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Date	Panel	Item	Activity
Filter activities 19 actions
09 Mar 2022	Hereditary ataxia with onset in adulthood v2.144	CLP1	Eleanor Williams Tag Q2_21_phenotype was removed from gene: CLP1.
09 Mar 2022	Hereditary ataxia with onset in adulthood v2.144	CLP1	Sarah Leigh commented on gene: CLP1: The rating of this gene has been updated following NHS Genomic Medicine Service approval.
09 Mar 2022	Hereditary ataxia with onset in adulthood v2.143	CLP1	Eleanor Williams Source Expert Review Amber was added to CLP1. Rating Changed from Green List (high evidence) to Amber List (moderate evidence)
16 Feb 2021	Hereditary ataxia with onset in adulthood v2.23	CLP1	Sarah Leigh changed review comment from: Zornitza Stark has reviewed this gene as red on this panel, as the phenotype associated with variants in CLP1 is evident in childhood. Furthermore, only a single Founder variant has been reported, in patients.; to: Zornitza Stark has reviewed this gene as red on this panel, as the phenotype associated with variants in CLP1 is evident in childhood. Furthermore, only a single (founder) variant has been reported, in patients.
16 Feb 2021	Hereditary ataxia with onset in adulthood v2.23	CLP1	Sarah Leigh Phenotypes for gene: CLP1 were changed from Pontocerebellar hypoplasia type 10, 615803 to Pontocerebellar hypoplasia type 10 OMIM:615803
16 Feb 2021	Hereditary ataxia with onset in adulthood v2.22	CLP1	Sarah Leigh Publications for gene: CLP1 were set to
16 Feb 2021	Hereditary ataxia with onset in adulthood v2.21	CLP1	Sarah Leigh Tag founder-effect tag was added to gene: CLP1.
16 Feb 2021	Hereditary ataxia with onset in adulthood v2.21	CLP1	Sarah Leigh reviewed gene: CLP1: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None
16 Feb 2021	Hereditary ataxia with onset in adulthood v2.21	CLP1	Sarah Leigh Tag Q2_21_phenotype tag was added to gene: CLP1.
14 Feb 2021	Hereditary ataxia with onset in adulthood v2.21	CLP1	Zornitza Stark reviewed gene: CLP1: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: Pontocerebellar hypoplasia type 10, 615803; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
27 Apr 2019	Hereditary ataxia with onset in adulthood v1.60	CLP1	Louise Daugherty Phenotypes for gene: CLP1 were changed from Pontocerebellar hypoplasia type 10, 615803; Pontocerebellar hypoplasia 10 (#615803) to Pontocerebellar hypoplasia type 10, 615803
27 Apr 2019	Hereditary ataxia with onset in adulthood v1.59	CLP1	Louise Daugherty Classified gene: CLP1 as Green List (high evidence)
27 Apr 2019	Hereditary ataxia with onset in adulthood v1.59	CLP1	Louise Daugherty Gene: clp1 has been classified as Green List (High Evidence).
15 Apr 2019	Hereditary ataxia with onset in adulthood v1.9	CLP1	Louise Daugherty Added phenotypes Pontocerebellar hypoplasia type 10, 615803 for gene: CLP1
15 Apr 2019	Hereditary ataxia with onset in adulthood v1.8	CLP1	Louise Daugherty reviewed gene: CLP1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
15 Apr 2019	Hereditary ataxia with onset in adulthood v1.7	CLP1	Tracy Lester reviewed gene: CLP1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: Pontocerebellar hypoplasia type 10, 615803; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
14 Apr 2019	Hereditary ataxia with onset in adulthood v1.2	CLP1	Louise Daugherty Source NHS GMS was added to CLP1.
14 Apr 2019	Hereditary ataxia with onset in adulthood v1.1	CLP1	Louise Daugherty Source Wessex and West Midlands GLH was added to CLP1.
15 Dec 2018	Hereditary ataxia with onset in adulthood v0.2	CLP1	Eleanor Williams gene: CLP1 was added gene: CLP1 was added to Hereditary ataxia - adult onset. Sources: Hereditary ataxia v1.148,Expert Review Red Mode of inheritance for gene: CLP1 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: CLP1 were set to Pontocerebellar hypoplasia 10 (#615803)