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| Pituitary hormone deficiency v2.106 | TCF7L1 |
Catherine Snow Tag Q3_22_rating was removed from gene: TCF7L1. Tag Q3_22_NHS_review was removed from gene: TCF7L1. |
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| Pituitary hormone deficiency v2.106 | TCF7L1 | Catherine Snow changed review comment from: After NHS Genomic Medicine Service consideration, the rating of this gene has not been changed and remainsAMBER. The additional comments from GLH's is "Insufficient evidence, sugget amber rating pending further evidence."; to: After NHS Genomic Medicine Service consideration, the rating of this gene has not been changed and remains AMBER. The additional comments from GLH's is "Insufficient evidence, suggest amber rating pending further evidence." | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pituitary hormone deficiency v2.106 | TCF7L1 | Catherine Snow commented on gene: TCF7L1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pituitary hormone deficiency v2.80 | TCF7L1 |
Sarah Leigh Tag Q3_22_rating tag was added to gene: TCF7L1. Tag Q3_22_NHS_review tag was added to gene: TCF7L1. |
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| Pituitary hormone deficiency v2.80 | TCF7L1 | Sarah Leigh reviewed gene: TCF7L1: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pituitary hormone deficiency v2.15 | TCF7L1 | Eleanor Williams reviewed gene: TCF7L1: Rating: ; Mode of pathogenicity: ; Publications: 26764381; Phenotypes: SEPTO-OPTIC DYSPLASIA; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pituitary hormone deficiency v0.65 | TCF7L1 | Ivone Leong Marked gene: TCF7L1 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pituitary hormone deficiency v0.65 | TCF7L1 | Ivone Leong Gene: tcf7l1 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pituitary hormone deficiency v0.32 | TCF7L1 | Ivone Leong Classified gene: TCF7L1 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pituitary hormone deficiency v0.32 | TCF7L1 | Ivone Leong Added comment: Comment on list classification: Promoted from red to amber. TCF7L1 is not associated with any phenotypes in OMIM or Gene2Phenotype. There is one study reporting a patient with septo-optic dysplasia with a missense variant in TCF7L1 who also has growth hormone deficiency. In vitro studies support that this variant reduced TCF7L1 protein function. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pituitary hormone deficiency v0.32 | TCF7L1 | Ivone Leong Gene: tcf7l1 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pituitary hormone deficiency v0.31 | TCF7L1 | Ivone Leong Phenotypes for gene: TCF7L1 were changed from No OMIM number to No OMIM number; pituitary hormone deficiency | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pituitary hormone deficiency v0.30 | TCF7L1 | Ivone Leong Mode of inheritance for gene: TCF7L1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pituitary hormone deficiency v0.29 | TCF7L1 | Ivone Leong Publications for gene: TCF7L1 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pituitary hormone deficiency v0.5 | TCF7L1 |
Ivone Leong gene: TCF7L1 was added gene: TCF7L1 was added to Pituitary hormone deficiency. Sources: Literature Mode of inheritance for gene: TCF7L1 was set to Unknown Phenotypes for gene: TCF7L1 were set to No OMIM number |
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