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Laterality disorders and isomerism v2.3 | TTC25 | Sarah Leigh Tag Q3_22_rating was removed from gene: TTC25. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v2.3 | TTC25 | Sarah Leigh reviewed gene: TTC25: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v2.2 | TTC25 |
Sarah Leigh Source Expert Review Green was added to TTC25. Rating Changed from Amber List (moderate evidence) to Green List (high evidence) |
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Laterality disorders and isomerism v1.50 | TTC25 | Arina Puzriakova Phenotypes for gene: TTC25 were changed from Ciliary dyskinesia, primary, 35, 617092 to Ciliary dyskinesia, primary, 35, OMIM:617092 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v1.49 | TTC25 | Arina Puzriakova Publications for gene: TTC25 were set to 27486780 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v1.48 | TTC25 | Arina Puzriakova Classified gene: TTC25 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v1.48 | TTC25 |
Arina Puzriakova Added comment: Comment on list classification: Biallelic variants cause a primary ciliary dyskinesia which is associated with laterality defects - at least 6 unrelated families reported in literature (PMID: 27486780; 33715250; 33746037; 34215651) This evidence now supports a Green rating on this panel and so this gene should be updated accordingly at the next GMS panel update. |
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Laterality disorders and isomerism v1.48 | TTC25 | Arina Puzriakova Gene: ttc25 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v1.47 | TTC25 | Arina Puzriakova Tag Q3_22_rating tag was added to gene: TTC25. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v1.21 | TTC25 | Catherine Snow Tag new-gene-name tag was added to gene: TTC25. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v1.21 | TTC25 | Catherine Snow commented on gene: TTC25 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v0.135 | TTC25 | Louise Daugherty Classified gene: TTC25 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v0.135 | TTC25 | Louise Daugherty Added comment: Comment on list classification: Downgraded from Green to Amber after expert review. Change of rating will be included in update with Test Group to enable further comment/review if required before sign off. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v0.135 | TTC25 | Louise Daugherty Gene: ttc25 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v0.121 | TTC25 | Louise Daugherty Phenotypes for gene: TTC25 were changed from to Ciliary dyskinesia, primary, 35, 617092 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v0.120 | TTC25 | Louise Daugherty Publications for gene: TTC25 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v0.119 | TTC25 | Louise Daugherty Mode of inheritance for gene: TTC25 was changed from to BIALLELIC, autosomal or pseudoautosomal | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v0.51 | TTC25 | Matthew Edwards reviewed gene: TTC25: Rating: AMBER; Mode of pathogenicity: None; Publications: 27486780; Phenotypes: OMIM 617092 Ciliary dyskinesia, primary, 35; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v0.20 | TTC25 | Louise Daugherty commented on gene: TTC25: From GMS Respiratory Specialist Test Group webex call 18th Jan 2019 : there are unpublished cases and functional evidence to support this gene to be rated as Green. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v0.3 | TTC25 |
Louise Daugherty Source Expert Review Green was added to TTC25. Rating Changed from Red List (low evidence) to Green List (high evidence) |
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Laterality disorders and isomerism v0.2 | TTC25 | Louise Daugherty reviewed gene: TTC25: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Laterality disorders and isomerism v0.1 | TTC25 |
Louise Daugherty gene: TTC25 was added gene: TTC25 was added to Laterality disorders and isomerism. Sources: NHS GMS Mode of inheritance for gene: TTC25 was set to |