmorphism, limb anomalies; Predominantly Antibody Deficiencies; Hoffman syndrome/TOP2B deficiency