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Hereditary neuropathy v1.353 ZFYVE26 Louise Daugherty Source Expert Review Green was added to ZFYVE26.
Rating Changed from Red List (low evidence) to Green List (high evidence)
Hereditary neuropathy v1.352 ZFYVE26 Louise Daugherty edited their review of gene: ZFYVE26: Added comment: The Neurology Specialist Test Group agreed that this gene was recommended for the WGS panel based on a broader phenotype view to include conditions where neuropathy is part of a more complex phenotype or where there is overlap with another neurological presentation eg. HSP. This panel includes conditions where neuropathy is part of a more complex phenotype or where there is overlap with another neurological presentation. This panel as going to be used for R78, but subsequently during the follow up call on 21st June with the Test Group it was agreed that it was more clinically relevant for R78 to be restricted to genes that are associated with isolated neuropathy and as a result a new panel was created https://panelapp.genomicsengland.co.uk/panels/846/ for this purpose.; Changed rating: GREEN
Hereditary neuropathy v1.300 ZFYVE26 Louise Daugherty commented on gene: ZFYVE26: Review and rating uploaded from file (Curation_Template_GMS_Neuro_AR_20190521.xlsx) submitted by Alex Rossor (UCL Institute of Neurology) on behalf of London North GLH for GMS Neurology specialist test group.
Hereditary neuropathy v1.120 ZFYVE26 Louise Daugherty Source London North GLH was added to ZFYVE26.
Hereditary neuropathy v1.105 ZFYVE26 Louise Daugherty Phenotypes for gene: ZFYVE26 were changed from Hereditary Neuropathies; Onset second decade, spastic paraplegia, intellectual disability and cognitive decline, thin corpus callosum, mild cerebellar eye signs, axonal sensory-motor neuropathy, parkinsonism and dystonia, pseudobulbar involvement and pigmentry maculopathy to Spastic paraplegia 15, autosomal recessive, 270700; Hereditary Neuropathies; Onset second decade, spastic paraplegia, intellectual disability and cognitive decline, thin corpus callosum, mild cerebellar eye signs, axonal sensory-motor neuropathy, parkinsonism and dystonia, pseudobulbar involvement and pigmentry maculopathy
Hereditary neuropathy v1.104 ZFYVE26 Louise Daugherty Phenotypes for gene: ZFYVE26 were changed from Hereditary Neuropathies to Hereditary Neuropathies; Onset second decade, spastic paraplegia, intellectual disability and cognitive decline, thin corpus callosum, mild cerebellar eye signs, axonal sensory-motor neuropathy, parkinsonism and dystonia, pseudobulbar involvement and pigmentry maculopathy
Hereditary neuropathy v1.103 ZFYVE26 Louise Daugherty Mode of inheritance for gene: ZFYVE26 was changed from to BIALLELIC, autosomal or pseudoautosomal
Hereditary neuropathy v1.81 ZFYVE26 Alexander Rossor edited their review of gene: ZFYVE26: Changed rating: GREEN; Changed phenotypes: Onset second decade, spastic paraplegia, intellectual disability and cognitive decline, thin corpus callosum, mild cerebellar eye signs, axonal sensory-motor neuropathy, parkinsonism and dystonia, pseudobulbar involvement and pigmentry maculopathy; Changed mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Hereditary neuropathy v1.81 ZFYVE26 Alexander Rossor Deleted their comment
Hereditary neuropathy v1.63 ZFYVE26 Louise Daugherty reviewed gene: ZFYVE26: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Hereditary neuropathy v1.60 ZFYVE26 Louise Daugherty Added phenotypes Hereditary Neuropathies for gene: ZFYVE26
Hereditary neuropathy v1.58 ZFYVE26 Natalie Forrester reviewed gene: ZFYVE26: Rating: RED; Mode of pathogenicity: ; Publications: ; Phenotypes: Hereditary Neuropathies; Mode of inheritance:
Hereditary neuropathy v1.57 ZFYVE26 Louise Daugherty Source NHS GMS was added to ZFYVE26.
Hereditary neuropathy v1.56 ZFYVE26 Louise Daugherty Source South West GLH was added to ZFYVE26.