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Long QT syndrome v1.48 CALM1 Ivone Leong Source Expert Review Green was added to CALM1.
Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Long QT syndrome v1.47 CALM1 Kate Thomson reviewed gene: CALM1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Long QT syndrome v1.44 CALM1 Ivone Leong reviewed gene: CALM1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Long QT syndrome v1.38 CALM1 Matthew Edwards changed review comment from: Gene on Royal Brompton LQTS panel, but low evidence for this (although some evidence for de novo variant assoc. with LQTS/VT phenotype). Definitive for CPVT. Happy woth Amber on LQTS panel; to: On CGGL Royal Brompton LQTS panel, but low evidence for this (although some evidence for de novo variant assoc. with LQTS/VT phenotype). Definitive for CPVT. Happy with Amber on LQTS panel
Long QT syndrome v1.26 CALM1 Rebecca Whittington commented on gene: CALM1: Long QT syndrome 14 (OMIM 616247).Ventricular tachycardia, catecholaminergic polymorphic, 4 (OMIM 614916).
Long QT syndrome v1.25 CALM1 Rebecca Whittington commented on gene: CALM1: Evidence associated with CPVT primarily. Reported de novo variant in 6 year old boy (PMID: 28491771) with LQT but phenotype not clear (need clinical input). Other paper with strong de novo CALM1 variant in child with LQT and cardiac arrest (PMID:27374306). PMID 23388215.
Long QT syndrome v1.24 CALM1 Rebecca Whittington reviewed gene: CALM1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes
Long QT syndrome v1.23 CALM1 Matthew Edwards reviewed gene: CALM1: Rating: AMBER; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None
Long QT syndrome v1.18 CALM1 Ellen McDonagh Classified gene: CALM1 as Amber List (moderate evidence)
Long QT syndrome v1.18 CALM1 Ellen McDonagh Added comment: Comment on list classification: It was decided in the NHSE GMS Cardiology Specialist Group meeting call on 25th January 2019 to promote this gene from Red to Amber on this panel.
Long QT syndrome v1.18 CALM1 Ellen McDonagh Gene: calm1 has been classified as Amber List (Moderate Evidence).
Long QT syndrome v1.17 CALM1 Ellen McDonagh Classified gene: CALM1 as Amber List (moderate evidence)
Long QT syndrome v1.17 CALM1 Ellen McDonagh Added comment: Comment on list classification: It was decided in the NHSE GMS Cardiology Specialist Group meeting call on 25th January 2019 to promote this gene from Red to Amber on this panel.
Long QT syndrome v1.17 CALM1 Ellen McDonagh Gene: calm1 has been classified as Amber List (Moderate Evidence).
Long QT syndrome v1.16 CALM1 Ellen McDonagh Source South West GLH was added to CALM1.
Long QT syndrome v1.15 CALM1 Ellen McDonagh edited their review of gene: CALM1: Added comment: This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.; Changed rating: AMBER
Long QT syndrome v1.14 CALM1 Ellen McDonagh Source London South GLH was added to CALM1.
Long QT syndrome v1.10 CALM1 Oxford Medical Genetics Laboratory commented on gene: CALM1: Most pathogenic variants are detected in individuals with CPVT. Oxford cohort have de novo variants in CALM1 in individuals with a cross over phenotype LQT or VT.