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06 Sep 2019	Childhood onset hereditary spastic paraplegia v1.178	MARS	Louise Daugherty Tag new-gene-name tag was added to gene: MARS.
06 Sep 2019	Childhood onset hereditary spastic paraplegia v1.178	MARS	Louise Daugherty commented on gene: MARS
21 May 2019	Childhood onset hereditary spastic paraplegia v1.166	MARS2	Louise Daugherty commented on gene: MARS2: Amber gene with Green GLH rating, Gene discussed in view of discrepant rating(s) from GLH(s). Amber rating agreed at the GMS Neurology Specialist Test Group Webex on 17th May 2019.
13 May 2019	Childhood onset hereditary spastic paraplegia v1.120	MARS2	Louise Daugherty Publications for gene: MARS2 were set to
13 May 2019	Childhood onset hereditary spastic paraplegia v1.119	MARS2	Louise Daugherty Mode of inheritance for gene: MARS2 was changed from to BIALLELIC, autosomal or pseudoautosomal
13 May 2019	Childhood onset hereditary spastic paraplegia v1.81	MARS	Louise Daugherty Publications for gene: MARS were set to Novarino et al. (2014)
13 May 2019	Childhood onset hereditary spastic paraplegia v1.76	MARS	Louise Daugherty Source NHS GMS was added to MARS.
13 May 2019	Childhood onset hereditary spastic paraplegia v1.75	MARS2	Louise Daugherty Source Yorkshire and North East GLH was added to MARS2.
13 May 2019	Childhood onset hereditary spastic paraplegia v1.75	MARS	Louise Daugherty Source Yorkshire and North East GLH was added to MARS.
10 May 2019	Childhood onset hereditary spastic paraplegia v1.74	MARS	Nick Beauchamp reviewed gene: MARS: Rating: RED; Mode of pathogenicity: None; Publications: 24482476; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
10 May 2019	Childhood onset hereditary spastic paraplegia v1.74	MARS2	Nick Beauchamp reviewed gene: MARS2: Rating: GREEN; Mode of pathogenicity: None; Publications: 22448145; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
09 May 2019	Childhood onset hereditary spastic paraplegia v1.74	MARS2	Louise Daugherty commented on gene: MARS2: Rating and review submitted on behalf of James Polke (Neurogenetics Laboratory,Institute of Neurology, London), on behalf of London North GLH for GMS Neurology specialist test group.
02 May 2019	Childhood onset hereditary spastic paraplegia v1.61	MARS2	Louise Daugherty Classified gene: MARS2 as Amber List (moderate evidence)
02 May 2019	Childhood onset hereditary spastic paraplegia v1.61	MARS2	Louise Daugherty Gene: mars2 has been classified as Amber List (Moderate Evidence).
02 May 2019	Childhood onset hereditary spastic paraplegia v1.60	MARS2	Louise Daugherty commented on gene: MARS2: Amber rating on Hereditary spastic paraplegia panel 1.198 Bayat (2012, 22448145) Approx 300b deletion /?duplication/rearrangement, Complex genomic MARS2 rearrangements identified in 54 affected French-Canadian cases belonging to 38 families with a mean age of onset of 24.4 (2–59). Lots of in vivo studies. No HGMD/Pubmed reports of MARS2 rearrangements since this paper, but probably inst being widely tested and if so, large rearrangements aren't particularly amenable to ngs Chris Buxton (North Bristol NHS Trust), 27 Nov 2018 Submitted Green review. helen kingston (CMFT NHS Foundation Trust, Manchester) Submitted Green review.
28 Apr 2019	Childhood onset hereditary spastic paraplegia v1.48	MARS2	Louise Daugherty reviewed gene: MARS2: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
28 Apr 2019	Childhood onset hereditary spastic paraplegia v1.25	MARS2	Louise Daugherty Phenotypes for gene: MARS2 were changed from Spastic ataxia 3, autosomal recessive to Spastic ataxia 3, autosomal recessive, 611390
28 Apr 2019	Childhood onset hereditary spastic paraplegia v1.24	MARS2	Louise Daugherty Classified gene: MARS2 as Green List (high evidence)
28 Apr 2019	Childhood onset hereditary spastic paraplegia v1.24	MARS2	Louise Daugherty Gene: mars2 has been classified as Green List (High Evidence).
28 Apr 2019	Childhood onset hereditary spastic paraplegia v1.6	MARS2	James Polke reviewed gene: MARS2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: Spastic ataxia 3, autosomal recessive, 611390; Mode of inheritance:
28 Apr 2019	Childhood onset hereditary spastic paraplegia v1.5	MARS2	Louise Daugherty Source NHS GMS was added to MARS2.
28 Apr 2019	Childhood onset hereditary spastic paraplegia v1.4	MARS2	Louise Daugherty Source London North GLH was added to MARS2.
03 Apr 2019	Childhood onset hereditary spastic paraplegia v1.3	MARS2	Louise Daugherty Added phenotypes Spastic ataxia 3, autosomal recessive for gene: MARS2
19 Dec 2018	Childhood onset hereditary spastic paraplegia v0.6	MARS2	Sarah Leigh gene: MARS2 was added gene: MARS2 was added to Hereditary spastic paraplegia - childhood onset. Sources: Radboud University Medical Center, Nijmegen,Expert Review Red Mode of inheritance for gene: MARS2 was set to Phenotypes for gene: MARS2 were set to Spastic ataxia 3, autosomal recessive
19 Dec 2018	Childhood onset hereditary spastic paraplegia v0.6	MARS	Sarah Leigh gene: MARS was added gene: MARS was added to Hereditary spastic paraplegia - childhood onset. Sources: Expert list,Expert Review Red Mode of inheritance for gene: MARS was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: MARS were set to Novarino et al. (2014)