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Primary immunodeficiency or monogenic inflammatory bowel disease v2.333 ZAP70 Eleanor Williams Classified gene: ZAP70 as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.333 ZAP70 Eleanor Williams Added comment: Comment on list classification: Changed rating of gene from Red to Green. This gene was rated as Green in v2.208 and incorrectly automatically demoted to Red in v2.209. This was due to a defect in the automatic PanelApp uploading tool when a set of publications was added to the panel with the source ‘Other’, and under certain conditions associated to previous sources listed, resulted in the rating of the gene being automatically changed when it should not have been.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.333 ZAP70 Eleanor Williams Gene: zap70 has been classified as Green List (High Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.209 ZAP70 Eleanor Williams Publications for gene ZAP70 were updated from 8202713; 19548248; 18509675; 26783323; 25732729; 25805655 to 1333922; 8202713; 19548248; 21094993; 18509675; 26783323; 2511270; 25732729; 8124727; 25805655
Primary immunodeficiency or monogenic inflammatory bowel disease v2.209 ZAP70 Eleanor Williams Source Other was added to ZAP70.
Publications for gene ZAP70 were updated from to 8202713; 19548248; 18509675; 26783323; 25732729; 25805655
Rating Changed from Green List (high evidence) to Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.208 ZAP70 Eleanor Williams edited their review of gene: ZAP70: Added comment: The following PubMed IDs were added to gene ZAP70 (OMIM gene MIM#176947): 19548248;18509675;8202713;26783323;25805655;25732729. These publications have been associated with the gene by the immunedysregulation subgroup of the Human Phenotype Ontology Immune Mediated Disorders Consortium (https://hpo-immune-mediated-disorders.groups.io/g/update) in August 2020.; Changed publications: 19548248, 18509675, 8202713, 26783323, 25805655, 25732729
Primary immunodeficiency or monogenic inflammatory bowel disease v2.207 ZAP70 Eleanor Williams reviewed gene: ZAP70: Rating: ; Mode of pathogenicity: ; Publications: 18509675, 26783323, 1333922, 21094993, 8124727, 2511270; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 ZAP70 Louise Daugherty commented on gene: ZAP70: Gene rating submitted by Kimberly Gilmour and Austen Worth on behalf of London North GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email 6th September the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 ZAP70 Louise Daugherty commented on gene: ZAP70: Gene rating submitted by Tracy Briggs, David Gokhale and Abigal Rousseau on behalf of North West GLH for the GMS Immunology specialist test group. As discussed with the GMS Immunology Specialist Test Group during webex call 28th March 2019 and confirmed in follow up email on 20th June the Specialist Test Group all agreed there is enough evidence to rate this gene Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 ZAP70 Kimberly Gilmour commented on gene: ZAP70: agree with green gene
Primary immunodeficiency or monogenic inflammatory bowel disease v1.94 ZAP70 Tracy Briggs reviewed gene: ZAP70: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v1.60 ZAP70 Louise Daugherty Source NHS GMS was added to ZAP70.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.59 ZAP70 Louise Daugherty Source North West GLH was added to ZAP70.
Primary immunodeficiency or monogenic inflammatory bowel disease v1.58 ZAP70 Louise Daugherty Source London North GLH was added to ZAP70.
Primary immunodeficiency or monogenic inflammatory bowel disease ZAP70 Louise Daugherty commented on gene: ZAP70
Primary immunodeficiency or monogenic inflammatory bowel disease ZAP70 Louise Daugherty marked gene: ZAP70 as ready
Primary immunodeficiency or monogenic inflammatory bowel disease ZAP70 Louise Daugherty commented on ZAP70
Primary immunodeficiency or monogenic inflammatory bowel disease ZAP70 Louise Daugherty commented on ZAP70
Primary immunodeficiency or monogenic inflammatory bowel disease ZAP70 Louise Daugherty reviewed ZAP70
Primary immunodeficiency or monogenic inflammatory bowel disease ZAP70 Louise Daugherty Added gene to panel