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Neurodegenerative disorders - adult onset v1.101 DNMT1 Louise Daugherty commented on gene: DNMT1: Review and rating from Tracy Lester (Oxford Medical Genetics Laboratories Oxford University Hospitals NHS Foundation Trust) on behalf of Wessex and West Midlands GLH for GMS Neurology specialist test group. All the green and amber, except for the genes with triplet repeats, were reviewed.
Neurodegenerative disorders - adult onset v1.100 DNMT1 Louise Daugherty Source Wessex and West Midlands GLH was added to DNMT1.
Neurodegenerative disorders - adult onset v1.99 DNMT1 Tracy Lester reviewed gene: DNMT1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: Dementia, Deafness, and Sensory Neuropathy, Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant,; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Neurodegenerative disorders - adult onset v1.81 DNMT1 Louise Daugherty Publications for gene DNMT1 were changed from 23365052 to 23365052; 8747854; 22328086
Neurodegenerative disorders - adult onset v1.74 DNMT1 Louise Daugherty commented on gene: DNMT1: Review and rating submitted by Nick Beauchamp (Sheffield Diagnostic genetics Service), on behalf of Yorkshire and North East GLH for GMS Neurology specialist test group.
Neurodegenerative disorders - adult onset v1.72 DNMT1 Nick Beauchamp reviewed gene: DNMT1: Rating: GREEN; Mode of pathogenicity: ; Publications: 22328086, 8747854; Phenotypes: Dementia, Deafness, and Sensory Neuropathy, Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown; Current diagnostic: yes
Neurodegenerative disorders - adult onset v1.67 DNMT1 Louise Daugherty Source Yorkshire and North East GLH was added to DNMT1.
Neurodegenerative disorders - adult onset v1.11 DNMT1 Louise Daugherty reviewed gene: DNMT1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Neurodegenerative disorders - adult onset v1.10 DNMT1 James Polke reviewed gene: DNMT1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes
Neurodegenerative disorders - adult onset v1.9 DNMT1 Louise Daugherty Source NHS GMS was added to DNMT1.
Neurodegenerative disorders - adult onset v1.8 DNMT1 Louise Daugherty Source London North GLH was added to DNMT1.
Neurodegenerative disorders - adult onset v0.2 DNMT1 Rebecca Foulger Added phenotypes Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant, for gene: DNMT1
Neurodegenerative disorders - adult onset v0.2 DNMT1 Rebecca Foulger gene: DNMT1 was added
gene: DNMT1 was added to Neurodegenerative disorders - adult onset. Sources: Expert Review Green
Mode of inheritance for gene: DNMT1 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Publications for gene: DNMT1 were set to 23365052
Phenotypes for gene: DNMT1 were set to Dementia, Deafness, and Sensory Neuropathy