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Laterality disorders and isomerism v2.3 TTC25 Sarah Leigh Tag Q3_22_rating was removed from gene: TTC25.
Laterality disorders and isomerism v2.3 TTC25 Sarah Leigh reviewed gene: TTC25: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Laterality disorders and isomerism v2.2 TTC25 Sarah Leigh Source Expert Review Green was added to TTC25.
Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Laterality disorders and isomerism v1.50 TTC25 Arina Puzriakova Phenotypes for gene: TTC25 were changed from Ciliary dyskinesia, primary, 35, 617092 to Ciliary dyskinesia, primary, 35, OMIM:617092
Laterality disorders and isomerism v1.49 TTC25 Arina Puzriakova Publications for gene: TTC25 were set to 27486780
Laterality disorders and isomerism v1.48 TTC25 Arina Puzriakova Classified gene: TTC25 as Amber List (moderate evidence)
Laterality disorders and isomerism v1.48 TTC25 Arina Puzriakova Added comment: Comment on list classification: Biallelic variants cause a primary ciliary dyskinesia which is associated with laterality defects - at least 6 unrelated families reported in literature (PMID: 27486780; 33715250; 33746037; 34215651)
This evidence now supports a Green rating on this panel and so this gene should be updated accordingly at the next GMS panel update.
Laterality disorders and isomerism v1.48 TTC25 Arina Puzriakova Gene: ttc25 has been classified as Amber List (Moderate Evidence).
Laterality disorders and isomerism v1.47 TTC25 Arina Puzriakova Tag Q3_22_rating tag was added to gene: TTC25.
Laterality disorders and isomerism v1.21 TTC25 Catherine Snow Tag new-gene-name tag was added to gene: TTC25.
Laterality disorders and isomerism v1.21 TTC25 Catherine Snow commented on gene: TTC25
Laterality disorders and isomerism v0.135 TTC25 Louise Daugherty Classified gene: TTC25 as Amber List (moderate evidence)
Laterality disorders and isomerism v0.135 TTC25 Louise Daugherty Added comment: Comment on list classification: Downgraded from Green to Amber after expert review. Change of rating will be included in update with Test Group to enable further comment/review if required before sign off.
Laterality disorders and isomerism v0.135 TTC25 Louise Daugherty Gene: ttc25 has been classified as Amber List (Moderate Evidence).
Laterality disorders and isomerism v0.121 TTC25 Louise Daugherty Phenotypes for gene: TTC25 were changed from to Ciliary dyskinesia, primary, 35, 617092
Laterality disorders and isomerism v0.120 TTC25 Louise Daugherty Publications for gene: TTC25 were set to
Laterality disorders and isomerism v0.119 TTC25 Louise Daugherty Mode of inheritance for gene: TTC25 was changed from to BIALLELIC, autosomal or pseudoautosomal
Laterality disorders and isomerism v0.51 TTC25 Matthew Edwards reviewed gene: TTC25: Rating: AMBER; Mode of pathogenicity: None; Publications: 27486780; Phenotypes: OMIM 617092 Ciliary dyskinesia, primary, 35; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
Laterality disorders and isomerism v0.20 TTC25 Louise Daugherty commented on gene: TTC25: From GMS Respiratory Specialist Test Group webex call 18th Jan 2019 : there are unpublished cases and functional evidence to support this gene to be rated as Green.
Laterality disorders and isomerism v0.3 TTC25 Louise Daugherty Source Expert Review Green was added to TTC25.
Rating Changed from Red List (low evidence) to Green List (high evidence)
Laterality disorders and isomerism v0.2 TTC25 Louise Daugherty reviewed gene: TTC25: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Laterality disorders and isomerism v0.1 TTC25 Louise Daugherty gene: TTC25 was added
gene: TTC25 was added to Laterality disorders and isomerism. Sources: NHS GMS
Mode of inheritance for gene: TTC25 was set to