CACNA1D

calcium voltage-gated channel subunit alpha1 D
OMIM: 114206, Gene2Phenotype

6 panels

Panel Reviews Mode of inheritance Details
6 panels
Green CACNA1D in Congenital hyperinsulinism


Level 2: Endocrinology
Version 3.7
Latest signed off version: v3.0 (22 Mar 2023)

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • NHS GMS
Phenotypes
  • hyperinsulinaemic hypoglycaemia, heart defects
  • severe hypotonia
Amber CACNA1D in Fetal anomalies


Level 2: Fetal (including NIPD)
Version 6.140
Latest signed off version: v6.0 (30 Apr 2025)

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Amber
  • PAGE DD-Gene2Phenotype
Phenotypes
  • Primary aldosteronism, seizures, and neurologic abnormalities, OMIM:615474
Green CACNA1D in DDG2P


Version 6.424
Latest signed off version: v6.0 (30 Apr 2025)

Component of the following Super Panels:

  • Paediatric disorders
  • review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • DD-Gene2Phenotype
    Phenotypes
    • PRIMARY ALDOSTERONISM, SEIZURES, AND NEUROLOGIC ABNORMALITIES 615474
    • SINOATRIAL NODE DYSFUNCTION AND DEAFNESS 614896
    Red CACNA1D in Monogenic hearing loss


    Level 2: Audiology
    Version 5.57
    Latest signed off version: v5.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • review Not set
    Sources
    • Expert
    • Radboud University Medical Center, Nijmegen
    Phenotypes
    • Sinoatrial node dysfunction and deafness, 614896
    Green CACNA1D in Early onset or syndromic epilepsy


    Level 2: Neurology
    Version 8.125
    Latest signed off version: v8.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • Unexplained death in infancy and sudden unexplained death in childhood
  • review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Wessex and West Midlands GLH
    • NHS GMS
    • Literature
    • Literature
    Phenotypes
    • Primary aldosteronism, seizures, and neurologic abnormalities 615474 AD
    • Sinoatrial node dysfunction and deafness 614896 AR
    Green CACNA1D in Intellectual disability


    Level 2: Developmental disorders
    Version 9.285
    Latest signed off version: v9.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders
  • review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert Review Green
    Phenotypes
    • Primary aldosteronism, seizures, and neurologic abnormalities 615474 AD
    • Sinoatrial node dysfunction and deafness 614896 AR