AMER1

APC membrane recruitment protein 1
OMIM: 300647, Gene2Phenotype

6 panels

Panel Reviews Mode of inheritance Details
6 panels
Green AMER1 in Skeletal dysplasia


Level 2: Musculoskeletal
Version 8.46
Latest signed off version: v8.0 (30 Apr 2025)

Component of the following Super Panels:

  • Paediatric disorders
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • NHS GMS
    • Expert Review Green
    • Radboud University Medical Center, Nijmegen
    • Expert list
    • UKGTN
    Phenotypes
    • Osteopathia striata with cranial sclerosis 300373
    • Osteopathia striata with cranial sclerosis 300373
    Green AMER1 in Fetal anomalies


    Level 2: Fetal (including NIPD)
    Version 6.196
    Latest signed off version: v6.0 (30 Apr 2025)

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • PAGE DD-Gene2Phenotype
    Phenotypes
    • OSTEOPATHIA STRIATA WITH CRANIAL SCLEROSIS
    Green AMER1 in DDG2P


    Version 6.447
    Latest signed off version: v6.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • DD-Gene2Phenotype
    Phenotypes
    • OSTEOPATHIA STRIATA WITH CRANIAL SCLEROSIS 300373
    Green AMER1 in Clefting


    Level 2: Musculoskeletal
    Version 6.25
    Latest signed off version: v6.5 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Victorian Clinical Genetics Services
    • Expert Review Green
    Phenotypes
    • OSTEOPATHIA STRIATA WITH CRANIAL SCLEROSIS
    • OSCS
    • Cleft palate
    Green AMER1 in Intellectual disability


    Level 2: Developmental disorders
    Version 9.400
    Latest signed off version: v9.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    • BRIDGE study SPEED NEURO Tier1 Gene
    • BRIDGE study SPEED NEURO Tier1 Gene
    Phenotypes
    • Osteopathia striata with cranial sclerosis 300373
    Green AMER1 in Osteopetrosis


    Level 2: Musculoskeletal
    Version 1.38
    Latest signed off version: v1.1 (21 Sep 2020)

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • NHS GMS
    • Expert Review Green
    Phenotypes
    • Osteopathia striata with cranial sclerosis OMIM:300373