B2M

Red B2M in Periodic fever syndromes

Level 3: Multi-system inflammatory/autoimmune disorders
Level 2: Rheumatological disorders
Version 1.33

Sources

• Expert Review Red
• Radboud University Medical Center, Nijmegen
• Literature

Phenotypes

• ?Amyloidosis, familial visceral 105200

Green B2M in COVID-19 research

Level 2: Viral research
Version 1.141

Sources

• IUIS Classification February 2018
• London North GLH
• NHS GMS
• GRID V2.0
• North West GLH
• Victorian Clinical Genetics Services
• Expert Review Green
• NHS GMS
• North West GLH
• London North GLH
• IUIS Classification February 2018
• Victorian Clinical Genetics Services
• Expert Review Green
• GRID V2.0

Phenotypes

• Immunodeficiency 43,241600
• Immunodeficiency by defective expression of HLA class 1
• Sinopulmonary infections, cutaneous granulomas. Absent _2m associated proteins MHC-I, CD1a, CD1b, CD1c
• Immunodeficiencies affecting cellular and humoral immunity

Amber B2M in Hereditary systemic amyloidosis

Version 1.21
Latest signed off version: v1.18 (22 Mar 2023)

Component of the following Super Panels:

Sources

• Expert Review Amber
• NHS GMS

Phenotypes

• ?Amyloidosis, familial visceral 105200

Green B2M in Primary immunodeficiency or monogenic inflammatory bowel disease

Version 4.201
Latest signed off version: v4.0 (22 Mar 2023)

Sources

• Expert Review Green
• Other
• NHS GMS
• North West GLH
• London North GLH
• IUIS Classification February 2018
• Victorian Clinical Genetics Services
• GRID V2.0

Phenotypes

• Immunodeficiency 43,241600
• Immunodeficiency by defective expression of HLA class 1
• Sinopulmonary infections, cutaneous granulomas. Absent _2m associated proteins MHC-I, CD1a, CD1b, CD1c
• Immunodeficiencies affecting cellular and humoral immunity

Green B2M in Severe Paediatric Disorders

Version 1.184

Sources

• Next Generation Children Project
• Expert Review Green
• Expert list

Phenotypes

• ?Amyloidosis, familial visceral
• Immunodeficiency 43, 241600