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Vascular skin disorders v1.57 | FLT4 | Arina Puzriakova Classified gene: FLT4 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vascular skin disorders v1.57 | FLT4 |
Arina Puzriakova Added comment: Comment on list classification: Inclusion of FLT4 should be reviewed by the GMS specialist team due to conflicting reviews. Primary lymphoedema caused by heterozygous variants in this gene does not fit the panel scope and is more appropriate for R136 Primary lymphoedema. Since 2002, there has only been one report of a somatic variant causing skin capillary haemangiomas (PMID:11807987). There has been no evidence of germline variants causing a similar phenotype. |
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Vascular skin disorders v1.57 | FLT4 | Arina Puzriakova Gene: flt4 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vascular skin disorders v1.56 | FLT4 |
Arina Puzriakova Tag somatic tag was added to gene: FLT4. Tag Q1_24_demote_red tag was added to gene: FLT4. Tag Q1_24_expert_review tag was added to gene: FLT4. |
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Vascular skin disorders v1.23 | FLT4 |
Ivone Leong Added comment: Comment on phenotypes: Previous phenotypes: Infantile haemangioma;Milroy disease |
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Vascular skin disorders v1.23 | FLT4 | Ivone Leong Phenotypes for gene: FLT4 were changed from Infantile haemangioma; Milroy disease to Hemangioma, capillary infantile, somatic, OMIM:602089 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vascular skin disorders v1.22 | FLT4 | Ivone Leong Publications for gene: FLT4 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vascular skin disorders v1.3 | FLT4 | Zornitza Stark reviewed gene: FLT4: Rating: RED; Mode of pathogenicity: None; Publications: 11807987; Phenotypes: Hemangioma, capillary infantile, somatic, MIM# 602089; Mode of inheritance: None | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vascular skin disorders v0.24 | FLT4 | Tom Cullup reviewed gene: FLT4: Rating: GREEN; Mode of pathogenicity: ; Publications: 10835628, 11807987; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vascular skin disorders v0.5 | FLT4 | Rebecca Foulger Source London North GLH was added to FLT4. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vascular skin disorders v0.4 | FLT4 | Rebecca Foulger reviewed gene: FLT4: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vascular skin disorders v0.3 | FLT4 |
Rebecca Foulger gene: FLT4 was added gene: FLT4 was added to Vascular skin disorders. Sources: Expert Review Green,NHS GMS Mode of inheritance for gene: FLT4 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: FLT4 were set to Infantile haemangioma; Milroy disease |